cognitive impairment

Does efavirenz replacement improve neurological function in treated HIV infection?

Authors: B Payne, T J Chadwick, A Blamire, K N Anderson, J Parikh, J Qian, A M Hynes, J Wilkinson, D A Price, Efficacy of Switch to Lopinavir/Ritonavir in Improving Cognitive Function in Efavirenz-treated Patients (SLICE) study team

Journal: HIV Medicine

Year Published: 2017

Objectives: The contribution of specific antiretroviral drugs to cognitive function in HIV-infected people remains poorly understood. Efavirenz (EFV) may plausibly cause cognitive impairment. The objective of this study was therefore to determine whether chronic EFV therapy […]

Associations between cognitive impairment and patient-reported measures of physical/mental functioning in older people living with HIV

Authors: J Underwood, D De Francesco, F A Post, J H Vera, I Williams, M Boffito, P W Mallon, J Anderson, M Sachikonye, C Sabin, A Winston, Pharmacokinetic and Clinical Observations in People Over Fifty (POPPY) study group

Journal: HIV Medicine

Year Published: 2016

Objectives: While cognitive impairment is frequently reported in HIV-positive individuals and has historically been associated with poorer functional outcomes, the associations between cognitive impairment and patient-reported outcome measures (PROMs) in contemporary cohorts are unclear. Methods: We […]

Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer’s Disease

Authors: Annie M Racine, Lindsay R Clark, Sara E Berman, Rebecca L Koscik, Kimberly D Mueller, Derek Norton, Christopher R Nicholas, Kaj Blennow, Henrik Zetterberg, Bruno Jedynak, Murat Bilgel, Cynthia M Carlsson, Bradley T Christian, Sanjay Asthana, Sterling C Johnson

Journal: Journal of Alzheimer's Disease

Year Published: 2016

It is not known whether computerized cognitive assessments, like the CogState battery, are sensitive to preclinical cognitive changes or pathology in people at risk for Alzheimer’s disease(AD). In 469 late middle-aged participants from the Wisconsin Registry […]

Neuropsychological Impairment and Its Association with Violence Risk in Japanese Forensic Psychiatric Patients: A Case-Control Study

Authors: Hirofumi Nishinaka, Jun Nakane, Takako Nagata, Atsushi Imai, Noriomi Kuroki, Noriko Sakikawa, Mayu Omori, Osamu Kuroda, Naotsugu Hirabayashi, Yoshito Igarashi, Kenji Hashimoto

Journal: Public Library of Science One

Year Published: 2016

Background: In Japan, the legislation directing treatment of offenders with psychiatric disorders was enacted in 2005. Neuropsychological impairment is highly related to functional outcomes in patients with psychiatric disorders, and several studies have suggested an association […]

A randomized controlled trial of light versus deep propofol sedation for elective outpatient colonoscopy: recall, procedural conditions, and recovery

Authors: Megan Allen, Kate Leslie, Geoffrey Hebbard, Ian Jones, Tejinder Mettho, Paul Maruff

Journal: Canadian Journal of Anaesthesia

Year Published: 2015

Purpose: This study aimed to determine if the incidence of recall was equivalent between light and deep sedation for colonoscopy. Secondary analysis included complications, patient clinical recovery, and post-procedure cognitive impairment. Methods: Two hundred patients undergoing […]

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