White matter correlates of slowed information processing speed in unimpaired multiple sclerosis patients with young age onset
Slowed information processing speed is among the earliest markers of cognitive impairment in multiple sclerosis (MS) and has been associated with white matter (WM) structural integrity. Localization of WM tracts associated with slowing, but not significant […]
Relation between retinal vascular abnormalities and working memory impairment in patients with schizophrenia and bipolar disorder
Emerging evidence indicates abnormal retinal micro-vasculature in schizophrenia (SCZ) and bipolar disorder (BD) and its relation to cognitive functions. However, the association of these abnormalities with the cognitive deficits in these disorders has not been examined till date.
Protocol for a prospective cohort study of assessing postoperative cognitive changes after total hip and knee arthroplasty in the Greater Toronto area
Introduction: Cognitive changes after anaesthesia and surgery, such as delirium and postoperative cognitive dysfunction (POCD), are common and lead to poor outcomes and increased healthcare costs. While several interventions for delirium exist, there are no effective […]
Comparing cognitive clusters across first- and multiple-episode of psychosis
Cognitive impairments in psychotic disorders (PD) present heterogeneously across patients. Between 2 and 5 clusters have been identified in previous studies with first-episode (FEP) and multiple-episodes of psychosis (MEP) patients suggesting different profiles of impairment. Past […]
Perioperative Research into Memory (PRiMe): Cognitive impairment following a severe burn injury and critical care admission, part 1
Introduction: An investigation into long-term cognitive impairment and Quality of Life (QoL) after severe burns. Methods: A proof of principle, cohort design, prospective, observational clinical study. Patients with severe burns (>15% TBSA) admitted to Burns ICU […]
