Access hundreds of peer-reviewed papers published by neuroscientists using Cogstate technology.

Cognitive Profile and Relationship with Quality of Life and Psychosocial Functioning in Mood Disorders

Authors: Robson Zazula, Mohammadreza Mohebbi, Seetal Dodd, Olivia M Dean, Michael Berk, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes

Journal: Archives of Clinical Neuropsychology

Year Published: 2022

Background: Comparisons between healthy controls (HCs) and individuals with mood disorders have shown more cognitive dysfunction among the latter group, in particular in bipolar disorder (BD). This study aimed to characterize the pattern of cognitive function […]

A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M 1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer’s disease

Authors: Pradeep J Nathan, S Babli Millais, Alex Godwood, Odile Dewit, David M Cross, Janet Liptrot, Bharat Ruparelia, Stephen Paul Jones, Geor Bakker, Paul T Maruff, Gregory A Light, Alastair J H Brown, Malcolm Peter Weir, Miles Congreve, Tim Tasker

Journal: Alzheimer's & Dementia

Year Published: 2022

Introduction: This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild-to-moderate Alzheimer’s disease (AD) on background donepezil 10 mg/day. Methods: A randomized, double-blind, placebo-controlled 4-week […]

Severe childhood trauma and emotion recognition in males and females with first-episode psychosis

Authors: Danielle Penney, Marita Pruessner, Ashok K Malla, Ridha Joober, Martin Lepage

Journal: Early Intervention in Psychiatry

Year Published: 2022

Aim: Childhood trauma increases social functioning deficits in first-episode psychosis (FEP) and is negatively associated with higher-order social cognitive processes such as emotion recognition (ER). We investigated the relationship between childhood trauma severity and ER capacity, […]

Neurocognitive effects of repeated ketamine infusions in comorbid posttraumatic stress disorder and major depressive disorder

Authors: C Sophia Albott, Kelvin O Lim, Christopher Erbes, Paul Thuras, Joseph Wels, Susanna J Tye, Paulo R Shiroma

Journal: Journal of Affective Disorders

Year Published: 2022

Background: The glutamate N-methyl-d-aspartate (NMDA) receptor antagonist ketamine rapidly ameliorates posttraumatic stress disorder (PTSD) and depression symptoms in individuals with comorbid PTSD and major depressive disorder (MDD). However, concerns over ketamine’s potential neurocognitive side effects have […]

EEG asymmetry and cognitive testing in MCI identification

Authors: Tim Martin, Bruno Giordani, Voyko Kavcic

Journal: International Journal of Psychophysiology

Year Published: 2022

Background: Finding the baseline resting-state EEG markers for early identification of cognitive decline can contribute to the identification of individuals at risk of further change. Potential applications include identifying participants for clinical trials, early treatment, and […]

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