cognitive impairment

Clinical trials of potential cognitive-enhancing drugs in schizophrenia: what have we learned so far?

Authors: Richard S E Keefe, Robert W Buchanan, Stephen R Marder, Nina R Schooler, Ashish Dugar, Milana Zivkov, Michelle Stewart

Journal: Schizophrenia Bulletin

Year Published: 2013

In light of the number of studies conducted to examine the treatment of cognitive impairment associated with schizophrenia (CIAS), we critically reviewed recent CIAS trials. Trials were identified through searches of the website “www.clinicaltrials.gov” using the […]

Computerized cognitive remediation training for schizophrenia: an open label, multi-site, multinational methodology study

Authors: N V Murthy, H Mahncke, B E Wexler, P Maruff, A Inamdar, M Zucchetto, J Lund, S Shabbir, S Shergill, M Keshavan, S Kapur, M Laruelle, R Alexander

Journal: Schizophrenia Research

Year Published: 2012

A recent single-site study (Fisher et al., 2009. Am J Psychiatry. 166 (7) 805-11) showed that repeated training with the Brain Fitness Program (BFP) improved performance on a battery of neuropsychological tasks. If replicated these data […]

Cutting a long story short: reaction times in acute stroke are associated with longer term cognitive outcomes

Authors: Toby B Cumming, Amy Brodtmann, David Darby, Julie Bernhardt

Journal: Journal of the Neurological Sciences

Year Published: 2012

Background: The viability and usefulness of cognitive assessment in acute stroke have been questioned, with practical challenges arising from the focal nature of neurological deficits as well as heterogeneity in arousal state. We aimed to test […]

Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder

Authors: Taisuke Yoshida, Masatomo Ishikawa, Tomihisa Niitsu, Michiko Nakazato, Hiroyuki Watanabe, Tetsuya Shiraishi, Akihiro Shiina, Tasuku Hashimoto, Nobuhisa Kanahara, Tadashi Hasegawa, Masayo Enohara, Atsushi Kimura, Masaomi Iyo, Kenji Hashimoto

Journal: Public Library of Science One

Year Published: 2012

Background: Meta-analyses have identified serum levels of brain-derived neurotrophic factor (BDNF) as a potential biomarker for major depressive disorder (MDD). However, at the time, commercially available human ELISA kits are unable to distinguish between proBDNF (precursor […]

Reliability and validity of the CogState battery Chinese language version in schizophrenia

Authors: Na Zhong, Haifeng Jiang, Jin Wu, Hong Chen, Shuxing Lin, Yan Zhao, Jiang Du, Xiancang Ma, Ce Chen, Chengge Gao, Kenji Hashimoto, Min Zhao

Journal: Public Library of Science One

Year Published: 2013

Background: Cognitive impairment in patients with schizophrenia is a core symptom of this disease. The computerized CogState Battery (CSB) has been used to detect seven of the most common cognitive domains in schizophrenia. The aim of […]

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