Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months.
High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. However, the relationship between these two biomarkers and […]
Designing and Evaluating Brain Powered Games for Cognitive Training and Rehabilitation in At-Risk African Children
Background: Valid, reliable, accessible, and cost-effective computer-training approaches can be important components in scaling up educational support across resource-poor settings, such as sub-Saharan Africa. The goal of the current study was to develop a computer-based training […]
A pilot study of the neuropsychological benefits of computerized cognitive rehabilitation in Ugandan children with HIV
Objective: Because antiretroviral treatment (ART) fails to improve neurocognitive impairment in children with HIV, we completed a pilot study evaluating the feasibility and cognitive benefit of computerized cognitive rehabilitation therapy (CCRT) in Ugandan children with HIV. […]
Transdermal testosterone improves verbal learning and memory in postmenopausal women not on oestrogen therapy
Objective: The aim of this study was to examine the effects of testosterone on verbal learning and memory in postmenopausal women. Design: Randomized, placebo-controlled trial in which participants were randomized (1:1) to transdermal testosterone gel 300 mcg/day, […]
Cognitive impairment in Aboriginal people with heavy episodic patterns of alcohol use
Background: With chronic alcohol abuse, cognitive studies suggest that progressive cognitive decline may precede more serious and irreversible neurological syndromes. The early detection of cognitive impairment may therefore aid in the prevention of permanent brain damage. […]