alzheimer's disease

Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-β: prodromal Alzheimer’s disease?

Authors: Yen Ying Lim, Kathryn A Ellis, Karra Harrington, Robert H Pietrzak, Joanne Gale, David Ames, Ashley I Bush, David Darby, Ralph N Martins, Colin L Masters, Christopher C Rowe, Greg Savage, Cassandra Szoeke, Victor L Villemagne, Paul Maruff

Journal: Journal of Alzheimer's Disease

Year Published: 2013

We aimed to characterize the nature and magnitude of cognitive decline in a group of adults with amnestic mild cognitive impairment (aMCI) with high and low levels of amyloid-β (Aβ) in relation to healthy older adults […]

Three-month stability of the CogState brief battery in healthy older adults, mild cognitive impairment, and Alzheimer’s disease: results from the Australian Imaging, Biomarkers, and Lifestyle-rate of change substudy (AIBL-ROCS)

Authors: Yen Ying Lim, Judith Jaeger, Karra Harrington, Tim Ashwood, Kathryn A Ellis, Albrecht Stöffler, Cassandra Szoeke, Rebecca Lachovitzki, Ralph N Martins, Victor L Villemagne, Ashley Bush, Colin L Masters, Christopher C Rowe, David Ames, David Darby, Paul Maruff

Journal: Archives of Clinical Neuropsychology

Year Published: 2013

Large prospective studies of Alzheimer’s disease (AD) have sought to understand the pathological evolution of AD and factors that may influence the rate of disease progression. Estimates of rates of cognitive change are available for 12 […]

A randomized, double-blind, placebo-controlled, 16-week study of the H3 receptor antagonist, GSK239512 as a monotherapy in subjects with mild-to-moderate Alzheimer’s disease

Authors: Richard A Grove, Conn M Harrington, Andreas Mahler, Isabel Beresford, Paul Maruff, Martin T Lowy, Andrew P Nicholls, Rebecca L Boardley, Alienor C Berges, Pradeep J Nathan, Joseph P Horrigan

Journal: Current Alzheimer Research

Year Published: 2014

Introduction: Histaminergic H3 receptors may play a role in modulating cholinergic and monoaminergic neurotransmission. This Phase II study evaluated the efficacy and safety of GSK239512, a highly potent, brain penetrant H3 receptor antagonist as monotherapy treatment […]

Computerized Neurocognitive Test (CNT) in Mild Cognitive Impairment and Alzheimer’s Disease

Authors: Maira Okada de Oliveira, Sonia Maria Dozzi Brucki

Journal: Dementia & Neuropsychologia

Year Published: 2014

Currently, computerized batteries are of great value in detecting cognitive impairment. This aim of this review was to compare the computerized neurocognitive batteries used in most studies with cognitive decline over the last 10 years. Using […]

Clinical Utility of the Cogstate Brief Battery in Identifying Cognitive Impairment in Mild Cognitive Impairment and Alzheimer’s Disease

Authors: Paul Maruff, Yen Ying Lim, David Darby, Kathryn A Ellis, Robert H Pietrzak, Peter J Snyder, Ashley I Bush, Cassandra Szoeke, Adrian Schembri, David Ames, Colin L Masters, AIBL Research Group

Journal: BMC Psychology

Year Published: 2013

Background: Previous studies have demonstrated the utility and sensitivity of the CogState Brief Battery (CBB) in detecting cognitive impairment in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) and in assessing cognitive changes in the preclinical […]

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