Association between anxiety, stress, and cognition in middle-aged adults at risk for Alzheimer’s disease: Results from the Healthy Brain Project
Background: Anxiety and stress have been identified as potential risk factors of cognitive impairment, but research examining this association in midlife has been limited. Methods: The current study examined associations between anxiety and stress symptoms, and […]
Can vigorous physical activity mitigate the effect of systemic inflammation on cognitive performance? Results from a large older community dwelling population in The Netherlands
Background: Elevated systemic inflammation is associated with poorer cognitive function, while vigorous physical activity enhances cognition. Objective: This study examines whether physical activity moderates the relationship between systemic inflammation and cognitive performance. Methods: We analyzed 24,661 […]
Cognitive performance and blood biomarkers: Insights into their relationship and predicting high Amyloid Probability Score in cognitively impaired older adults
Background: Understanding associations between cognitive performance and blood biomarkers supports diagnosis and treatment of Alzheimer’s disease (AD); however, this relationship remains unclear. Objective: Exploring associations between the Amyloid Probability Score (APS; PrecivityAD® blood test) and cognitive […]
Application of the Cogstate Brief Battery in assessing cognitive function in older Japanese individuals
Background: Accurate and simple detection of cognitive decline is important for the prediction of dementia and identification of drug indications. The Cogstate Brief Battery (CBB) is useful in assessing cognitive function during the preclinical and mild […]
Clearance and transport of amyloid β by peripheral monocytes correlate with Alzheimer’s disease progression
Impaired clearance of amyloid β (Aβ) in late-onset Alzheimer’s disease (AD) affects disease progression. The role of peripheral monocytes in Aβ clearance from the central nervous system (CNS) is unclear. We use a flow cytometry assay […]
