Neurocognitive effects of repeated ketamine infusions in comorbid posttraumatic stress disorder and major depressive disorder
Background: The glutamate N-methyl-d-aspartate (NMDA) receptor antagonist ketamine rapidly ameliorates posttraumatic stress disorder (PTSD) and depression symptoms in individuals with comorbid PTSD and major depressive disorder (MDD). However, concerns over ketamine’s potential neurocognitive side effects have […]
The association of posttraumatic stress disorder, depression, and head injury with mid-life cognitive function in civilian women
Background: Despite evidence linking posttraumatic stress disorder (PTSD), depression, and head injury, separately, with worse cognitive performance, investigations of their combined effects on cognition are limited in civilian women. Methods: The Cogstate Brief Battery assessment was […]
Neuroinflammation in World Trade Center responders at midlife: A pilot study using [ 18 F]-FEPPA PET imaging
Background: Neuroinflammation has long been theorized to arise from exposures to fine particulate matter and to be modulated when individuals experience chronic stress, both of which are also though to cause cognitive decline in part as […]
Traumatic exposures, posttraumatic stress disorder, and cognitive functioning in World Trade Center responders
Introduction: This study examined whether World Trade Center (WTC)-related exposures and posttraumatic stress disorder (PTSD) were associated with cognitive function and whether WTC responders’ cognition differed from normative data. Methods: A computer-assisted neuropsychological battery was administered […]
Posttraumatic stress disorder symptoms and cognitive function in a large cohort of middle-aged women
Background: Posttraumatic stress disorder (PTSD) has been linked to cognitive decline, but research in women is generally lacking. We examined whether trauma and elevated PTSD symptoms were associated with worse cognitive function in middle-aged civilian women. […]
