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18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.

Authors: Berger M, Bisanar T, Borges-Neto S, Doraiswamy PM, James OG, Klinger RY, Li YJ, Mathew JP, Newman MF, Qi W, Terrando N

Journal: Anesthesiology

DOI: 10.1097/ALN.0000000000002103.

Year Published: 2018

BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and […]

Indication of Cognitive Change and Associated Risk Factor after Thoracic Surgery in the Elderly: A Pilot Study.

Authors: Hoshikawa Y, Kawashima R, Kulason K, Noda M, Nouchi R, Okada Y

Journal: Frontiers in Aging Neuroscience

Volume & Issue: 9

Page No.: 396

DOI: 10.3389/fnagi.2017.00396

Year Published: 2018

Background: This pilot study investigated the effects of partial pulmonary lobectomy lung surgery on cognitive functions of elderly Japanese patients. It is recognized that elderly patients undergoing surgery have increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly patients are more […]

Neuronal damage biomarkers in the identification of patients at risk of long-term postoperative cognitive dysfunction after cardiac surgery.

Authors: Absalom AR, Koerts J, Kok WF, Scheeren TW, Tucha O

Journal: Anaesthesia

Volume & Issue: 72 & 3

Page No.: 359-369

Year Published: 2017

Biomarkers of neurological injury can potentially predict postoperative cognitive dysfunction. We aimed to identify whether classical neuronal damage-specific biomarkers, including brain fatty acid-binding protein, neuron-specific enolase and S100 calcium-binding protein β, as well as plasma-free haemoglobin concentration as a measure of haemolysis, could be used to predict the risk of long-term cognitive decline after coronary […]

The beneficial effects of cognitive training with simple calculation and reading aloud in an elderly postsurgical population: study protocol for a randomized controlled trial.

Authors: Hoshikawa Y, Kawashima R, Kulason K, Noda M, Nouchi R, Okada Y

Journal: Trials Journal

Volume & Issue: 17

Page No.: 334

DOI: 10.1186/s13063-016-1476-0

Year Published: 2016

BACKGROUND: This project proposes a pilot study to investigate the positive healing effects of cognitive training with simple arithmetic and reading aloud on elderly postsurgical patients. Elderly patients undergoing surgery have an increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly […]

Prevalence of Dementia 7.5 Years after Coronary Artery Bypass Graft Surgery.

Authors: Ames D, Evered LA, Maruff P, Scott DA, Silbert BS

Journal: Anesthesiology

Volume & Issue: 125

Page No.: 62-71

DOI: 10.1097/ALN.0000000000001143

Year Published: 2016

BACKGROUND: Although postoperative cognitive dysfunction (POCD) is well described after coronary artery bypass graft (CABG) surgery, a major concern has been that a progressive decline in cognition will ultimately lead to dementia. Since dementia interferes with the ability to carry out daily functions, the impact has far greater ramifications than cognitive decline defined purely by […]

Statistical and conceptual issues in defining post-operative cognitive dysfunction.

Authors: Lewis M, Maruff P, Silbert B

Journal: Neuroscience and Biobehavioral Reviews

Volume & Issue: 28 & 4

Page No.: 433-40

DOI: 10.1016/j.neubiorev.2004.05.002

Year Published: 2004

The occurrence of post-operative cognitive dysfunction is a distressing complication following surgery. In an effort to gain a more complete understanding of patients’ cognitive recovery following surgical procedures common neuropsychological assessment tools have been adopted in a repeated measures design. It is widely regarded that this represents the most comprehensive method of determining cognitive status […]