Orexin-A

Higher orexin-A levels are associated with treatment response to clozapine in patients with schizophrenia: A cross-sectional study

Authors: Po-Yu Chen, Chih-Chiang Chiu, Chin-Kuo Chang, Mong-Liang Lu, Cho-Yin Huang, Chun-Hsin Chen, Ming-Chyi Huang

Journal: Journal of Psychopharmacology

Year Published: 2024

Background: Clozapine is the primary antipsychotic (APD) for treatment-resistant schizophrenia (TRS). However, only 40% of patients with TRS respond to clozapine, constituting a subgroup of clozapine-resistant patients. Recently, the neuropeptide orexin-A was shown to be involved […]

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