A randomized controlled trial for measuring effects on cognitive functions of adding ketamine to propofol during sedation for colonoscopy

Authors: Liang Tian, Hengfei Luan, Pin Zhu, Zhiyuan Zhang, Hongguang Bao

Journal: Medicine

Year Published: 2020

Background: The purpose of this study was to evaluate the effects of adding ketamine to propofol on cognitive functions in patients undergoing sedation for colonoscopy. Methods: In this randomized, double-blinded, and controlled study, 200 patients were […]

Attenuation of ketamine-induced impairment in verbal learning and memory in healthy volunteers by the AMPA receptor potentiator PF-04958242

Authors: M Ranganathan, N DeMartinis, B Huguenel, F Gaudreault, M M Bednar, C L Shaffer, S Gupta, J Cahill, M A Sherif, J Mancuso, L Zumpano, D C D'Souza

Journal: Molecular Psychiatry

Year Published: 2017

There is a need to develop treatments for cognitive impairment associated with schizophrenia (CIAS). The significant role played by N-methyl-d-aspartate receptors (NMDARs) in both the pathophysiology of schizophrenia and in neuronal plasticity suggests that facilitation of […]

Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression

Authors: Paulo R Shiroma, C Sophia Albott, Brian Johns, Paul Thuras, Joseph Wels, Kelvin O Lim

Journal: The International Journal of Neuropsychopharmacology

Year Published: 2014

The N-methyl-D-aspartate glutamate receptor antagonist ketamine has demonstrated rapid antidepressant effects in treatment-resistant depression (TRD). However, evaluation of ketamine’s neurocognitive aspects in TRD has started to be explored. This study aims to (1) examine baseline neurocognitive […]

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