A randomized controlled trial for measuring effects on cognitive functions of adding ketamine to propofol during sedation for colonoscopy
Background: The purpose of this study was to evaluate the effects of adding ketamine to propofol on cognitive functions in patients undergoing sedation for colonoscopy. Methods: In this randomized, double-blinded, and controlled study, 200 patients were […]
Attenuation of ketamine-induced impairment in verbal learning and memory in healthy volunteers by the AMPA receptor potentiator PF-04958242
There is a need to develop treatments for cognitive impairment associated with schizophrenia (CIAS). The significant role played by N-methyl-d-aspartate receptors (NMDARs) in both the pathophysiology of schizophrenia and in neuronal plasticity suggests that facilitation of […]
Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression
The N-methyl-D-aspartate glutamate receptor antagonist ketamine has demonstrated rapid antidepressant effects in treatment-resistant depression (TRD). However, evaluation of ketamine’s neurocognitive aspects in TRD has started to be explored. This study aims to (1) examine baseline neurocognitive […]
