Effect of hyperbilirubinaemia on neurocognitive, renal, bone and cardiovascular markers in HIV infection treated with boosted protease inhibitors
Introduction: Use of some protease inhibitors (PI) is associated with unconjugated hyperbilirubinaemia (HBR), due to inhibition of UGT1A1. As observed in Gilbert’s syndrome, HBR may have antioxidant and anti-inflammatory effects. Inflammation may be relevant to neurocognitive […]
Does acute hepatitis C infection affect the central nervous system in HIV-1 infected individuals?
Central nervous system (CNS) manifestations of chronic hepatitis C virus (HCV) and chronic human immune deficiency virus-1 (HIV-1) infections have been reported, but the impact of acute HCV infection on the CNS is unknown. A total […]
Cerebral function tests reveal differences in HIV-infected subjects with and without chronic HCV co-infection
Neurocognitive impairment (NCI) remains prevalent in HIV-infected subjects despite effective combination antiretroviral therapy (CART). In subjects without evidence of hepatic decompensation, NCI is also a feature of chronic HCV infection. The present study aimed to examine […]
