HIV

Correlation between computerised and standard cognitive testing in people with HIV and HIV-negative individuals

Authors: Davide De Francesco, Jonathan Underwood, Jane Anderson, Marta Boffito, Frank A Post, Memory Sachikonye, Patrick W G Mallon, Lewis Haddow, Jaime H Vera, Ken M Kunisaki, Caroline A Sabin, Alan Winston for the POPPY Study Group

Journal: AIDS Care

Year Published: 2020

We investigated the correlations and agreement between cognitive assessments made using a computerised (CogState™, six domains) and a standard pen-and-paper battery (five domains) in PWH and lifestyle-similar HIV-negative individuals. Demographically adjusted domain and global T-scores were […]

Cognitive ageing is premature among a community sample of optimally treated people living with HIV

Authors: H L Aung, M Bloch, T Vincent, D Quan, A Jayewardene, Z Liu, T M Gates, B Brew, L Mao, L A Cysique

Journal: HIV Medicine

Year Published: 2020

Objectives: Evidence of premature cognitive ageing amongst people living with HIV (PLHIV) remains controversial due to previous research limitations including underpowered studies, samples with suboptimal antiretroviral access, varying rate of virological control, high rate of AIDS, […]

Changes in functional connectivity in people with HIV switching antiretroviral therapy

Authors: Sofia Toniolo, Mara Cercignani, Borja Mora-Peris, Jonathan Underwood, Jasmini Alagaratnam, Marco Bozzali, Marta Boffito, Mark Nelson, Alan Winston, Jaime H Vera

Journal: Journal of Neuro Virology

Year Published: 2020

We assessed changes in functional connectivity by fMRI (functional magnetic resonance imaging) and cognitive measures in otherwise neurologically asymptomatic people with HIV (PWH) switching combination antiretroviral therapy (cART). In a prospective study (baseline and follow-up after […]

Depression, lifestyle factors and cognitive function in people living with HIV and comparable HIV-negative controls

Authors: D De Francesco, J Underwood, E Bagkeris, M Boffito, FA Post, PWG Mallon, JH Vera, I Williams, J Anderson, M Johnson, CA Sabin, A Winston, on behalf of the Pharmacokinetic and Clinical Observations in People over Fifty (POPPY) study

Journal: HIV Medicine

Year Published: 2019

Objectives: We investigated whether differences in cognitive performance between people living with HIV (PLWH) and comparable HIV-negative people were mediated or moderated by depressive symptoms and lifestyle factors. Methods: A cross-sectional study of 637 ‘older’ PLWH […]

Similar neurocognitive outcomes after 48 weeks in HIV-1-infected participants randomized to continue tenofovir/emtricitabine + atazanavir/ritonavir or simplify to abacavir/lamivudine + atazanavir

Authors: Kevin Robertson, Paul Maruff, Lisa L. Ross, David Wohl, Catherine B Small, Howard Edelstein & Mark S. Shaefer

Journal: Journal of Neurovirology

Year Published: 2019

Human immunodeficiency virus (HIV)-associated neurocognitive disorders can persist in many patients despite achieving viral suppression while on antiretroviral therapy (ART). Neurocognitive function over 48 weeks was evaluated using a Cogstate test battery assessing psychomotor function, attention, […]

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Cogstate acknowledges Aboriginal and Torres Strait Islander people as the Traditional Custodians of the lands where many of our team members live and work. We pay respect to their Elders past and present.