Exploring the repurposing potential of β2-adrenergic receptor agonists for cognitive function: Evidence from the PharmLines Initiative Retrospective Cohort Study
Background: Preclinical studies suggest β2-adrenergic receptor agonists may exert neuroprotective effects, but evidence in human populations is limited. Objective: To examine the association between β2-adrenergic receptor agonist use and cognitive performance in older adults. Methods: This […]
Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults
Introduction: Obstructive sleep apnea (OSA) is a potential risk factor for cognitive impairment and dementia; however, its contribution in midlife and interactions with APOE ε4 remain unclear. Methods: Participants were 2795 cognitively unimpaired, middle-aged adults enrolled […]
Remote, unsupervised assessment of cognitive impairment and decline in Alzheimer’s disease using the Cogstate Brief Battery in ADNI-3
Introduction: Remote neuropsychological testing can monitor brain health in individuals with or at risk of Alzheimer’s disease (AD). We evaluated acceptability and validity of the Cogstate Brief Battery (CBB) for remote administration. Methods: Non-demented adults from […]
Cognitive, Electrophysiological, and Behavioral Presentation of First-Episode Psychosis With or Without Cannabis Exposure
Objective: Cannabis use is a known risk factor for psychosis, but it remains unclear whether cannabis-associated psychosis (CAP) differs meaningfully from non-cannabis-associated psychosis (NCAP) in clinical presentation, biology, or illness course. The objective of this study […]
Ultra-processed food intake, cognitive function, and dementia risk: A cross-sectional study of middle-aged and older Australian adults
Introduction: Ultra-processed food (UPF) consumption is linked to over 30 adverse health outcomes, including several risk factors for dementia such as cardiovascular disease, type 2 diabetes, and obesity. We aimed to examine the association of UPF […]
