alzheimer’s disease

Cognitive Go/No-Go decision-making criteria in Alzheimer’s disease drug development

Authors: Alette M. Wessels, Chris J. Edgar, Pradeep J. Nathan, Eric R. Siemers, Paul Maruff, John Harrison

Journal: Drug Discovery Today

Year Published: 2021

Go/No-Go decision making in early phase clinical trials is challenging for drug developers working in Alzheimer’s disease. Recent negative trial results have been attributed to a lack of efficacy and important safety concerns. Furthermore, demonstrated target […]

Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia

Authors: Yen Ying Lim, Victor L Villemagne, Simon M Laws, Robert H Pietrzak, David Ames, Christopher Fowler, Stephanie Rainey-Smith, Peter J Snyder, Pierrick Bourgeat, Ralph N Martins, Olivier Salvado, Christopher C Rowe, Colin L Masters, Paul Maruff, AIBL Research Group

Journal: Journal of Molecular Neuroscience

Year Published: 2016

In a group of older adults with very mild dementia, we aimed to characterize the nature and magnitude of cognitive decline as measured by the Cogstate Brief Battery, in relation to Aβ levels and hippocampal volume. […]

Methodological Aspects of the Phase II Study AFF006 Evaluating Amyloid-beta -Targeting Vaccine AFFITOPE® AD02 in Early Alzheimer’s Disease – Prospective Use of Novel Composite Scales

Authors: S Hendrix, N Ellison, S Stanworth, L Tierney, F Mattner, W Schmidt, B Dubois, A Schneeberger

Journal: The Journal of Prevention of Alzheimer's Disease

Year Published: 2016

Background: Optimized scales and composite outcomes have been proposed as a way to more accurately measure Alzheimer’s disease related decline. AFFITOPE® AD02, is an amyloid-beta (Aβ)-targeting vaccine to elicit anti-Aβ antibodies. IMM-AD04, commonly known as Alum, […]

Detection of MCI in the clinic: Evaluation of the sensitivity and specificity of a computerised test battery, the Hopkins Verbal Learning Test and the MMSE

Authors: Celeste A de Jager, Anne-Claire M C Schrijnemaekers, Thurza E M Honey, Marc M Budge

Journal: Age and Ageing

Year Published: 2009

Introduction: The sensitive detection of mild cognitive impairment (MCI) in older adults is an important problem that requires objective assessment. We evaluated whether the computerised cognitive test battery, CogState, was as sensitive to MCI as two […]

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