alzheimer’s disease

Visual Memory Deficits in Middle-Aged APOEɛ4 Homozygotes Detected Using Unsupervised Cognitive Assessments

Authors: Yen Ying Lim, Matthew P Pase, Rachel F Buckley, Nawaf Yassi, Lisa Bransby, Christopher Fowler, Simon M Laws, Colin L Masters, Paul Maruff

Journal: Journal of Alzheimer's Disease

Year Published: 2021

Background: The apolipoprotein E (APOE) ɛ4 allele is associated with dose-response effects on cognitive dysfunction and dementia risk in older adults. However, its effects on cognition in middle-aged adults remains unclear. Objective: We examined effects of […]

The Trial-Ready Cohort for Preclinical and Prodromal Alzheimer’s Disease (TRC-PAD): Experience from the First 3 Years

Authors: S Walter, O G Langford, T B Clanton, G A Jimenez-Maggiora, R Raman, M S Rafii, E J Shaffer, R A Sperling, J L Cummings, P S Aisen

Journal: The Journal of Prevention of Alzheimer's Disease

Year Published: 2020

Background: The Trial-Ready Cohort for Preclinical and Prodromal Alzheimer’s disease (TRC-PAD) aims to accelerate enrollment for Alzheimer’s disease (AD) clinical trials by remotely identifying and tracking individuals who are at high risk for developing symptoms of […]

Cognitive Go/No-Go decision-making criteria in Alzheimer’s disease drug development

Authors: Alette M. Wessels, Chris J. Edgar, Pradeep J. Nathan, Eric R. Siemers, Paul Maruff, John Harrison

Journal: Drug Discovery Today

Year Published: 2021

Go/No-Go decision making in early phase clinical trials is challenging for drug developers working in Alzheimer’s disease. Recent negative trial results have been attributed to a lack of efficacy and important safety concerns. Furthermore, demonstrated target […]

Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia

Authors: Yen Ying Lim, Victor L Villemagne, Simon M Laws, Robert H Pietrzak, David Ames, Christopher Fowler, Stephanie Rainey-Smith, Peter J Snyder, Pierrick Bourgeat, Ralph N Martins, Olivier Salvado, Christopher C Rowe, Colin L Masters, Paul Maruff, AIBL Research Group

Journal: Journal of Molecular Neuroscience

Year Published: 2016

In a group of older adults with very mild dementia, we aimed to characterize the nature and magnitude of cognitive decline as measured by the Cogstate Brief Battery, in relation to Aβ levels and hippocampal volume. […]

Methodological Aspects of the Phase II Study AFF006 Evaluating Amyloid-beta -Targeting Vaccine AFFITOPE® AD02 in Early Alzheimer’s Disease – Prospective Use of Novel Composite Scales

Authors: S Hendrix, N Ellison, S Stanworth, L Tierney, F Mattner, W Schmidt, B Dubois, A Schneeberger

Journal: The Journal of Prevention of Alzheimer's Disease

Year Published: 2016

Background: Optimized scales and composite outcomes have been proposed as a way to more accurately measure Alzheimer’s disease related decline. AFFITOPE® AD02, is an amyloid-beta (Aβ)-targeting vaccine to elicit anti-Aβ antibodies. IMM-AD04, commonly known as Alum, […]

1 2 3

Back to Publications