alzheimer's disease

Lorazepam Challenge for Individuals at Varying Genetic Risk for Alzheimer Disease

Authors: Cynthia M Stonnington, Brian Harel, Dona E C Locke, Joseph G Hentz, Nan Zhang, Paul Maruff, Richard J Caselli

Journal: Alzheimer Disease and Associated Disorders

Year Published: 2017

Introduction: This study set out to clarify the differential acute cognitive impact of lorazepam based on varying genetic risk for Alzheimer disease. Methods: Fifty-seven cognitively unimpaired individuals aged 51 to 88, genotyped according to apolipoprotein E […]

A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M 1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer’s disease

Authors: Pradeep J Nathan, S Babli Millais, Alex Godwood, Odile Dewit, David M Cross, Janet Liptrot, Bharat Ruparelia, Stephen Paul Jones, Geor Bakker, Paul T Maruff, Gregory A Light, Alastair J H Brown, Malcolm Peter Weir, Miles Congreve, Tim Tasker

Journal: Alzheimer's & Dementia : Translational Research & Clinical Interventions

Year Published: 2022

Introduction: This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild-to-moderate Alzheimer’s disease (AD) on background donepezil 10 mg/day. Methods: A randomized, double-blind, placebo-controlled 4-week […]

Elucidating the association between depression, anxiety, and cognition in middle-aged adults: Application of dimensional and categorical approaches

Authors: Stephanie Perin, Janice Lai, Matthew Pase, Lisa Bransby, Rachel Buckley, Nawaf Yassi, Robert H Pietrzak, Paul Maruff, Yen Ying Lim

Journal: Journal of Affective Disorders

Year Published: 2022

Background: In older adults, depressive and anxiety symptoms are associated with dementia risk, and represent a manifestation of the dementia prodrome. Understanding how these symptoms are related to cognition in midlife may inform risk models of […]

Brain health registry GenePool study: A novel approach to online genetics research

Authors: Juliet Fockler, Winnie Kwang, Miriam T Ashford, Derek Flenniken, Joshua Hwang, Diana Truran, R Scott Mackin, Chengshi Jin, Ruth O'Hara, Joachim F Hallmayer, Jerome A Yesavage, Michael W Weiner, Rachel L Nosheny

Journal: Alzheimer's & Dementia

Year Published: 2021

Introduction Remote data collection, including the establishment of online registries, is a novel approach to efficiently identify risk for cognitive decline and Alzheimer’s disease (AD) in older adults, with growing evidence for feasibility and validity. Addition […]

Online study partner-reported cognitive decline in the Brain Health Registry

Authors: Rachel L. Nosheny, Monica R. Camacho, Philip S. Insel, Derek Flenniken, Juliet Fockler, Diana Truran, Shannon Finley, Aaron Ulbricht, Paul Maruff, Kristine Yaffe, R. Scott Mackin, Michael W. Weiner, Alzheimer's Disease Neuroimaging Initiative

Journal: Alzheimer's & Dementia

Year Published: 2018

Introduction Methods for efficiently identifying cognitive decline and Alzheimer’s disease (AD) are a critical unmet need. The goal of this work was to validate novel online study partner (SP)-reported outcomes to identify cognitive decline in older […]

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