elderly

β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men.

Authors: Ames D, Dore V, Esterlis I, Holmes SE, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Mazure CM, Pietrzak RH, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL

Journal: The American Journal of Geriatric Psychiatry

OBJECTIVE: To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. METHODS: Cross-sectional data were analyzed from 423 older adults from the […]

Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months.

Authors: Ames D, Ellis KA, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Rainey-Smith SR, Rowe CC, Thai C, Villemagne VL

Journal: PloS One

High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. However, the relationship between these two biomarkers and […]

Detection of MCI in the clinic: Evaluation of the sensitivity and specificity of a computerised test battery, the Hopkins Verbal Learning Test and the MMSE.

Authors: Budge MM, de Jager CA, Honey TE, Schrijnemaekers AC

Journal: Age Ageing

INTRODUCTION: The sensitive detection of mild cognitive impairment (MCI) in older adults is an important problem that requires objective assessment. We evaluated whether the computerised cognitive test battery, CogState, was as sensitive to MCI as two […]

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