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Hippocampal segmentation for brains with extensive atrophy using three-dimensional convolutional neural networks.

Authors: Adamo S, Akhavein H, Black SE, Gao F, Goubran M, Holmes M, MacIntosh B, Martel A, Masellis M, Nestor S, Ntiri EE, Ozzoude M, Ramirez J, Scott C, Swardfager W, Swartz R

Journal: Human brain mapping

DOI: 10.1002/hbm.24811

Year Published: 2020

Hippocampal volumetry is a critical biomarker of aging and dementia, and it is widely used as a predictor of cognitive performance; however, automated hippocampal segmentation methods are limited because the algorithms are (a) not publicly available, (b) subject to error with significant brain atrophy, cerebrovascular disease and lesions, and/or (c) computationally expensive or require parameter […]

Greater Circulating Copper Concentrations and Copper/Zinc Ratios are Associated with Lower Psychological Distress, But Not Cognitive Performance, in a Sample of Australian Older Adults.

Authors: Cardoso BR, Daly RM, Formica M, Gianoudis J, Mravunac M, Nowson CA, O'Connell SL, Roberts BR, Szymlek-Gay EA

Journal: Nutrients

DOI: 10.3390/nu11102503

Year Published: 2019

Dyshomeostasis of copper and zinc is linked to neurodegeneration. This study investigated the relationship between circulating copper and zinc and copper/zinc ratios and cognitive function, symptoms of depression and anxiety, and neurotrophic factors in older Australian adults. In this cross-sectional study (n = 139), plasma copper, serum zinc, and neurotrophic factors (brain-derived neurotrophic factor (BDNF), […]

The relationship between peripheral hearing loss and higher order listening function on cognition in older Australians.

Authors: Dowell R, Nixon G, Sarant JZ, Tomlin D

Journal: International journal of audiology

DOI: 10.1080/14992027.2019.1641752

Year Published: 2019

Objective: Peripheral hearing, central auditory processing (CAP) and cognition are all important for comprehension of speech and deteriorate with increased age. This study aimed to examine the relation between hearing impairment and cognitive impairment by assessing both peripheral hearing impairment and CAP ability. Design: Cognition was measured using the CogState Brief Battery (CSBB). Peripheral hearing […]

Duration of preclinical, prodromal, and dementia stages of Alzheimer’s disease in relation to age, sex, and APOE genotype.

Authors: Blennow K, Bos I, Freund-Levi Y, Handels R, Kern S, Maruff P, Muniz-Terrera G, Olde Rikkert M, Ousset PJ, Scheltens P, Sikkes SAM, Skoog I, Soininen H, Spiru L, Tsolaki M, van den Hout A, van der Flier WM, Verhey FRJ, Vermunt L, Visser PJ, Wallin ÅK, Zetterberg H

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2019.04.001

Year Published: 2019

INTRODUCTION: We estimated the age-specific duration of the preclinical, prodromal, and dementia stages of Alzheimer’s disease (AD) and the influence of sex, setting, apolipoprotein E (APOE) genotype, and cerebrospinal fluid tau on disease duration. METHODS: We performed multistate modeling in a combined sample of 6 cohorts (n = 3268) with death as the end stage […]

Multifaceted intervention to enhance cognition in older people at risk of cognitive decline: study protocol for the Protein Omega-3 and Vitamin D Exercise Research (PONDER) study.

Authors: Brownell S, Daly RM, Duckham RL, Macpherson H, Meyer B, Mirzaee S

Journal: BMJ Open

DOI: 10.1136/bmjopen-2018-024145

Year Published: 2019

INTRODUCTION: An increasing number of people are living with cognitive impairment and dementia. Current pharmacological therapies at best reduce Alzheimer’s disease symptomatology but do not delay dementia onset in those at high risk. Structured exercise interventions can enhance cognition in older people; however, to produce long lasting, clinically relevant cognitive benefits, it is proposed that […]

Superior Memory Reduces 8-year Risk of Mild Cognitive Impairment and Dementia But Not Amyloid β-Associated Cognitive Decline in Older Adults.

Authors: Ames D, Dang C, Harrington KD, Hassenstab J, Hickey M, Laws SM, Lim YY, Maruff P, Masters CL, Rainey-Smith SR, Robertson J, Rowe CC, Salvado O, Sohrabi HR, Villemagne VL, Weinborn M, Yassi N

Journal: Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists

DOI: 10.1093/arclin/acy078

Year Published: 2019

OBJECTIVE: To prospectively examine 8-year risk of clinical disease progression to mild cognitive impairment (MCI)/dementia in older adults ≥60 with superior episodic memory (SuperAgers) compared to those cognitively normal for their age (CNFA). Additionally, to determine the extent to which SuperAgers were resilient to the negative effects of elevated amyloid-beta (Aβ+) on cognition. METHOD: Participants […]

Selenium Status Is Not Associated with Cognitive Performance: A Cross-Sectional Study in 154 Older Australian Adults.

Authors: Cardoso BR, Daly RM, Formica M, Gianoudis J, Nowson CA, O'Connell S, Roberts BR, Szymlek-Gay EA

Journal: Nutrients

DOI: 10.3390/nu10121847

Year Published: 2018

Selenium was suggested to play a role in modulating cognitive performance and dementia risk. Thus, this study aimed to investigate the association between selenium status and cognitive performance, as well as inflammatory and neurotrophic markers in healthy older adults. This cross-sectional study included 154 older adults (≥60 years) from Victoria, Australia. Participants were assessed for […]

Unsupervised online neuropsychological test performance for individuals with mild cognitive impairment and dementia: Results from the Brain Health Registry.

Authors: Bickford D, Comacho M, Finley S, Flenniken D, Harel B, Insel PS, Mackin RS, Maruff P, Nosheny R, Truran D, Ulbright A, Weiner MW

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.dadm.2018.05.005

Year Published: 2018

Introduction: The purpose of this study is to compare online neuropsychological test performance of older adults across self-reported diagnoses of being cognitively normal, mild cognitive impairment, and dementia due to Alzheimer’s disease and to determine the association of memory concerns and family history of dementia on cognitive performance. Methods: Participants completed the Cogstate Brief Battery […]

Relationship Between Amyloid-β Positivity and Progression to Mild Cognitive Impairment or Dementia over 8 Years in Cognitively Normal Older Adults.

Authors: Ames D, Dang C, Harrington KD, Hassenstab J, Hickey M, Laws SM, Lim YY, Maruff P, Masters CL, Rainey-Smith S, Robertson J, Rowe CC, Salvado O, Sohrabi HR, Villemagne VL, Weinborn M, Yassi N

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-180507

Year Published: 2018

BACKGROUND: Preclinical Alzheimer’s disease (AD) is defined by cerebral amyloid-β positivity (Aβ+) in cognitively normal (CN) older adults. OBJECTIVE: To estimate the risk of progression to the symptomatic stages of AD due to PET Aβ+ and the extent that progression was influenced by other demographic, genetic, and clinical characteristics in a large prospective study. METHODS: Fine-Gray […]

Patient perspectives of the experience of a computerized cognitive assessment in a clinical setting.

Authors: Feng TL, Hayden S, Lai JA, Robillard JM, Wu JM

Journal: Alzheimer's and Dementia

DOI: 10.1016/j.trci.2018.06.003

Year Published: 2018

Introduction: Computerized assessments are becoming widely accepted in the clinical setting and as a potential outcome measure in clinical trials. To gain patient perspectives of this experience, the aim of the present study was to investigate patient attitudes and perceptions of the Cognigram [Cogstate], a computerized cognitive assessment. Methods: Semi-structured interviews were conducted with 19 […]

BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer’s disease.

Authors: Allegri R, Bateman RJ, Benzinger TL, Chhatwal J, Cruchaga C, Fagan AM, Farlow MR, Goate A, Graff-Radford NR, Hassenstab J, Holtzman DM, Laske C, Levin J, Lim YY, Maruff P, Masters CL, McDade E, Morris JC, Ringman JM, Rossor M, Salloway S, Schofield PR, Snyder PJ

Journal: Brain

Year Published: 2016

SEE ROGAEVA AND SCHMITT-ULMS DOI101093/AWW201 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is implicated in synaptic excitation and neuronal integrity, and has previously been shown to moderate amyloid-β-related memory decline and hippocampal atrophy in preclinical sporadic Alzheimer’s disease. However, the effect of BDNF in autosomal dominant Alzheimer’s disease […]

Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures used Across 19 International Research Studies.

Authors: Amariglio RE, Berman LM, Boada M, Buckley RF, Chételat G, Crane PK, Dubois B, Ellis KA, Gifford KA, Jefferson AL, Jessen F, Katz MJ, Lipton RB, Luck T, Maruff P, Mielke MM, Molinuevo JL, Naeem F, Perrotin A, Petersen RC, Rabin LA, Rami L, Reisberg B, Rentz DM, Riedel-Heller SG, Risacher SL, Rodriguez O, Sachdev PS, Saykin AJ, Sikkes SA, Slavin MJ, Smart CM, Snitz BE, Sperling RA, Tandetnik C, van der Flier WM, Wagner M, Wolfsgruber S

Journal: Journal of Alzheimer's Disease

Year Published: 2015

Research increasingly suggests that subjective cognitive decline (SCD) in older adults, in the absence of objective cognitive dysfunction or depression, may be a harbinger of non-normative cognitive decline and eventual progression to dementia. Little is known, however, about the key features of self-report measures currently used to assess SCD. The Subjective Cognitive Decline Initiative (SCD-I) […]

Status of computerized cognitive testing in aging: a systematic review.

Authors: Howieson D, Kaye J, Seelye A, Webbe F, Wild K

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2008.07.003

Year Published: 2008

BACKGROUND: Early detection of cognitive decline in the elderly has become of heightened importance in parallel with the recent advances in therapeutics. Computerized assessment might be uniquely suited to early detection of changes in cognition in the elderly. We present here a systematic review of the status of computer-based cognitive testing, focusing on detection of […]

Reliability of repeated cognitive assessment of dementia using a brief computerized battery.

Authors: Albin R, Barbas N, Darby D, Frey K, Giordani B, Hammers D, Heidebrink J, Persad C, Ryan K, Spurgeon E

Journal: American Journal of Alzheimer's Disease and Other Dementias

DOI: 10.1177/1533317511411907

Year Published: 2011

OBJECTIVE: The aim of this study was to evaluate the short-term stability and reliability of a brief computerized cognitive battery in established dementia types. METHOD: Patients were administered the computerized battery twice with administrations approximately 2 hours apart, with intervening conventional neuropsychological tests. Patients were classified clinically, via consensus conference, as healthy controls (n = […]

Use of an experimental language acquisition paradigm for standardized neuropsychological assessment of learning: A pilot study in young and older adults.

Authors: Baker JE, Bruns L Jr, Hassenstab J, Lim YY, Maruff P, Masters CL

Journal: Journal of Clinical and Experimental Neuropsychology

DOI: 10.1080/13803395.2019.1665626

Year Published: 2020

Introduction: Despite the numerous episodic memory tasks used in neuropsychological assessment, relatively few learning tasks are available, with methods lacking the complexity and sophistication to capture very subtle changes in information acquisition. Method: We adapted a previously validated associative learning task for use within an online framework, utilizing real-world stimuli, in which learning of audio-visual […]

Hippocampal segmentation for brains with extensive atrophy using three-dimensional convolutional neural networks.

Authors: Adamo S, Akhavein H, Black SE, Gao F, Goubran M, Holmes M, MacIntosh B, Martel A, Masellis M, Nestor S, Ntiri EE, Ozzoude M, Ramirez J, Scott C, Swardfager W, Swartz R

Journal: Human brain mapping

DOI: 10.1002/hbm.24811

Year Published: 2020

Hippocampal volumetry is a critical biomarker of aging and dementia, and it is widely used as a predictor of cognitive performance; however, automated hippocampal segmentation methods are limited because the algorithms are (a) not publicly available, (b) subject to error with significant brain atrophy, cerebrovascular disease and lesions, and/or (c) computationally expensive or require parameter […]

Identification of Pre-Clinical Alzheimer’s Disease in a Population of Elderly Cognitively Normal Participants.

Authors: Doecke JD, Maruff P, Mengersen K, Rousseau J, van Havre Z, Villemagne VL, White N

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191095

Year Published: 2020

Alzheimer’s disease (AD) has a long pathological process, with an approximate lead-time of 20 years. During the early stages of the disease process, little evidence of the building pathology is identifiable without cerebrospinal fluid and/or imaging analyses. Clinical manifestations of AD do not present until irreversible pathological changes have occurred. Given an opportunity to provide […]

The Effect of Hearing Aid Use on Cognition in Older Adults: Can We Delay Decline or Even Improve Cognitive Function?

Authors: Busby P, Harris D, Launer S, Lemke U, Maruff P, Sarant J, Schembri A

Journal: Journal of clinical medicine

DOI: 10.3390/jcm9010254

Year Published: 2020

Hearing loss is a modifiable risk factor for dementia in older adults. Whether hearing aid use can delay the onset of cognitive decline is unknown. Participants in this study (aged 62-82 years) were assessed before and 18 months after hearing aid fitting on hearing, cognitive function, speech perception, quality of life, physical activity, loneliness, isolation, […]

Associations of Apolipoprotein E ε4 Genotype and Ball Heading With Verbal Memory in Amateur Soccer Players.

Authors: Davies P, Freudenberg-Hua Y, Hu S, Hunter LE, Kim M, Lipton ML, Lipton RB, Srinivasan P, Stewart WF

Journal: JAMA Neurology

DOI: 10.1001/jamaneurol.2019.4828

Year Published: 2020

Importance: Emerging evidence suggests that long-term exposure to ball heading in soccer, the most popular sport in the world, confers risk for adverse cognitive outcomes. However, the extent to which the apolipoprotein E ε4 (APOE ε4) allele, a common risk factor for neurodegeneration, and ball heading are associated with cognition in soccer players remains unknown. […]

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Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance.

Authors: Ames D, Dang C, Doecke JD, Fripp J, Harrington KD, Hickey M, Laws SM, Lim YY, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Salvado O, Snyder PJ, Sohrabi HR, Villemagne VL, Weinborn M, Xia Y, Yassi N

Journal: Alzheimer's & dementia : diagnosis assessment & disease monitoring

DOI: 10.1016/j.dadm.2019.05.005

Year Published: 2019

Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older […]

SuperAging: Current findings yield future challenges-A response to Rogalski and Goldberg.

Authors: Dang C, Maruff P

Journal: Alzheimer's & dementia : diagnosis assessment & disease monitoring

DOI: 10.1016/j.dadm.2019.05.004

Year Published: 2019

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Influence of Comorbidity of Cerebrovascular Disease and Amyloid-β on Alzheimer’s Disease.

Authors: Ames D, Chen C, Desmond PM, Fowler C, Hilal S, Kuijf H, Lim YY, Martins R, Maruff P, Masters CL, Rowe C, Salvado O, Villemagne V, Watson R, Xia Y, Yassi N, Yates P

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191028

Year Published: 2019

BACKGROUND: Quantifying the contribution of cerebrovascular disease to the clinical and pathological profile of Alzheimer’s disease is challenging. OBJECTIVE: We aimed to determine the influence of cerebrovascular disease, amyloid-β (Aβ), and their comorbidity on cognitive decline, hippocampal atrophy, and Aβ deposition, by evaluating data from the Australian Imaging, Biomarker and Lifestyle Study of Ageing. METHODS: […]

Identification of Pre-Clinical Alzheimer’s Disease in a Population of Elderly Cognitively Normal Participants.

Authors: Doecke JD, Maruff P, Mengersen K, Rousseau J, van Havre Z, Villemagne V, White N

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191095

Year Published: 2019

Alzheimer’s disease (AD) has a long pathological process, with an approximate lead-time of 20 years. During the early stages of the disease process, little evidence of the building pathology is identifiable without cerebrospinal fluid and/or imaging analyses. Clinical manifestations of AD do not present until irreversible pathological changes have occurred. Given an opportunity to provide […]

C-reactive protein and response to lurasidone treatment in children and adolescents with bipolar I depression: Results from a placebo-controlled trial.

Authors: Loebel A, Pikalov A, Raison CL, Siu C, Tocco M

Journal: Brain behavior and immunity

DOI: 10.1016/j.bbi.2019.12.010

Year Published: 2019

This study sought to investigate associations between levels of high-sensitivity c-reactive protein (hsCRP) prior to treatment and change in depressive symptoms and cognition in a short-term, double-blind, placebo-controlled study of lurasidone in children and adolescents with bipolar I depression. Patients 10-17 years of age with a DSM-5 diagnosis of bipolar I depression were randomized to […]

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Neuropsychological Trajectories Associated with Adolescent Alcohol and Cannabis Use: A Prospective 14-Year Study.

Authors: Coronado C, Courtney KE, Infante MA, Jacobus J, Nguyen-Louie TT, Worley M

Journal: Journal of the International Neuropsychological Society : JINS

DOI: 10.1017/S1355617719001395

Year Published: 2019

OBJECTIVES: Alcohol and cannabis remain the substances most widely used by adolescents. Better understanding of the dynamic relationship between trajectories of substance use in relation to neuropsychological functioning is needed. The aim of this study was to examine the different impacts of within- and between-person changes in alcohol and cannabis use on neuropsychological functioning over […]

Effects of transcranial direct current stimulation on cognition and symptoms in Chinese patients with schizophrenia✰.

Authors: Davis JM, Faull R, Jiang J, Jin H, Li C, Md WL, Smith RC, Szabo V, Wang J, Wang Y

Journal: Psychiatry Research

DOI: 10.1016/j.psychres.2019.112617

Year Published: 2019

There is preliminary evidence that transcranial direct current stimulation(tDCS) may improve symptoms and cognitive function in schizophrenia, but the generalizability of these results needs further investigation. We present a study of the effects of active vs. sham tDCS on cognition and symptoms in a sample of 45 Chinese patients with schizophrenia who showed significant cognitive […]

Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD.

Authors: Amariglio RE, Buckley R, Johnson KA, Maruff P, Masters CL, Mormino E, Papp KV, Rentz DM, Sperling RA, Villemagne VL

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2019.09.074

Year Published: 2019

INTRODUCTION: Demonstrating the “clinical meaningfulness” of slowing early cognitive decline in clinically normal (CN) older adults with elevated amyloid-β (Aβ+) is critical for Alzheimer’s disease secondary prevention trials and for understanding early cognitive progression. METHODS: Cox regression analyses were used to determine whether 3-year slopes on the preclinical Alzheimer’s cognitive composite predicted MCI diagnosis and […]

Computerized cognitive performance assessments in the Brooklyn Cognitive Impairments in Health Disparities Pilot Study.

Authors: Adler K, Apple S, Cheng F, Cohen C, Friedlander A, Gustafson D, Levine SR, Lucchesi M, Maruff P, Reinhardt M, Salmieri M, Stevens D, Weingast S

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2019.07.004

Year Published: 2019

INTRODUCTION: Detecting cognitive impairment in diverse, health disparities communities is an urgent health care priority. METHODS: The Brooklyn Cognitive Impairments in Health Disparities Pilot Study investigated quantitative aspects and liking of a computerized cognitive performance assessment, Cognigram, among individuals ≥ 40 years in traditional and nontraditional primary care settings. RESULTS: Cognigram was piloted in the […]

Health-related quality of life, emotional burden, and neurocognitive function in the first generation of metastatic melanoma survivors treated with pembrolizumab: a longitudinal pilot study.

Authors: Awada G, De Cremer J, De Ridder M, Leys C, Neyns B, Rogiers A, Schembri A, Theuns P

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

DOI: 10.1007/s00520-019-05168-3

Year Published: 2019

PURPOSE: The aim of this study was to assess the evolution of health-related quality of Life (HRQoL), emotional burden, and neurocognitive function in the first-generation metastatic melanoma survivors treated with pembrolizumab. METHODS: Survivors were defined as patients who achieved a durable remission for at least 6 months after initiating pembrolizumab in a single-center observational study […]