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Long-term cognitive outcomes in male and female athletes following sport-related concussions.

Authors: Ellemberg D, Moore RD, Sicard V

Journal: International Journal of Psychophysiology

DOI: 10.1016/j.ijpsycho.2018.03.011

Year Published: 2018

Despite concussion being a serious public health concern and the increasing participation of female athletes in sport, the comparative long-term outcomes of male and female athletes are poorly understood, potentially limiting the scientific understanding and clinical management of these injuries. We examined whether sex influences the long-term cognitive outcomes in athletes with a history of […]

Long-term cognitive outcomes in male and female athletes following sport-related concussions.

Authors: Ellemberg D, Moore RD, Sicard V

Journal: International Journal of Psychophysiology

DOI: 10.1016/j.ijpsycho.2018.03.011

Year Published: 2018

Despite concussion being a serious public health concern and the increasing participation of female athletes in sport, the comparative long-term outcomes of male and female athletes are poorly understood, potentially limiting the scientific understanding and clinical management of these injuries. We examined whether sex influences the long-term cognitive outcomes in athletes with a history of […]

Sensitivity of the Cogstate Test Battery for Detecting Prolonged Cognitive Alterations Stemming From Sport-Related Concussions.

Authors: Ellemberg D, Moore RD, Sicard V

Journal: Clinical Journal of Sport Medicine

DOI: 10.1097/JSM.0000000000000492

Year Published: 2017

OBJECTIVE: To determine if the Cogstate test battery contains the requisite sensitivity to detect prolonged cognitive alterations. METHODS: One hundred twenty collegiate athletes (71 with a history of concussion; 49 controls) completed the Cogstate test battery, to which we added a 2-back condition. In addition to the Cogstate clinical (transformed variables), we analyzed the raw […]

Brain Network Activation Technology Does Not Assist with Concussion Diagnosis and Return to Play in Football Athletes.

Authors: Broglio SP, Eckner JT, Lapointe A, Meehan SK, Moore B, Rettmann A, Williams R

Journal: Frontiers in Neurology

DOI: 10.3389/fneur.2017.00252

Year Published: 2017

BACKGROUND: Concussion diagnosis and management remains a largely subjective process. This investigation sought to evaluate the utility of a novel neuroelectric measure for concussion diagnosis and return to play decision-making. HYPOTHESIS: Brain Network Activation (BNA) scores obtained within 72-h of injury will be lower than the athlete’s preseason evaluation and that of a matched control […]

Approach to investigation and treatment of persistent symptoms following sport-related concussion: a systematic review.

Authors: Feddermann-Demont N, Guskiewicz KM, Hinds S, Johnston KM, Leddy JJ, Makdissi M, McCrea M, Schneider KJ, Turner M

Journal: British Journal of Sports Medicine

DOI: 10.1136/bjsports-2016-097470

Year Published: 2017

OBJECTIVE: To conduct a systematic review of the literature regarding assessment and treatment modalities in patients with persistent symptoms following sport-related concussion (SRC). DATA SOURCES: We searched Medline, Embase, SPORTSDiscus, PsycINFO, CINAHL, Cochrane library and ProQuest Dissertation & Theses Global electronic databases. STUDY ELIGIBILITY CRITERIA: Studies were included if they were original research, reported on […]

The Berlin 2016 process: a summary of methodology for the 5th International Consensus Conference on Concussion in Sport.

Authors: Dvorak J, Finch CF, Hayden KA, Mccrory P, Meeuwisse WH, Omu OT, Schneider KJ

Journal: British Journal of Sports Medicine

DOI: 10.1136/bjsports-2017-097569

Year Published: 2017

The purpose of this paper is to summarise the methodology for the 5th International Consensus Conference on Concussion in Sport. The 18 months of preparation included engagement of a scientific committee, an expert panel of 33 individuals in the field of concussion and a modified Delphi technique to determine the primary questions to be answered. […]

A Comparison of Four Computerized Neurocognitive Assessment Tools to a Traditional Neuropsychological Test Battery in Service Members with and without Mild Traumatic Brain Injury.

Authors: Arrieux JP, Cole WR, Ivins BJ, Qashu FM, Schwab KA

Journal: Archives of Clinical Neuropsychology

DOI: 10.1093/arclin/acx036

Year Published: 2017

Objective: Computerized neurocognitive assessment tools (NCATS) are often used as a screening tool to identify cognitive deficits after mild traumatic brain injury (mTBI). However, differing methodology across studies renders it difficult to identify a consensus regarding the validity of NCATs. Thus, studies where multiple NCATs are administered in the same sample using the same methodology […]

Rest and treatment/rehabilitation following sport-related concussion: a systematic review.

Authors: Feddermann-Demont N, Guskiewicz KM, Hayden A, Iverson GL, Leddy JJ, Makdissi M, McCrea M, Schneider KJ, Seifert T, Silverberg ND

Journal: British Journal of Sports Medicine

DOI: 10.1136/bjsports-2016-097475

Year Published: 2017

AIM OR OBJECTIVE: The objective of this systematic review was to evaluate the evidence regarding rest and active treatment/rehabilitation following sport-related concussion (SRC). DESIGN: Systematic review. DATA SOURCES: MEDLINE (OVID), CINAHL (EbscoHost), PsycInfo (OVID), Cochrane Central Register of Controlled Trials (OVID), SPORTDiscus (EbscoHost), EMBASE (OVID) and Proquest DissertationsandTheses Global (Proquest) were searched systematically. ELIGIBILITY CRITERIA […]

Prospective, Head-to-Head Study of Three Computerized Neurocognitive Assessment Tools (CNTs): Reliability and Validity for the Assessment of Sport-Related Concussion.

Authors: Barr WB, Guskiewicz K, Hammeke TA, LaRoche AA, Lerner EB, McCrea MA, Nelson LD, Pfaller AY, Randolph C

Journal: Journal of the International Neuropsychological Society

DOI: 10.1017/S1355617715001101

Year Published: 2016

Limited data exist comparing the performance of computerized neurocognitive tests (CNTs) for assessing sport-related concussion. We evaluated the reliability and validity of three CNTs-ANAM, Axon Sports/Cogstate Sport, and ImPACT-in a common sample. High school and collegiate athletes completed two CNTs each at baseline. Concussed (n=165) and matched non-injured control (n=166) subjects repeated testing within 24 […]

Comparison of Cognitive Performance on the Cogstate Brief Battery When Taken In-Clinic, In-Group, and Unsupervised.

Authors: Brunwin JW, Crawford CD, Cromer JA, Harel BT, Maruff P, Mayes LC, Valadka JS, Yu K

Journal: The Clinical Neuropsychologist

DOI: 10.1080/13854046.2015.1054437

Year Published: 2015

OBJECTIVE: Repeat cognitive assessment comparing post-injury performance to a pre-injury baseline is common in concussion management. Although post-injury tests are typically administered in clinical settings, baseline tests may be conducted individually with one-on-one supervision, in a group with supervision, or without supervision. The extent to which these different test settings affect cognitive performance is not […]

Computerised cognitive assessment of concussed Australian Rules footballers.

Authors: Bennell K, Bush A, Collie A, Darby DG, Makdissi M, Maruff P, Mccrory P

Journal: British Journal of Sports Medicine

DOI: 10.1136/bjsm.35.5.354

Year Published: 2001

BACKGROUND: “Paper and pencil” neuropsychological tests play an important role in the management of sports related concussions. They provide objective information on the athlete’s cognitive function and thus facilitate decisions on safe return to sport. It has been proposed that computerised cognitive tests have many advantages over such conventional tests, but their role in this […]

CogSport: reliability and correlation with conventional cognitive tests used in postconcussion medical evaluations.

Authors: Collie A, Darby D, Makdissi M, Maruff P, Mccrory P, McStephen M

Journal: Clinical Journal of Sport Medicine

Year Published: 2003

OBJECTIVE: To determine the repeatability of a computerized cognitive test designed to monitor recovery from concussion and assist team physicians make return to play decisions (CogSport). To determine the correlation between CogSport and two conventional neuropsychological tests. DESIGN: Prospective, serial investigation of cognitive function. SETTING: Professional and semi-professional Australian Football clubs and a university affiliated […]

Psychometric issues associated with computerised neuropsychological assessment of concussed athletes.

Authors: Collie A, Darby DG, Maruff P, McStephen M

Journal: British Journal of Sports Medicine

DOI: 10.1136/bjsm.37.6.556

Year Published: 2003

Psychometric issues associated with computerised neuropsychological assessment in sports concussion are put forward. Issues critical to ensuring test reliability and sensitivity are discussed, with particular reference to how inappropriate test design can affect clinical decision making.

Statistical procedures for determining the extent of cognitive change following concussion.

Authors: Collie A, Darby DG, Makdissi M, Maruff P, Mccrory P, McStephen M

Journal: British Journal of Sports Medicine

DOI: 10.1136/bjsm.2003.000293

Year Published: 2004

Neuropsychological (NP) testing is now often used to help to determine if the cognitive function of a concussed athlete has declined. The NP test score after concussion is compared with the baseline test score. Many clinicians simply subtract one from the other and make a clinical decision about the significance or otherwise of the resulting […]

Effect of concussion on clinically measured reaction time in 9 NCAA division I collegiate athletes: a preliminary study.

Journal: PM & R

DOI: 10.1016/j.pmrj.2010.12.003

Year Published: 2011

OBJECTIVES: To evaluate the effect of concussion on clinically measured reaction time (RT(clin)) and in comparison to a computerized reaction time measure (RT(comp)). DESIGN: Prospective, repeated measures observational study. SETTING: Athletic training clinic at a National Collegiate Athletic Association (NCAA) Division I university. PARTICIPANTS: Data are reported for 9 collegiate athletes with acute concussion who […]

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Use of an experimental language acquisition paradigm for standardized neuropsychological assessment of learning: A pilot study in young and older adults.

Authors: Baker JE, Bruns L Jr, Hassenstab J, Lim YY, Maruff P, Masters CL

Journal: Journal of Clinical and Experimental Neuropsychology

DOI: 10.1080/13803395.2019.1665626

Year Published: 2020

Introduction: Despite the numerous episodic memory tasks used in neuropsychological assessment, relatively few learning tasks are available, with methods lacking the complexity and sophistication to capture very subtle changes in information acquisition. Method: We adapted a previously validated associative learning task for use within an online framework, utilizing real-world stimuli, in which learning of audio-visual […]

Hippocampal segmentation for brains with extensive atrophy using three-dimensional convolutional neural networks.

Authors: Adamo S, Akhavein H, Black SE, Gao F, Goubran M, Holmes M, MacIntosh B, Martel A, Masellis M, Nestor S, Ntiri EE, Ozzoude M, Ramirez J, Scott C, Swardfager W, Swartz R

Journal: Human brain mapping

DOI: 10.1002/hbm.24811

Year Published: 2020

Hippocampal volumetry is a critical biomarker of aging and dementia, and it is widely used as a predictor of cognitive performance; however, automated hippocampal segmentation methods are limited because the algorithms are (a) not publicly available, (b) subject to error with significant brain atrophy, cerebrovascular disease and lesions, and/or (c) computationally expensive or require parameter […]

Identification of Pre-Clinical Alzheimer’s Disease in a Population of Elderly Cognitively Normal Participants.

Authors: Doecke JD, Maruff P, Mengersen K, Rousseau J, van Havre Z, Villemagne VL, White N

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191095

Year Published: 2020

Alzheimer’s disease (AD) has a long pathological process, with an approximate lead-time of 20 years. During the early stages of the disease process, little evidence of the building pathology is identifiable without cerebrospinal fluid and/or imaging analyses. Clinical manifestations of AD do not present until irreversible pathological changes have occurred. Given an opportunity to provide […]

The Effect of Hearing Aid Use on Cognition in Older Adults: Can We Delay Decline or Even Improve Cognitive Function?

Authors: Busby P, Harris D, Launer S, Lemke U, Maruff P, Sarant J, Schembri A

Journal: Journal of clinical medicine

DOI: 10.3390/jcm9010254

Year Published: 2020

Hearing loss is a modifiable risk factor for dementia in older adults. Whether hearing aid use can delay the onset of cognitive decline is unknown. Participants in this study (aged 62-82 years) were assessed before and 18 months after hearing aid fitting on hearing, cognitive function, speech perception, quality of life, physical activity, loneliness, isolation, […]

Associations of Apolipoprotein E ε4 Genotype and Ball Heading With Verbal Memory in Amateur Soccer Players.

Authors: Davies P, Freudenberg-Hua Y, Hu S, Hunter LE, Kim M, Lipton ML, Lipton RB, Srinivasan P, Stewart WF

Journal: JAMA Neurology

DOI: 10.1001/jamaneurol.2019.4828

Year Published: 2020

Importance: Emerging evidence suggests that long-term exposure to ball heading in soccer, the most popular sport in the world, confers risk for adverse cognitive outcomes. However, the extent to which the apolipoprotein E ε4 (APOE ε4) allele, a common risk factor for neurodegeneration, and ball heading are associated with cognition in soccer players remains unknown. […]

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Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance.

Authors: Ames D, Dang C, Doecke JD, Fripp J, Harrington KD, Hickey M, Laws SM, Lim YY, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Salvado O, Snyder PJ, Sohrabi HR, Villemagne VL, Weinborn M, Xia Y, Yassi N

Journal: Alzheimer's & dementia : diagnosis assessment & disease monitoring

DOI: 10.1016/j.dadm.2019.05.005

Year Published: 2019

Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older […]

SuperAging: Current findings yield future challenges-A response to Rogalski and Goldberg.

Authors: Dang C, Maruff P

Journal: Alzheimer's & dementia : diagnosis assessment & disease monitoring

DOI: 10.1016/j.dadm.2019.05.004

Year Published: 2019

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Influence of Comorbidity of Cerebrovascular Disease and Amyloid-β on Alzheimer’s Disease.

Authors: Ames D, Chen C, Desmond PM, Fowler C, Hilal S, Kuijf H, Lim YY, Martins R, Maruff P, Masters CL, Rowe C, Salvado O, Villemagne V, Watson R, Xia Y, Yassi N, Yates P

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191028

Year Published: 2019

BACKGROUND: Quantifying the contribution of cerebrovascular disease to the clinical and pathological profile of Alzheimer’s disease is challenging. OBJECTIVE: We aimed to determine the influence of cerebrovascular disease, amyloid-β (Aβ), and their comorbidity on cognitive decline, hippocampal atrophy, and Aβ deposition, by evaluating data from the Australian Imaging, Biomarker and Lifestyle Study of Ageing. METHODS: […]

Identification of Pre-Clinical Alzheimer’s Disease in a Population of Elderly Cognitively Normal Participants.

Authors: Doecke JD, Maruff P, Mengersen K, Rousseau J, van Havre Z, Villemagne V, White N

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191095

Year Published: 2019

Alzheimer’s disease (AD) has a long pathological process, with an approximate lead-time of 20 years. During the early stages of the disease process, little evidence of the building pathology is identifiable without cerebrospinal fluid and/or imaging analyses. Clinical manifestations of AD do not present until irreversible pathological changes have occurred. Given an opportunity to provide […]

C-reactive protein and response to lurasidone treatment in children and adolescents with bipolar I depression: Results from a placebo-controlled trial.

Authors: Loebel A, Pikalov A, Raison CL, Siu C, Tocco M

Journal: Brain behavior and immunity

DOI: 10.1016/j.bbi.2019.12.010

Year Published: 2019

This study sought to investigate associations between levels of high-sensitivity c-reactive protein (hsCRP) prior to treatment and change in depressive symptoms and cognition in a short-term, double-blind, placebo-controlled study of lurasidone in children and adolescents with bipolar I depression. Patients 10-17 years of age with a DSM-5 diagnosis of bipolar I depression were randomized to […]

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Neuropsychological Trajectories Associated with Adolescent Alcohol and Cannabis Use: A Prospective 14-Year Study.

Authors: Coronado C, Courtney KE, Infante MA, Jacobus J, Nguyen-Louie TT, Worley M

Journal: Journal of the International Neuropsychological Society : JINS

DOI: 10.1017/S1355617719001395

Year Published: 2019

OBJECTIVES: Alcohol and cannabis remain the substances most widely used by adolescents. Better understanding of the dynamic relationship between trajectories of substance use in relation to neuropsychological functioning is needed. The aim of this study was to examine the different impacts of within- and between-person changes in alcohol and cannabis use on neuropsychological functioning over […]

Effects of transcranial direct current stimulation on cognition and symptoms in Chinese patients with schizophrenia✰.

Authors: Davis JM, Faull R, Jiang J, Jin H, Li C, Md WL, Smith RC, Szabo V, Wang J, Wang Y

Journal: Psychiatry Research

DOI: 10.1016/j.psychres.2019.112617

Year Published: 2019

There is preliminary evidence that transcranial direct current stimulation(tDCS) may improve symptoms and cognitive function in schizophrenia, but the generalizability of these results needs further investigation. We present a study of the effects of active vs. sham tDCS on cognition and symptoms in a sample of 45 Chinese patients with schizophrenia who showed significant cognitive […]

Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD.

Authors: Amariglio RE, Buckley R, Johnson KA, Maruff P, Masters CL, Mormino E, Papp KV, Rentz DM, Sperling RA, Villemagne VL

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2019.09.074

Year Published: 2019

INTRODUCTION: Demonstrating the “clinical meaningfulness” of slowing early cognitive decline in clinically normal (CN) older adults with elevated amyloid-β (Aβ+) is critical for Alzheimer’s disease secondary prevention trials and for understanding early cognitive progression. METHODS: Cox regression analyses were used to determine whether 3-year slopes on the preclinical Alzheimer’s cognitive composite predicted MCI diagnosis and […]

Computerized cognitive performance assessments in the Brooklyn Cognitive Impairments in Health Disparities Pilot Study.

Authors: Adler K, Apple S, Cheng F, Cohen C, Friedlander A, Gustafson D, Levine SR, Lucchesi M, Maruff P, Reinhardt M, Salmieri M, Stevens D, Weingast S

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2019.07.004

Year Published: 2019

INTRODUCTION: Detecting cognitive impairment in diverse, health disparities communities is an urgent health care priority. METHODS: The Brooklyn Cognitive Impairments in Health Disparities Pilot Study investigated quantitative aspects and liking of a computerized cognitive performance assessment, Cognigram, among individuals ≥ 40 years in traditional and nontraditional primary care settings. RESULTS: Cognigram was piloted in the […]

Health-related quality of life, emotional burden, and neurocognitive function in the first generation of metastatic melanoma survivors treated with pembrolizumab: a longitudinal pilot study.

Authors: Awada G, De Cremer J, De Ridder M, Leys C, Neyns B, Rogiers A, Schembri A, Theuns P

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

DOI: 10.1007/s00520-019-05168-3

Year Published: 2019

PURPOSE: The aim of this study was to assess the evolution of health-related quality of Life (HRQoL), emotional burden, and neurocognitive function in the first-generation metastatic melanoma survivors treated with pembrolizumab. METHODS: Survivors were defined as patients who achieved a durable remission for at least 6 months after initiating pembrolizumab in a single-center observational study […]