Relationship Between Amyloid-β Positivity and Progression to Mild Cognitive Impairment or Dementia over 8 Years in Cognitively Normal Older Adults.

Authors: Ames D, Dang C, Harrington KD, Hassenstab J, Hickey M, Laws SM, Lim YY, Maruff P, Masters CL, Rainey-Smith S, Robertson J, Rowe CC, Salvado O, Sohrabi HR, Villemagne VL, Weinborn M, Yassi N

Journal: Journal of Alzheimer's disease : JAD

BACKGROUND: Preclinical Alzheimer’s disease (AD) is defined by cerebral amyloid-β positivity (Aβ+) in cognitively normal (CN) older adults. OBJECTIVE: To estimate the risk of progression to the symptomatic stages of AD due to PET Aβ+ and […]

The National Institute on Aging and the Alzheimer’s Association Research Framework for Alzheimer’s disease: Perspectives from the Research Roundtable.

Authors: Bain LJ, Canniere MZ, Carrillo MC, Haeberlein SB, Hendrix JA, Jack CR Jr, Kerchner G, Knopman DS, Kolb H, Margolin R, Maruff P, Mattsson N, Miller DS, Montine TJ, Murray ME, Nelson PT, Petersen RC, Resnick SM, Romano G, Sano M, Schneider JA, Siemers E, Sultzer DL, Tome MB, Tong G, van Harten AC, Vemuri P, Wolk DA

Journal: Alzheimer's and Dementia

The Alzheimer’s Association’s Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer’s Association Research Framework for Alzheimer’s disease. The meeting allowed experts in the field from academia, industry, […]

Nonvascular retinal imaging markers of preclinical Alzheimer’s disease.

Authors: Alber J, Fernández B, Johnson LN, Lim YY, Maruff P, Santos CY, Snyder PJ

Journal: Alzheimer's & Dementia

INTRODUCTION: In patients with Alzheimer’s disease (AD) and mild cognitive impairment, structural changes in the retina (i.e., reduced thicknesses of the ganglion cell and retinal nerve fiber layers and inclusion bodies that appear to contain beta-amyloid […]

Feasibility of baseline neurocognitive assessment using Cogstate during the first month of therapy for childhood leukemia.

Authors: Cole PD, Harel BT, Kelly K, Sands SA, Savone M, Silverman LB, Vijayanathan V, Vrooman L, Welch JG

Journal: Support Care Cancer

PURPOSE: Neurocognitive impairment is frequently observed among acute lymphoblastic leukemia (ALL) survivors within the domains of intelligence, attention, processing speed, working memory, learning, and memory. However, few have investigated treatment-induced changes in neurocognitive function during the […]

Predicting Alzheimer disease from a blood-based biomarker profile: A 54-month follow-up.

Authors: Ames D, Baker D, Burnham SC, Bush AI, Doecke JD, Faux NG, Laws SM, Macaulay SL, Martins RN, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Savage G, Villemagne VL, Wilson W

Journal: Neurology

OBJECTIVE: We assessed a blood-based signature, which previously demonstrated high accuracy at stratifying individuals with high or low neocortical β-amyloid burden (NAB), to determine whether it could also identify individuals at risk of progression to Alzheimer […]

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