Publications
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Memantine for Prevention of Cognitive Late Effects in Children and Adolescents Receiving Radiation Therapy for Brain Tumors: A Randomized, Controlled, Pilot Trial
Purpose: Children receiving irradiation for brain tumors are at significant risk for cognitive deficits that notably impact quality of life. This is the first randomized, controlled investigation of the feasibility, acceptability, and preliminary efficacy of memantine […]
Game-based Cognitive Training for School-age Children Living With or Exposed to HIV: A Randomized Controlled Trial in Uganda and Malawi
Objective: Children with perinatally acquired HIV (PHIV) and those exposed to HIV but uninfected (HEU) are at increased risk for adverse cognitive and behavioral outcomes, particularly in sub-Saharan Africa. This study evaluated the efficacy of brain […]
Exploring the repurposing potential of β2-adrenergic receptor agonists for cognitive function: Evidence from the PharmLines Initiative Retrospective Cohort Study
Background: Preclinical studies suggest β2-adrenergic receptor agonists may exert neuroprotective effects, but evidence in human populations is limited. Objective: To examine the association between β2-adrenergic receptor agonist use and cognitive performance in older adults. Methods: This […]
Associations of self-reported obstructive sleep apnea with cognition and dementia risk in cognitively unimpaired middle-aged adults
Introduction: Obstructive sleep apnea (OSA) is a potential risk factor for cognitive impairment and dementia; however, its contribution in midlife and interactions with APOE ε4 remain unclear. Methods: Participants were 2795 cognitively unimpaired, middle-aged adults enrolled […]
Response times from gap detection threshold testing relate to cognitive processing speed in young adults
Objective: In addition to a gap detection threshold, an auditory gap detection task also provides information on response time. This study investigated the association of response time from an adaptive gap detection task with two validated […]
