treatment-resistant depression

Effect of intranasal esketamine on cognitive functioning in healthy participants: a randomized, double-blind, placebo-controlled study

Authors: Randall L Morrison, Maggie Fedgchin, Jaskaran Singh, Joop Van Gerven, Rob Zuiker, Kyoung Soo Lim, Peter van der Ark, Ewa Wajs, Liwen Xi, Peter Zannikos, Wayne C Drevets

Journal: Psychopharmacology

Year Published: 2018

Background: The effect of intranasal esketamine on cognitive functioning in healthy participants is assessed in this study. Methods: Twenty-four participants (19-49 years) were randomized to one of two treatment sequences in which either esketamine 84 mg […]

Neurocognitive performance and serial intravenous subanesthetic ketamine in treatment-resistant depression

Authors: Paulo R Shiroma, C Sophia Albott, Brian Johns, Paul Thuras, Joseph Wels, Kelvin O Lim

Journal: The International Journal of Neuropsychopharmacology

Year Published: 2014

The N-methyl-D-aspartate glutamate receptor antagonist ketamine has demonstrated rapid antidepressant effects in treatment-resistant depression (TRD). However, evaluation of ketamine’s neurocognitive aspects in TRD has started to be explored. This study aims to (1) examine baseline neurocognitive […]

Back to Publications