Diagnostic and Prognostic Accuracy of the Cogstate Brief Battery and Auditory Verbal Learning Test in Preclinical Alzheimer’s Disease and Incident Mild Cognitive Impairment: Implications for Defining Subtle Objective Cognitive Impairment

Authors: Nikki H Stricker, Emily S Lundt, Sabrina M Albertson, Mary M Machulda, Shehroo B Pudumjee, Walter K Kremers, Clifford R Jack, David S Knopman, Ronald C Petersen, Michelle M Mielke

Journal: Journal of Alzheimer's Disease

Year Published: 2020

Background: There are detectable cognitive differences in cognitively unimpaired (CU) individuals with preclinical Alzheimer’s disease (AD). Objective: To determine whether cross-sectional performance on the Cogstate Brief Battery (CBB) and Auditory Verbal Learning Test (AVLT) could identify […]

A 24-week Study to Evaluate the Effect of Rilapladib on Cognition and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease

Authors: Gareth Maher-Edwards, Jeni De'Ath, Carly Barnett, Arseniy Lavrov, Andrew Lockhart

Journal: Alzheimer's & Dementia

Year Published: 2015

Background: The lipoprotein-associated phospholipase A2 inhibitor (Lp-PLA2), rilapladib (SB659032), is being evaluated as a potential treatment to slow the progression of Alzheimer’s disease (AD). Methods: One hundred twenty-four subjects with possible mild AD and with neuroimaging […]

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