Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer’s disease and mild cognitive impairment.

Authors: Chandra A, Cousins O, Dervenoulas G, Pagano G, Politis M, Valkimadi PE

Journal: Human brain mapping

Alzheimer’s disease (AD) is a devastating and progressive neurodegenerative disease for which there is no cure. Mild cognitive impairment (MCI) is considered a prodromal stage of the disease. Molecular imaging with positron emission tomography (PET) allows […]

The National Institute on Aging and the Alzheimer’s Association Research Framework for Alzheimer’s disease: Perspectives from the Research Roundtable.

Authors: Bain LJ, Canniere MZ, Carrillo MC, Haeberlein SB, Hendrix JA, Jack CR Jr, Kerchner G, Knopman DS, Kolb H, Margolin R, Maruff P, Mattsson N, Miller DS, Montine TJ, Murray ME, Nelson PT, Petersen RC, Resnick SM, Romano G, Sano M, Schneider JA, Siemers E, Sultzer DL, Tome MB, Tong G, van Harten AC, Vemuri P, Wolk DA

Journal: Alzheimer's and Dementia

The Alzheimer’s Association’s Research Roundtable met in November 2017 to explore the new National Institute on Aging and the Alzheimer’s Association Research Framework for Alzheimer’s disease. The meeting allowed experts in the field from academia, industry, […]

Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults.

Authors: Bruce D, Burnham S, Dore V, Fraser PE, Gaskin S, Laws SM, Li QX, Martins RN, Maruff P, Masters CL, Newsholme P, Porter T, Rainey-Smith S, Rowe CC, Salvado O, Srikanth V, Verdile G, Villemagne VL, Wijesekara N, Woodfield A

Journal: Scientific Reports

Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of developing dementia. Experimental evidence from mouse models demonstrates that the induction of T2D/insulin resistance (IR) can promote the accumulation of Alzheimer’s disease […]

BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer’s disease.

Authors: Allegri R, Bateman RJ, Benzinger TL, Chhatwal J, Cruchaga C, Fagan AM, Farlow MR, Goate A, Graff-Radford NR, Hassenstab J, Holtzman DM, Laske C, Levin J, Lim YY, Maruff P, Masters CL, McDade E, Morris JC, Ringman JM, Rossor M, Salloway S, Schofield PR, Snyder PJ

Journal: Brain

SEE ROGAEVA AND SCHMITT-ULMS DOI101093/AWW201 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism is implicated in synaptic excitation and neuronal integrity, and has previously been shown to moderate amyloid-β-related memory […]

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