AZD6280, a novel partial γ-aminobutyric acid A receptor modulator, demonstrates a pharmacodynamically selective effect profile in healthy male volunteers

Authors: Xia Chen, Gabriel Jacobs, Marieke L de Kam, Judith Jaeger, Jaakko Lappalainen, Paul Maruff, Mark A Smith, Alan J Cross, Adam Cohen, Joop van Gerven

Journal: Journal of Clinical Psychopharmacology

Year Published: 2015

Objective: AZD6280 is a novel γ-aminobutyric acid A receptor modulator with higher in vitro efficacy at the α2,3 subtypes as compared to the α1 and α5 subtypes. This study compared the pharmacodynamic effects of single oral […]

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