CD19/22 CAR T-cells in Children and Young Adults with B-ALL: Phase I Results and Development of a Novel Bicistronic CAR

Authors: Haneen Shalabi, Haiying Qin, Angela Su, Bonnie Yates, Pamela L. Wolters, Seth M Steinberg, John A Ligon, Sara Silbert, Kniya DéDé, Mehdi Benzaoui, Sophia Yael Goldberg, Sooraj Achar, Dina Schneider, Shilpa A Shahani, Lauren Little, Toni Foley, John C Molina, Sandhya Panch, Crystal L. Mackall, Daniel W. Lee, Christopher D Chien, Marie Pouzolles, Mark A Ahlman, Constance M Yuan, Hao-Wei Wang, Yanyu Wang, Jon Inglefield, Mary Anne Tamula, Staci Martin, Steven L Highfill, Gregoire Altan-Bonnet, David F Stroncek, Terry J Fry, Naomi Taylor, Nirali N Shah

Journal: Blood

Year Published: 2022

Remission durability following single-antigen targeted chimeric antigen receptor (CAR) T-cells is limited by antigen modulation, which may be overcome with combinatorial targeting. Building upon our experiences targeting CD19 and CD22 in B-cell acute lymphoblastic leukemia (B-ALL), […]

Reaction Times, Learning, and Executive Functioning in Adults Born Preterm

Authors: Julia Suikkanen, Satu Miettola, Kati Heinonen, Marja Vääräsmäki, Marjaana Tikanmäki, Marika Sipola, Hanna-Maria Matinolli, Marjo-Riitta Järvelin, Katri Räikkönen, Petteri Hovi & Eero Kajantie

Journal: Pediatric Research

Year Published: 2020

Background: This study examines cognitive functioning in adults born across the range of prematurity with appropriate or small for gestational age (SGA) birth weight compared with full-term controls. Methods: ESTER Preterm Birth Study participants without severe […]

C-reactive protein and response to lurasidone treatment in children and adolescents with bipolar I depression: Results from a placebo-controlled trial

Authors: Charles L. Raison, Cynthia Siu, Andrei Pikalov, Michael Tocco, Antony Loebel

Journal: Brain Behavior and Immunity

Year Published: 2019

This study sought to investigate associations between levels of high-sensitivity c-reactive protein (hsCRP) prior to treatment and change in depressive symptoms and cognition in a short-term, double-blind, placebo-controlled study of lurasidone in children and adolescents with […]

Computerized assessment of cognitive impairment among children undergoing radiation therapy for medulloblastoma

Authors: Andrew M. Heitzer, Jason M. Ashford, Brian T. Harel, Adrian Schembri, Michelle A. Swain, Joanna Wallace, Kirsten K. Ness, Fang Wang, Hui Zhang, Thomas E. Merchant, Giles W. Robinson, Amar Gajjar & Heather M. Conklin

Journal: Journal of Neuro-oncology

Year Published: 2019

Purpose: Advantages to computerized cognitive assessment include increased precision of response time measurement and greater availability of alternate forms. Cogstate is a computerized cognitive battery developed to monitor attention, memory, and processing speed. Although the literature […]

Ambulatory blood pressure monitoring and neurocognitive function in children with primary hypertension

Authors: Juan C Kupferman, Donald L Batisky, Joshua Samuels, Heather R Adams, Stephen R Hooper, Hongyue Wang, Marc B Lande

Journal: Pediatric Nephrology

Year Published: 2018

Background Children with primary hypertension have been reported to have diminished scores in measures of cognition. However, little is known about the relative correlation between office and ambulatory blood pressure (BP) and neurocognitive test performance, and […]

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