Access hundreds of peer-reviewed cognitive research papers published by leading neuroscientists using Cogstate technology.



Sleep and cognition in older adults: Does depression matter? An actigraphy and polysomnography study

Authors: Alix Mellor, Flavie Waters, Helen McGowan, Jennifer Maul, Katherine A. Sanders, Romola S. Bucks

Journal: Archives of Psychology

Volume & Issue: 2 & 1

Year Published: 2018

The impact of sleep on cognition is well recognised, although research in older adults is lacking, as are investigations into how depression might impact on this relationship. This study assessed the relationship between sleep (assessed with actigraphy and polysomnography) and cognitive performance in older adults (50–78 years) with (n = 10) and without (n = […]

A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort.

Authors: Ames D, Bush AI, Doecke J, Gupta VB, Hone E, James I, Martins RN, Masters CL, O'Bryant S, Pedrini S, Rowe CC, Villemagne VL

Journal: Scientific Reports

Volume & Issue: 7 & 1

Page No.: 14057

DOI: 10.1038/s41598-017-14020-9

Year Published: 2017

Alzheimer’s Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this […]

Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study.

Authors: Ames D, Dore V, Ellis K, Esterlis I, Fowler C, Holmes SE, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Mazure CM, Pietrzak RH, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL

Journal: International Journal of Geriatric Psychiatry

DOI: 10.1002/gps.4761

Year Published: 2017

OBJECTIVE: Depressive and anxiety symptoms are common in older adults, significantly affect quality of life, and are risk factors for Alzheimer’s disease. We sought to identify the determinants of predominant trajectories of depressive and anxiety symptoms in cognitively normal older adults. METHOD: Four hundred twenty-three older adults recruited from the general community underwent Aβ positron […]

Rapidly progressive Fronto-temporal dementia (FTD) associated with Frontotemporal lobar degeneration (FTLD) in the presence of Fused in Sarcoma (FUS) protein: a rare, sporadic, and aggressive form of FTD.

Authors: Ames D, Bradfield NI, Darby DG, Drago J, McLean C

Journal: International Psychogeriatrics / IPA

Volume & Issue: 29 & 10

Page No.: 1743-1746

DOI: 10.1017/S1041610217001193

Year Published: 2017

Fronto-temporal dementia (FTD) associated with Fused in Sarcoma (FUS) protein accumulation is an uncommon cause of FTD with a distinct syndrome of young age onset behavioral variant FTD, without a family history of FTD and caudate atrophy. We present a sporadic case of a 61-year-old patient with mixed features of both behavioral variant FTD with […]

Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment.

Authors: Anton S, Barrett-Connor E, Basaria S, Bhasin S, Cauley JA, Cella D, Cifelli D, Crandall JP, Cunningham GR, Diem SJ, Ellenberg SS, Ensrud KE, Farrar JT, Gill TM, Hou X, Lewis CE, Matsumoto AM, Molitch ME, Pahor M, Pleasants DD, Resnick SM, Shumaker SA, Snyder PJ, Stephens-Shields AJ, Swerdloff RS, Wang C

Journal: Journal of the American Medical Association

Volume & Issue: 317 & 7

Page No.: 717-727

DOI: 10.1001/jama.2016.21044

Year Published: 2017

Importance: Most cognitive functions decline with age. Prior studies suggest that testosterone treatment may improve these functions. Objective: To determine if testosterone treatment compared with placebo is associated with improved verbal memory and other cognitive functions in older men with low testosterone and age-associated memory impairment (AAMI). Design, Setting, and Participants: The Testosterone Trials (TTrials) […]

Plasma tau in Alzheimer disease.

Authors: Andreasson U, Baker D, Blennow K, Hanlon D, Hansson O, Insel PS, Janelidze S, Jeromin A, Mattsson N, Palmqvist S, Shaw LM, Song L, Stomrud E, Tan Hehir CA, Trojanowski JQ, Weiner MW, Zetterberg H

Journal: Neurology

DOI: 10.1212/WNL.0000000000003246

Year Published: 2016

OBJECTIVE: To test whether plasma tau is altered in Alzheimer disease (AD) and whether it is related to changes in cognition, CSF biomarkers of AD pathology (including β-amyloid [Aβ] and tau), brain atrophy, and brain metabolism. METHODS: This was a study of plasma tau in prospectively followed patients with AD (n = 179), patients with […]

Embolic protection in patients undergoing transaortic transcatheter aortic valve replacement: initial experience with the TriGuard HDH embolic deflection device.

Authors: Campelo-Parada F, DeLarochellière R, Doyle D, Dumont E, Mohammadi S, Paradis JM, Regueiro A, Rodés-Cabau J

Journal: Journal of Cardiac Surgery

Volume & Issue: 31 & 10

Page No.: 617-622

DOI: 10.1111/jocs.12822

Year Published: 2016

BACKGROUND: Stroke remains one of the most worrisome complications following transcatheter aortic valve replacement (TAVR). This pilot study evaluates the safety, feasibility, and exploratory efficacy of the TriGuard HDH embolic deflection device (Keystone Heart Ltd., Caesarea, Israel) in patients undergoing transaortic TAVR. METHODS: A total of 10 patients (median age: 81 years, STS score: 9.6 ± 5.6%) […]

Predicting Alzheimer disease from a blood-based biomarker profile: A 54-month follow-up.

Authors: Ames D, Baker D, Burnham SC, Bush AI, Doecke JD, Faux NG, Laws SM, Macaulay SL, Martins RN, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Savage G, Villemagne VL, Wilson W

Journal: Neurology

Volume & Issue: 87 & 11

Page No.: 1093-101

DOI: 10.1212/WNL.0000000000003094

Year Published: 2016

OBJECTIVE: We assessed a blood-based signature, which previously demonstrated high accuracy at stratifying individuals with high or low neocortical β-amyloid burden (NAB), to determine whether it could also identify individuals at risk of progression to Alzheimer disease (AD) within 54 months. METHODS: We generated the blood-based signature for 585 healthy controls (HCs) and 74 participants […]

The beneficial effects of cognitive training with simple calculation and reading aloud in an elderly postsurgical population: study protocol for a randomized controlled trial.

Authors: Hoshikawa Y, Kawashima R, Kulason K, Noda M, Nouchi R, Okada Y

Journal: Trials Journal

Volume & Issue: 17

Page No.: 334

DOI: 10.1186/s13063-016-1476-0

Year Published: 2016

BACKGROUND: This project proposes a pilot study to investigate the positive healing effects of cognitive training with simple arithmetic and reading aloud on elderly postsurgical patients. Elderly patients undergoing surgery have an increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly […]

Clinical and cognitive trajectories in cognitively healthy elderly individuals with suspected non-Alzheimer’s disease pathophysiology (SNAP) or Alzheimer’s disease pathology: a longitudinal study.

Authors: Ames D, Bourgeat P, Brown B, Burnham SC, Dore V, Laws S, Martins RN, Maruff P, Masters CL, Rowe CC, Salvado O, Savage G, Villemagne VL

Journal: The Lancet. Neurology

Volume & Issue: 15 & 10

Page No.: 1044-53

DOI: 10.1016/S1474-4422(16)30125-9

Year Published: 2016

BACKGROUND: Brain amyloid β (Aβ) deposition and neurodegeneration have been documented in about 50-60% of cognitively healthy elderly individuals (aged 60 years or older). The long-term cognitive consequences of the presence of Alzheimer’s disease pathology and neurodegeneration, and whether they have an independent or synergistic effect on cognition, are unclear. We aimed to characterise the […]

Effects of a Supplement Containing Apoaequorin on Verbal Learning in Older Adults in the Community.

Authors: Gabourie TA, Lerner KC, Moran DL, Underwood MY

Journal: Advances in Mind-Body Medicine

Volume & Issue: 30 & 1

Page No.: 4-11

Year Published: 2016

CONTEXT The changes in verbal learning and working memory that often occur with aging may result in reduced social and intellectual interactions. These changes significantly affect an individual’s quality of life. As humans age, the body’s ability to regulate and maintain calcium levels is diminished. Pharmacological manipulation of the entry of free calcium (Ca2+) has […]

Evaluation of a Self-Administered Computerized Cognitive Battery in an Older Population.

Authors: Grodstein F, Hagan KA, Koyama AK, Okereke OI, Rosner B, Weisskopf MG

Journal: Neuroepidemiology

Volume & Issue: 45 & 4

Page No.: 264-272

DOI: 10.1159/000439592

Year Published: 2015

OBJECTIVE: The aim of this study is to assess the utility of the Cogstate self-administered computerized neuropsychological battery in a large population of older men. METHODS: We invited 7,167 men (mean age of 75 years) from the Health Professionals Follow-up Study, a prospective cohort of male health professionals. We considered individual Cogstate scores and composite […]

Mild memory impairment in healthy older adults is distinct from normal aging.

Authors: Collie A, Maruff P, Masters C, Weaver Cargin J

Journal: Brain and cognition

Volume & Issue: 60 & 2

Page No.: 146-55

DOI: 10.1016/j.bandc.2005.10.004

Year Published: 2006

Mild memory impairment was detected in 28% of a sample of healthy community-dwelling older adults using the delayed recall trial of a word list learning task. Statistical analysis revealed that individuals with memory impairment also demonstrated relative deficits on other measures of memory, and tests of executive function, processing speed and global cognition, as measured […]

Detection of MCI in the clinic: Evaluation of the sensitivity and specificity of a computerised test battery, the Hopkins Verbal Learning Test and the MMSE.

Authors: Budge MM, de Jager CA, Honey TE, Schrijnemaekers AC

Journal: Age Ageing

Volume & Issue: 38 & 4

Page No.: 455-60

DOI: 10.1093/ageing/afp068

Year Published: 2009

INTRODUCTION: The sensitive detection of mild cognitive impairment (MCI) in older adults is an important problem that requires objective assessment. We evaluated whether the computerised cognitive test battery, CogState, was as sensitive to MCI as two well-validated ‘paper-and-pencil’ tests, the Hopkins Verbal Learning Test (HVLT) and the Mini-Mental Status Examination (MMSE). METHODS: These tests were […]

Subjective memory complaints, cognitive performance, and psychological factors in healthy older adults.

Authors: Arnold SE, Bogner H, Harel BT, Kling MA, Livney MG, McCoubrey H, Negash S, Sammel MD, Steinberg SI, Wolk DA

Journal: American Journal of Alzheimer's Disease and Other Dementias

Volume & Issue: 28 & 8

Page No.: 776-83

DOI: 10.1177/1533317513504817

Year Published: 2013

OBJECTIVE: To determine whether subjective memory complaints (SMCs) are associated with performance on objective cognitive measures and psychological factors in healthy, community-dwelling older adults. METHOD: The cohort was composed of adults, 65 years and older with no clinical evidence of cognitive impairment (n = 125). Participants were administered: CogState computerized neurocognitive battery, Prospective Retrospective Memory […]