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Longitudinal Comparison of in Clinic and at Home Administration of the Cogstate Brief Battery and Demonstrated Practice Effects in the Mayo Clinic Study of Aging.

Authors: Albertson SM, Alden EC, Knopman DS, Kremers WK, Lundt ES, Machulda MM, Mielke MM, Petersen RC, Stricker NH

Journal: The Journal of Prevention of Alzheimer's Disease

DOI: 10.14283/jpad.2019.35

Year Published: 2020

BACKGROUND: The Cogstate Brief Battery (CBB) is a computerized cognitive assessment that can be completed in clinic or at home. Design/Objective: This retrospective study investigated whether practice effects / performance trajectories of the CBB differ by location of administration. PARTICIPANTS/SETTING: Participants included 1439 cognitively unimpaired individuals age 50-75 at baseline participating in the Mayo Clinic […]

Preliminary exploration of a computerized cognitive battery and comparison with traditional testing in patients with high-grade glioma.

Authors: Anderson SK, Brown PD, Caine C, Cerhan JH, Johnson DR, Lachance DH, Yan E

Journal: Neuro-oncology practice

DOI: 10.1093/nop/npy013

Year Published: 2019

Background: Cognitive function is an important outcome measure in many brain tumor clinical trials, and investigators are interested in employing the most efficient methods of cognitive assessment for this purpose. Computerized testing can be appealing because of the perceived ease of use and electronic data generated. Traditional tests may have the advantage of accumulated validity […]

The feasibility, reliability and concurrent validity of the MSReactor computerized cognitive screening tool in multiple sclerosis.

Authors: Butzkueven H, Darby D, Kalincik T, Merlo D, Van der Walt A

Journal: Therapeutic advances in neurological disorders

DOI: 10.1177/1756286419859183

Year Published: 2019

Background: Multiple sclerosis (MS) cognitive tests are resource intensive and limited by practice effects that prevent frequent retesting. Brief, reliable and valid monitoring tools are urgently needed to detect subtle, subclinical cognitive changes in people with MS. Cognitive monitoring over time could contribute to a new definition of disease progression, supplementing routine clinical monitoring. Methods: […]

Computerized assessment of cognitive impairment among children undergoing radiation therapy for medulloblastoma.

Authors: Ashford JM, Conklin HM, Gajjar A, Harel BT, Heitzer AM, Merchant TE, Ness KK, Robinson GW, Schembri A, Swain MA, Wallace J, Wang F, Zhang H

Journal: Journal of Neuro-oncology

DOI: 10.1007/s11060-018-03046-2

Year Published: 2019

PURPOSE: Advantages to computerized cognitive assessment include increased precision of response time measurement and greater availability of alternate forms. Cogstate is a computerized cognitive battery developed to monitor attention, memory, and processing speed. Although the literature suggests the domains assessed by Cogstate are areas of deficit in children undergoing treatment for medulloblastoma, the validity of […]

Comparison of PC and iPad administrations of the Cogstate Brief Battery in the Mayo Clinic Study of Aging: Assessing cross-modality equivalence of computerized neuropsychological tests.

Authors: Edwards KK, Knopman DS, Kremers WK, Lundt ES, Machulda MM, Mielke MM, Petersen RC, Roberts RO, Stricker NH

Journal: The Clinical Neuropsychologist

DOI: 10.1080/13854046.2018.1519085

Year Published: 2019

Objective: Computerized neuropsychological assessments are increasingly used in clinical practice, population studies of cognitive aging and clinical trial enrichment. Subtle, but significant, performance differences have been demonstrated across different modes of test administration and require further investigation. Method: Participants included cognitively unimpaired adults aged 50 and older from the Mayo Clinic Study of Aging who […]

Neuropsychological benefits of computerized cognitive rehabilitation training in Ugandan children surviving severe malaria: A randomized controlled trial.

Authors: Boivin MJ, Familiar-Lopez I, Giordani B, Nakasujja N, Opoka RO, Ruiseñor-Escudero H, Sikorskii A, van der Lugt EM, Walhof K

Journal: Brain Research Bulletin

DOI: 10.1016/j.brainresbull.2018.03.002

Year Published: 2018

BACKGROUND: Computerized cognitive rehabilitation training (CCRT) may be beneficial for alleviating persisting neurocognitive deficits in Ugandan severe malaria survivors. We completed a randomized controlled trial of CCRT for both severe malaria and non-malaria cohorts of children. METHODS: 150 school-age severe malaria and 150 non-malaria children were randomized to three treatment arms: 24 sessions of Captain’s […]

Episodic Memory and Learning Dysfunction Over an 18-Month Period in Preclinical and Prodromal Alzheimer’s Disease.

Authors: Ames D, Baker JE, Jaeger J, Lautenschlager NT, Lim YY, Maruff P, Masters CL, Pietrzak RH, Robertson J, Rowe CC, Snyder PJ, Villemagne VL

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-180344

Year Published: 2018

Recent meta-analyses suggest that episodic memory impairment associated with preclinical Alzheimer’s disease (AD) equates to 0.15-0.24 standard deviations below that of cognitively healthy older adults. The current study aimed to characterize impairments in verbal acquisition and recall detectable at a single assessment, and investigate how verbal learning and episodic memory deteriorates in preclinical AD. A […]

Computerized Cognitive Testing for Use in Clinical Trials: A Comparison of the NIH Toolbox and Cogstate C3 Batteries.

Authors: Buckley RF, Burnham S, Dekhtyar M, Martin C, Papp KV, Rentz DM, Sparks KP, Sperling RA

Journal: The Journal of Prevention of Alzheimer's Disease

DOI: 10.14283/jpad.2017.1.

Year Published: 2018

BACKGROUND As prevention trials for Alzheimer’s disease move into asymptomatic populations, identifying older individuals who manifest the earliest cognitive signs of Alzheimer’s disease is critical. Computerized cognitive testing has the potential to replace current gold standard paper and pencil measures and may be a more efficient means of assessing cognition. However, more empirical evidence about […]

Effects of Recent Alcohol Consumption Level on Neurocognitive Performance in HIV+ Individuals.

Authors: Douglas-Newman KR, Kranzler HR, Pond T, Smith RV, Spiers MV

Journal: Addictive Disorders & their Treatment

DOI: 10.1097/ADT.0000000000000109

Year Published: 2017

OBJECTIVES: Although HIV+ individuals may be at increased risk of alcohol-related cognitive impairment, the relations between drinking level and cognitive performance in these individuals are not well understood. We examined whether higher levels of recent drinking in HIV+ individuals were associated with poorer cognitive performance, particularly in executive functioning (EF) and memory. METHODS: We administered […]

Determining optimal impairment rating methodology for a new HIV-associated neurocognitive disorder screening procedure.

Authors: Bloch M, Brew BJ, Carberry A, Cysique LA, Kamminga J, Vincent T

Journal: Journal of Clinical and Experimental Neuropsychology

DOI: 10.1080/13803395.2016.1263282

Year Published: 2017

INTRODUCTION: The current study sought to determine the optimal impairment rating definition for a new HIV-associated neurocognitive disorder (HAND) screening procedure as compared to standard neuropsychological testing. METHOD: A total of 55 HIV-infected (HIV+; 19% AIDS; 87% on combination antiretroviral therapy, cART; 80% plasma undetectable) and 22 demographically comparable HIV-uninfected (HIV-) control adults (all male) […]

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Relation between retinal vascular abnormalities and working memory impairment in patients with schizophrenia and bipolar disorder.

Authors: Appaji A, Berendschot TTJM, Chako DM, Hiremath CV, Jacob A, Kesavan M, Nagendra B, Padmanabha A, Rao NP, Rao SV, Varambally S, Venkatasubramanian G, Webers CAB

Journal: Asian journal of psychiatry

DOI: 10.1016/j.ajp.2020.101942

Year Published: 2020

Emerging evidence indicates abnormal retinal micro-vasculature in schizophrenia (SCZ) and bipolar disorder (BD) and its relation to cognitive functions. However, the association of these abnormalities with the cognitive deficits in these disorders has not been examined till date. Hence, we explored this aspect in patients with SCZ, BD, and healthy volunteers (HV). We examined 34 […]

Decreased working memory capacity among individuals with a mood disorder who have increased metabolic burden.

Authors: Babu P, Easter RE, Lamping E, Langenecker SA, Marshall DF, McInnis MG, Peterman JS, Ryan KA

Journal: Journal of Affective Disorders

DOI: 10.1016/j.jad.2020.01.073

Year Published: 2020

BACKGROUND: Individuals with mood disorders experience a higher rate of obesity than the general population, putting them at risk for poorer outcomes. The relationship between obesity and a core feature of the mood disorders, neurocognition, is less understood. We examined the interaction of obesity as indexed by body mass index (BMI) and working memory performance […]

Computerised cognitive training to improve cognition including delirium following coronary artery bypass grafting surgery: protocol for a blinded randomised controlled trial.

Authors: Bourke A, Davis DHJ, Greaves D, Keage HAD, Lampit A, Psaltis PJ, Smith AE, Valenzuela MJ, Worthington MG

Journal: BMJ Open

DOI: 10.1136/bmjopen-2019-034551

Year Published: 2020

INTRODUCTION: Coronary artery bypass grafting (CABG) surgery is known to improve vascular function and cardiac-related mortality rates; however, it is associated with high rates of postoperative cognitive decline and delirium. Previous attempts to prevent post-CABG cognitive decline using pharmacological and surgical approaches have been largely unsuccessful. Cognitive prehabilitation and rehabilitation are a viable yet untested […]

Longitudinal Comparison of in Clinic and at Home Administration of the Cogstate Brief Battery and Demonstrated Practice Effects in the Mayo Clinic Study of Aging.

Authors: Albertson SM, Alden EC, Knopman DS, Kremers WK, Lundt ES, Machulda MM, Mielke MM, Petersen RC, Stricker NH

Journal: The Journal of Prevention of Alzheimer's Disease

DOI: 10.14283/jpad.2019.35

Year Published: 2020

BACKGROUND: The Cogstate Brief Battery (CBB) is a computerized cognitive assessment that can be completed in clinic or at home. Design/Objective: This retrospective study investigated whether practice effects / performance trajectories of the CBB differ by location of administration. PARTICIPANTS/SETTING: Participants included 1439 cognitively unimpaired individuals age 50-75 at baseline participating in the Mayo Clinic […]

A fair comparison of tree-based and parametric methods in multiple imputation by chained equations.

Authors: Naylor MG, Slade E

Journal: Statistics in medicine

DOI: 10.1002/sim.8468

Year Published: 2020

Multiple imputation by chained equations (MICE) has emerged as a leading strategy for imputing missing epidemiological data due to its ease of implementation and ability to maintain unbiased effect estimates and valid inference. Within the MICE algorithm, imputation can be performed using a variety of parametric or nonparametric methods. Literature has suggested that nonparametric tree-based […]

Use of an experimental language acquisition paradigm for standardized neuropsychological assessment of learning: A pilot study in young and older adults.

Authors: Baker JE, Bruns L Jr, Hassenstab J, Lim YY, Maruff P, Masters CL

Journal: Journal of Clinical and Experimental Neuropsychology

DOI: 10.1080/13803395.2019.1665626

Year Published: 2020

Introduction: Despite the numerous episodic memory tasks used in neuropsychological assessment, relatively few learning tasks are available, with methods lacking the complexity and sophistication to capture very subtle changes in information acquisition. Method: We adapted a previously validated associative learning task for use within an online framework, utilizing real-world stimuli, in which learning of audio-visual […]

Hippocampal segmentation for brains with extensive atrophy using three-dimensional convolutional neural networks.

Authors: Adamo S, Akhavein H, Black SE, Gao F, Goubran M, Holmes M, MacIntosh B, Martel A, Masellis M, Nestor S, Ntiri EE, Ozzoude M, Ramirez J, Scott C, Swardfager W, Swartz R

Journal: Human brain mapping

DOI: 10.1002/hbm.24811

Year Published: 2020

Hippocampal volumetry is a critical biomarker of aging and dementia, and it is widely used as a predictor of cognitive performance; however, automated hippocampal segmentation methods are limited because the algorithms are (a) not publicly available, (b) subject to error with significant brain atrophy, cerebrovascular disease and lesions, and/or (c) computationally expensive or require parameter […]

Identification of Pre-Clinical Alzheimer’s Disease in a Population of Elderly Cognitively Normal Participants.

Authors: Doecke JD, Maruff P, Mengersen K, Rousseau J, van Havre Z, Villemagne VL, White N

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191095

Year Published: 2020

Alzheimer’s disease (AD) has a long pathological process, with an approximate lead-time of 20 years. During the early stages of the disease process, little evidence of the building pathology is identifiable without cerebrospinal fluid and/or imaging analyses. Clinical manifestations of AD do not present until irreversible pathological changes have occurred. Given an opportunity to provide […]

The Effect of Hearing Aid Use on Cognition in Older Adults: Can We Delay Decline or Even Improve Cognitive Function?

Authors: Busby P, Harris D, Launer S, Lemke U, Maruff P, Sarant J, Schembri A

Journal: Journal of clinical medicine

DOI: 10.3390/jcm9010254

Year Published: 2020

Hearing loss is a modifiable risk factor for dementia in older adults. Whether hearing aid use can delay the onset of cognitive decline is unknown. Participants in this study (aged 62-82 years) were assessed before and 18 months after hearing aid fitting on hearing, cognitive function, speech perception, quality of life, physical activity, loneliness, isolation, […]

Associations of Apolipoprotein E ε4 Genotype and Ball Heading With Verbal Memory in Amateur Soccer Players.

Authors: Davies P, Freudenberg-Hua Y, Hu S, Hunter LE, Kim M, Lipton ML, Lipton RB, Srinivasan P, Stewart WF

Journal: JAMA Neurology

DOI: 10.1001/jamaneurol.2019.4828

Year Published: 2020

Importance: Emerging evidence suggests that long-term exposure to ball heading in soccer, the most popular sport in the world, confers risk for adverse cognitive outcomes. However, the extent to which the apolipoprotein E ε4 (APOE ε4) allele, a common risk factor for neurodegeneration, and ball heading are associated with cognition in soccer players remains unknown. […]

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Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance.

Authors: Ames D, Dang C, Doecke JD, Fripp J, Harrington KD, Hickey M, Laws SM, Lim YY, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Salvado O, Snyder PJ, Sohrabi HR, Villemagne VL, Weinborn M, Xia Y, Yassi N

Journal: Alzheimer's & dementia : diagnosis assessment & disease monitoring

DOI: 10.1016/j.dadm.2019.05.005

Year Published: 2019

Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older […]

SuperAging: Current findings yield future challenges-A response to Rogalski and Goldberg.

Authors: Dang C, Maruff P

Journal: Alzheimer's & dementia : diagnosis assessment & disease monitoring

DOI: 10.1016/j.dadm.2019.05.004

Year Published: 2019

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Influence of Comorbidity of Cerebrovascular Disease and Amyloid-β on Alzheimer’s Disease.

Authors: Ames D, Chen C, Desmond PM, Fowler C, Hilal S, Kuijf H, Lim YY, Martins R, Maruff P, Masters CL, Rowe C, Salvado O, Villemagne V, Watson R, Xia Y, Yassi N, Yates P

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191028

Year Published: 2019

BACKGROUND: Quantifying the contribution of cerebrovascular disease to the clinical and pathological profile of Alzheimer’s disease is challenging. OBJECTIVE: We aimed to determine the influence of cerebrovascular disease, amyloid-β (Aβ), and their comorbidity on cognitive decline, hippocampal atrophy, and Aβ deposition, by evaluating data from the Australian Imaging, Biomarker and Lifestyle Study of Ageing. METHODS: […]

Identification of Pre-Clinical Alzheimer’s Disease in a Population of Elderly Cognitively Normal Participants.

Authors: Doecke JD, Maruff P, Mengersen K, Rousseau J, van Havre Z, Villemagne V, White N

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191095

Year Published: 2019

Alzheimer’s disease (AD) has a long pathological process, with an approximate lead-time of 20 years. During the early stages of the disease process, little evidence of the building pathology is identifiable without cerebrospinal fluid and/or imaging analyses. Clinical manifestations of AD do not present until irreversible pathological changes have occurred. Given an opportunity to provide […]

C-reactive protein and response to lurasidone treatment in children and adolescents with bipolar I depression: Results from a placebo-controlled trial.

Authors: Loebel A, Pikalov A, Raison CL, Siu C, Tocco M

Journal: Brain behavior and immunity

DOI: 10.1016/j.bbi.2019.12.010

Year Published: 2019

This study sought to investigate associations between levels of high-sensitivity c-reactive protein (hsCRP) prior to treatment and change in depressive symptoms and cognition in a short-term, double-blind, placebo-controlled study of lurasidone in children and adolescents with bipolar I depression. Patients 10-17 years of age with a DSM-5 diagnosis of bipolar I depression were randomized to […]

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