Access hundreds of peer-reviewed cognitive research papers published by leading neuroscientists using Cogstate technology.



Neuropsychological benefits of computerized cognitive rehabilitation training in Ugandan children surviving severe malaria: A randomized controlled trial.

Authors: Boivin MJ, Familiar-Lopez I, Giordani B, Nakasujja N, Opoka RO, Ruiseñor-Escudero H, Sikorskii A, van der Lugt EM, Walhof K

Journal: Brain Research Bulletin

DOI: 10.1016/j.brainresbull.2018.03.002

Year Published: 2018

BACKGROUND: Computerized cognitive rehabilitation training (CCRT) may be beneficial for alleviating persisting neurocognitive deficits in Ugandan severe malaria survivors. We completed a randomized controlled trial of CCRT for both severe malaria and non-malaria cohorts of children. METHODS: 150 school-age severe malaria and 150 non-malaria children were randomized to three treatment arms: 24 sessions of Captain’s […]

Computerized Cognitive Testing for Use in Clinical Trials: A Comparison of the NIH Toolbox and Cogstate C3 Batteries.

Authors: Buckley RF, Burnham S, Dekhtyar M, Martin C, Papp KV, Rentz DM, Sparks KP, Sperling RA

Journal: The Journal of Prevention of Alzheimer's Disease

Volume & Issue: 4 & 1

Page No.: 3-11

DOI: 10.14283/jpad.2017.1.

Year Published: 2018

BACKGROUND As prevention trials for Alzheimer’s disease move into asymptomatic populations, identifying older individuals who manifest the earliest cognitive signs of Alzheimer’s disease is critical. Computerized cognitive testing has the potential to replace current gold standard paper and pencil measures and may be a more efficient means of assessing cognition. However, more empirical evidence about […]

Prevalence of cognitive impairment in major depression and bipolar disorder

Authors: Allan H Young, Christopher MA Frampton, I Nicol Ferrier, Janet D Carter, Katie M Douglas, Lucy J Robinson, Peter Gallagher, Richard J Porter, Stuart Watson, Virginia VW McIntosh

Journal: Bipolar Disorders

DOI: 10.1111/bdi.12602

Year Published: 2018

Objectives: The current study examines prevalence of cognitive impairment in four mood disorder samples, using four definitions of impairment. The impact of premorbid IQ on prevalence was examined, and the influence of treatment response. Methods: Samples were: (i) 58 inpatients in a current severe depressive episode (unipolar or bipolar), (ii) 69 unmedicated outpatients in a […]

Effects of Recent Alcohol Consumption Level on Neurocognitive Performance in HIV+ Individuals.

Authors: Douglas-Newman KR, Kranzler HR, Pond T, Smith RV, Spiers MV

Journal: Addictive Disorders & their Treatment

Volume & Issue: 16 & 3

Page No.: 95-107

DOI: 10.1097/ADT.0000000000000109

Year Published: 2017

OBJECTIVES: Although HIV+ individuals may be at increased risk of alcohol-related cognitive impairment, the relations between drinking level and cognitive performance in these individuals are not well understood. We examined whether higher levels of recent drinking in HIV+ individuals were associated with poorer cognitive performance, particularly in executive functioning (EF) and memory. METHODS: We administered […]

Determining optimal impairment rating methodology for a new HIV-associated neurocognitive disorder screening procedure.

Authors: Bloch M, Brew BJ, Carberry A, Cysique LA, Kamminga J, Vincent T

Journal: Journal of Clinical and Experimental Neuropsychology

Page No.: 1-15

DOI: 10.1080/13803395.2016.1263282

Year Published: 2017

INTRODUCTION: The current study sought to determine the optimal impairment rating definition for a new HIV-associated neurocognitive disorder (HAND) screening procedure as compared to standard neuropsychological testing. METHOD: A total of 55 HIV-infected (HIV+; 19% AIDS; 87% on combination antiretroviral therapy, cART; 80% plasma undetectable) and 22 demographically comparable HIV-uninfected (HIV-) control adults (all male) […]

Neuropsychological Impairment and Its Association with Violence Risk in Japanese Forensic Psychiatric Patients: A Case-Control Study.

Authors: Hashimoto K, Hirabayashi N, Igarashi Y, Imai A, Kuroda O, Kuroki N, Nagata T, Nakane J, Nishinaka H, Omori M, Sakikawa N

Journal: Public Library of Science One

DOI: 10.1371/journal.pone.0148354

Year Published: 2016

BACKGROUND: In Japan, the legislation directing treatment of offenders with psychiatric disorders was enacted in 2005. Neuropsychological impairment is highly related to functional outcomes in patients with psychiatric disorders, and several studies have suggested an association between neuropsychological impairment and violent behaviors. However, there have been no studies of neuropsychological impairment in forensic patients covered […]

The nature and rate of cognitive maturation from late childhood to adulthood.

Authors: Cromer JA, Harel BT, Maruff P, Schembri AJ

Journal: Frontiers in Psychology

DOI: 10.3389/fpsyg.2015.00704

Year Published: 2015

To better understand the nature and rate of cognitive change across adolescence, the Cogstate Brief Battery (CBB) was utilized to assess psychomotor function, attention, working memory, and visual learning in individuals aged 10-18 years old. Since all CBB tasks have equivalent perceptual, motor, and linguistic demands as well as being appropriate for both children and […]

Performance of the CogState computerized battery in the Mayo Clinic Study on Aging

Authors: Edwards KK, Hagen CE, Jack CR, Knopman DS, Machulda MM, Mielke MM, Pankratz VS, Petersen RC, Roberts RO

Journal: Alzheimer's and Dementia

DOI: 10.1016/j.jalz.2015.01.008

Year Published: 2015

BACKGROUND: The feasibility and validity of brief computerized cognitive batteries at the population-level are unknown. METHODS: Nondemented participants (n = 1660, age 50-97 years) in the Mayo Clinic Study on Aging completed the computerized CogState battery and standard neuropsychological battery. The correlation between tests was examined and comparisons between CogState performance on the personal computer (PC) and […]

Neuropsychological problems and alcohol availability appear to be key factors in continued heavy alcohol use by Aboriginal Australians.

Authors: Cairney S, Dingwall KM, Maruff P

Journal: The Medical Journal of Australia

Volume & Issue: 194 & 1

Page No.: 50-1

Year Published: 2011

The importance of cognition to quality of life after stroke.

Authors: Bernhardt J, Brodtmann A, Cumming TB, Darby D

Journal: Journal of Psychosomatic Research

Volume & Issue: pii: S0022-3999 & 14

DOI: 10.1016/j.jpsychores.2014.08.009

Year Published: 2014

OBJECTIVE: Suffering a stroke typically has a negative impact on a person’s quality of life. There is some evidence that post-stroke cognitive impairment is associated with poor quality of life, but the relative importance of deficits in different cognitive domains has not been established. METHODS: Patients with confirmed stroke were recruited in the acute hospital. […]

Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment.

Authors: Bondi MW, Delano-Wood L, Edmonds EC, Galasko DR, Salmon DP

Journal: Journal of the International Neuropsychological Society

Volume & Issue: 20 & 8

Page No.: 836-47

DOI: 10.1017/S135561771400068X

Year Published: 2014

Subjective cognitive complaints are a criterion for the diagnosis of mild cognitive impairment (MCI), despite their uncertain relationship to objective memory performance in MCI. We aimed to examine self-reported cognitive complaints in subgroups of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) MCI cohort to determine whether they are a valuable inclusion in the diagnosis of MCI […]

An analysis of systems of classifying mild cognitive impairment in older people.

Authors: Collie A, Maruff P

Journal: The Australian and New Zealand Journal of Psychiatry

Volume & Issue: 36 & 1

Page No.: 133-40

DOI: 10.1046/j.1440-1614.2002.00972.x

Year Published: 2002

OBJECTIVE: Over the past two decades, a number of systems have been developed for the classification of cognitive and behavioural abnormalities in older people, in order that individuals at high risk of developing neurodegenerative disease, particularly Alzheimer’s disease, may be identified well before the disease manifests clinically. This article critically examines the inclusion and exclusion […]

The cognitive neuropsychiatric approach to investigating the neurobiology of schizophrenia and other disorders.

Authors: Maruff P, Pantelis C

Journal: Journal of Psychosomatic Research

Volume & Issue: 53 & 2

Page No.: 655-64

Year Published: 2002

In this paper, we examine a cognitive neuropsychiatric approach to understanding neuropsychiatric disorders by examining recent data in schizophrenia. By understanding and applying this approach, we suggest that the processes underlying the neurobiology of a range of other psychiatric disorders can be understood. Further, an assessment of the brain-behaviour relationships through this emerging discipline provides […]

Cognitive effects of immediate-release methylphenidate in children with attention-deficit/hyperactivity disorder.

Authors: Maruff P, Mollica CM, Pietrzak RH, Snyder PJ

Journal: Neuroscience and Biobehavioral Reviews

Volume & Issue: 30 & 8

Page No.: 1225-45

DOI: 10.1016/j.neubiorev.2006.10.002

Year Published: 2006

A growing body of literature has examined the cognitive effects of immediate-release methylphenidate in children with attention-deficit/hyperactivity disorder (ADHD). However, a clear understanding of the types and magnitude of such effects are difficult to discern from such a large and varied collection of published reports. This review evaluated a total of 40 relevant placebo-controlled studies […]

Neuropsychological functioning in bipolar disorder and schizophrenia.

Authors: Cascella NG, Diaz-Asper CM, Dickerson FB, Kingery LR, Meyer SM, Munro CA, Pearlson GD, Pulver AE, Rao VA, Rivkin P, Schretlen DJ, Testa SM, Yolken RH

Journal: Biological Psychiatry

Volume & Issue: 62 & 2

Page No.: 179-86

Year Published: 2007

BACKGROUND: Some patients with bipolar disorder (BD) demonstrate neuropsychological deficits even when stable. However, it remains unclear whether these differ qualitatively from those seen in schizophrenia (SZ). METHODS: We compared the nature and severity of cognitive deficits shown by 106 patients with SZ and 66 patients with BD to 316 healthy adults (NC). All participants […]

1 2