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Access hundreds of peer-reviewed cognitive research papers published by leading neuroscientists using Cogstate technology.

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Preliminary exploration of a computerized cognitive battery and comparison with traditional testing in patients with high-grade glioma.

Authors: Anderson SK, Brown PD, Caine C, Cerhan JH, Johnson DR, Lachance DH, Yan E

Journal: Neuro-oncology practice

DOI: 10.1093/nop/npy013

Year Published: 2019

Background: Cognitive function is an important outcome measure in many brain tumor clinical trials, and investigators are interested in employing the most efficient methods of cognitive assessment for this purpose. Computerized testing can be appealing because of the perceived ease of use and electronic data generated. Traditional tests may have the advantage of accumulated validity […]

The feasibility, reliability and concurrent validity of the MSReactor computerized cognitive screening tool in multiple sclerosis.

Authors: Butzkueven H, Darby D, Kalincik T, Merlo D, Van der Walt A

Journal: Therapeutic advances in neurological disorders

DOI: 10.1177/1756286419859183

Year Published: 2019

Background: Multiple sclerosis (MS) cognitive tests are resource intensive and limited by practice effects that prevent frequent retesting. Brief, reliable and valid monitoring tools are urgently needed to detect subtle, subclinical cognitive changes in people with MS. Cognitive monitoring over time could contribute to a new definition of disease progression, supplementing routine clinical monitoring. Methods: […]

Computerized assessment of cognitive impairment among children undergoing radiation therapy for medulloblastoma.

Authors: Ashford JM, Conklin HM, Gajjar A, Harel BT, Heitzer AM, Merchant TE, Ness KK, Robinson GW, Schembri A, Swain MA, Wallace J, Wang F, Zhang H

Journal: Journal of Neuro-oncology

DOI: 10.1007/s11060-018-03046-2

Year Published: 2019

PURPOSE: Advantages to computerized cognitive assessment include increased precision of response time measurement and greater availability of alternate forms. Cogstate is a computerized cognitive battery developed to monitor attention, memory, and processing speed. Although the literature suggests the domains assessed by Cogstate are areas of deficit in children undergoing treatment for medulloblastoma, the validity of […]

Comparison of PC and iPad administrations of the Cogstate Brief Battery in the Mayo Clinic Study of Aging: Assessing cross-modality equivalence of computerized neuropsychological tests.

Authors: Edwards KK, Knopman DS, Kremers WK, Lundt ES, Machulda MM, Mielke MM, Petersen RC, Roberts RO, Stricker NH

Journal: The Clinical Neuropsychologist

DOI: 10.1080/13854046.2018.1519085

Year Published: 2019

Objective: Computerized neuropsychological assessments are increasingly used in clinical practice, population studies of cognitive aging and clinical trial enrichment. Subtle, but significant, performance differences have been demonstrated across different modes of test administration and require further investigation. Method: Participants included cognitively unimpaired adults aged 50 and older from the Mayo Clinic Study of Aging who […]

Neuropsychological benefits of computerized cognitive rehabilitation training in Ugandan children surviving severe malaria: A randomized controlled trial.

Authors: Boivin MJ, Familiar-Lopez I, Giordani B, Nakasujja N, Opoka RO, Ruiseñor-Escudero H, Sikorskii A, van der Lugt EM, Walhof K

Journal: Brain Research Bulletin

DOI: 10.1016/j.brainresbull.2018.03.002

Year Published: 2018

BACKGROUND: Computerized cognitive rehabilitation training (CCRT) may be beneficial for alleviating persisting neurocognitive deficits in Ugandan severe malaria survivors. We completed a randomized controlled trial of CCRT for both severe malaria and non-malaria cohorts of children. METHODS: 150 school-age severe malaria and 150 non-malaria children were randomized to three treatment arms: 24 sessions of Captain’s […]

Episodic Memory and Learning Dysfunction Over an 18-Month Period in Preclinical and Prodromal Alzheimer’s Disease.

Authors: Ames D, Baker JE, Jaeger J, Lautenschlager NT, Lim YY, Maruff P, Masters CL, Pietrzak RH, Robertson J, Rowe CC, Snyder PJ, Villemagne VL

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-180344

Year Published: 2018

Recent meta-analyses suggest that episodic memory impairment associated with preclinical Alzheimer’s disease (AD) equates to 0.15-0.24 standard deviations below that of cognitively healthy older adults. The current study aimed to characterize impairments in verbal acquisition and recall detectable at a single assessment, and investigate how verbal learning and episodic memory deteriorates in preclinical AD. A […]

Computerized Cognitive Testing for Use in Clinical Trials: A Comparison of the NIH Toolbox and Cogstate C3 Batteries.

Authors: Buckley RF, Burnham S, Dekhtyar M, Martin C, Papp KV, Rentz DM, Sparks KP, Sperling RA

Journal: The Journal of Prevention of Alzheimer's Disease

DOI: 10.14283/jpad.2017.1.

Year Published: 2018

BACKGROUND As prevention trials for Alzheimer’s disease move into asymptomatic populations, identifying older individuals who manifest the earliest cognitive signs of Alzheimer’s disease is critical. Computerized cognitive testing has the potential to replace current gold standard paper and pencil measures and may be a more efficient means of assessing cognition. However, more empirical evidence about […]

Effects of Recent Alcohol Consumption Level on Neurocognitive Performance in HIV+ Individuals.

Authors: Douglas-Newman KR, Kranzler HR, Pond T, Smith RV, Spiers MV

Journal: Addictive Disorders & their Treatment

DOI: 10.1097/ADT.0000000000000109

Year Published: 2017

OBJECTIVES: Although HIV+ individuals may be at increased risk of alcohol-related cognitive impairment, the relations between drinking level and cognitive performance in these individuals are not well understood. We examined whether higher levels of recent drinking in HIV+ individuals were associated with poorer cognitive performance, particularly in executive functioning (EF) and memory. METHODS: We administered […]

Determining optimal impairment rating methodology for a new HIV-associated neurocognitive disorder screening procedure.

Authors: Bloch M, Brew BJ, Carberry A, Cysique LA, Kamminga J, Vincent T

Journal: Journal of Clinical and Experimental Neuropsychology

DOI: 10.1080/13803395.2016.1263282

Year Published: 2017

INTRODUCTION: The current study sought to determine the optimal impairment rating definition for a new HIV-associated neurocognitive disorder (HAND) screening procedure as compared to standard neuropsychological testing. METHOD: A total of 55 HIV-infected (HIV+; 19% AIDS; 87% on combination antiretroviral therapy, cART; 80% plasma undetectable) and 22 demographically comparable HIV-uninfected (HIV-) control adults (all male) […]

Neuropsychological Impairment and Its Association with Violence Risk in Japanese Forensic Psychiatric Patients: A Case-Control Study.

Authors: Hashimoto K, Hirabayashi N, Igarashi Y, Imai A, Kuroda O, Kuroki N, Nagata T, Nakane J, Nishinaka H, Omori M, Sakikawa N

Journal: Public Library of Science One

DOI: 10.1371/journal.pone.0148354

Year Published: 2016

BACKGROUND: In Japan, the legislation directing treatment of offenders with psychiatric disorders was enacted in 2005. Neuropsychological impairment is highly related to functional outcomes in patients with psychiatric disorders, and several studies have suggested an association between neuropsychological impairment and violent behaviors. However, there have been no studies of neuropsychological impairment in forensic patients covered […]

The nature and rate of cognitive maturation from late childhood to adulthood.

Authors: Cromer JA, Harel BT, Maruff P, Schembri AJ

Journal: Frontiers in Psychology

DOI: 10.3389/fpsyg.2015.00704

Year Published: 2015

To better understand the nature and rate of cognitive change across adolescence, the Cogstate Brief Battery (CBB) was utilized to assess psychomotor function, attention, working memory, and visual learning in individuals aged 10-18 years old. Since all CBB tasks have equivalent perceptual, motor, and linguistic demands as well as being appropriate for both children and […]

Reliability of repeated cognitive assessment of dementia using a brief computerized battery.

Authors: Albin R, Barbas N, Darby D, Frey K, Giordani B, Hammers D, Heidebrink J, Persad C, Ryan K, Spurgeon E

Journal: American Journal of Alzheimer's Disease and Other Dementias

DOI: 10.1177/1533317511411907

Year Published: 2011

OBJECTIVE: The aim of this study was to evaluate the short-term stability and reliability of a brief computerized cognitive battery in established dementia types. METHOD: Patients were administered the computerized battery twice with administrations approximately 2 hours apart, with intervening conventional neuropsychological tests. Patients were classified clinically, via consensus conference, as healthy controls (n = […]

Cutting a long story short: reaction times in acute stroke are associated with longer term cognitive outcomes.

Authors: Bernhardt J, Brodtmann A, Cumming TB, Darby D

Journal: Journal of the Neurological Sciences

DOI: 10.1016/j.jns.2012.07.004

Year Published: 2012

BACKGROUND: The viability and usefulness of cognitive assessment in acute stroke have been questioned, with practical challenges arising from the focal nature of neurological deficits as well as heterogeneity in arousal state. We aimed to test whether acute measures of attention correlate with attentional function at 3 months post-stroke. METHODS: Patients with confirmed stroke completed […]