Comparison of cognitive functioning as measured by the Ruff Figural Fluency Test and the CogState computerized battery within the LifeLines Cohort Study.
BACKGROUND: The Ruff Figural Fluency Test (RFFT; a pencil and paper test) and the CogState (a computerized cognitive test battery) are well-validated and suitable tests to evaluate cognitive functioning in large observational studies at the population level. The LifeLines Cohort Study includes the RFFT as baseline measurement and incorporated the CogState as replacement for the […]
BACKGROUND: Assessment of risk and early diagnosis of Alzheimer’s disease (AD) is a key to its prevention or slowing the progression of the disease. Previous research on risk factors for AD typically utilizes statistical comparison tests or stepwise selection with regression models. Outcomes of these methods tend to emphasize single risk factors rather than a […]
Detection of postoperative cognitive decline after coronary artery bypass graft surgery is affected by the number of neuropsychological tests in the assessment battery.
BACKGROUND: The assessment of postoperative cognitive dysfunction after coronary artery bypass graft surgery is made with the repeated administration of cognitive tests. This classification is vulnerable to error, and it has been suggested that increasing the number of tests in a battery while maintaining constant inclusion criteria for postoperative cognitive dysfunction increases the rate of […]
Disability in life functioning is an important and poorly understood consequence of major depressive disorder (MDD). Mood symptoms do not account for the magnitude of disability resulting from MDD. Impairments in several domains of neurocognitive (NC) functioning have been shown to interfere with functionality in other psychiatric populations. These deficits, also present in MDD, may […]
Neurocognitive test performance predicts functional recovery from acute exacerbation leading to hospitalization in bipolar disorder.
OBJECTIVE: Bipolar disorder (BPD) is associated with significant functional morbidity at a rate which is particularly elevated among patients discharged from hospital. The aim of this study was to examine the degree to which neurocognitive test performance, measured following hospitalization for an acute affective episode, is predictive of functional recovery 1 year later. METHODS: Seventy-eight […]
OBJECTIVE: Our objective was to determine whether minor head trauma in elite soccer matches causes measurable impairment in brain function. METHODS: Baseline neuropsychological testing was completed by professional soccer players in the Norwegian elite league, Tippeligaen, before the 2004 and 2005 seasons (n = 462). A player who experienced a head impact during a league […]
Pilot evaluation of a novel clinical test of reaction time in national collegiate athletic association division I football players.
CONTEXT: Evidence suggests that concussion prolongs reaction time (RT). We have developed a simple, reliable clinical tool for measuring reaction time that may be of value in the assessment of concussion in athletes. OBJECTIVE: To compare baseline values of clinical RT (RT(clin)) obtained using the new clinical reaction time apparatus with computerized RT (RT(comp)) obtained […]
BACKGROUND: The self-care regimen necessary in heart failure (HF) is notably complex. A complication to integrating new knowledge and behaviors is that impaired cognition has been frequently reported in patients with HF, which significantly impacts patients’ health, admission and mortality rates, and instrumental activities of daily living. OBJECTIVE: The identification of reliable cognitive screening tools […]
Three-month stability of the CogState brief battery in healthy older adults, mild cognitive impairment, and Alzheimer’s disease: results from the Australian Imaging, Biomarkers, and Lifestyle-rate of change substudy (AIBL-ROCS).
Large prospective studies of Alzheimer’s disease (AD) have sought to understand the pathological evolution of AD and factors that may influence the rate of disease progression. Estimates of rates of cognitive change are available for 12 or 24 months, but not for shorter time frames (e.g., 3 or 6 months). Most clinical drug trials seeking […]
Minimal Cognitive Impairment in UK HIV Positive Men Who Have Sex with Men: Effect of Case Definitions, and Comparison with the General Population and HIV Negative Men
BACKGROUND To determine the prevalence of neurocognitive impairment (NCI) in UK HIV positive and HIV negative men who have sex with men (MSM). METHODS HIV positive (HIV+) and negative participants were recruited to a cross-sectional study from two London clinics and completed computer-assisted neuropsychological tests and questionnaires of depression, anxiety and activities of daily living. […]