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Phase 2 Trial of an Alpha-7 Nicotinic Receptor Agonist (TC-5619) in Negative and Cognitive Symptoms of Schizophrenia.

Authors: Beaver JS, Dunbar GC, Dvergsten C, Fleischhacker WW, Hosford DA, Jett JE, Kane J, Keefe RS, Marder SR, Segreti AC, Toler SM, Walling D

Journal: Schizophrenia Bulletin

Year Published: 2015

OBJECTIVES: This trial was conducted to test the effects of an alpha7 nicotinic receptor full agonist, TC-5619, on negative and cognitive symptoms in subjects with schizophrenia. METHODS: In 64 sites in the United States, Russia, Ukraine, Hungary, Romania, and Serbia, 477 outpatients (18-65 years; male 62%; 55% tobacco users) with schizophrenia, treated with a new-generation […]