multiple sclerosis

Moving intra-individual variability (IIV) towards clinical utility: IIV measured using a commercial testing platform

Authors: Hyein Cho, Giuseppina Pilloni, Raisa Tahsin, Pamela Best, Lauren Krupp, Cheongeun Oh, Leigh Charvet

Journal: Journal of the Neurological Sciences

Year Published: 2023

Objectives: Intra-individual variability (IIV), measured across repeated response times (RT) during continuous psychomotor tasks, is an early marker of cognitive change in the context of neurodegeneration. To advance IIV towards broader application in clinical research, we […]

Early neuropsychological markers of cognitive involvement in multiple sclerosis

Authors: Tehila Eilam-Stock, Michael T Shaw, Lauren B Krupp, Leigh E Charvet

Journal: Journal of Neurological Sciences

Year Published: 2021

Background Cognitive impairment due to multiple sclerosis (MS) is common and often limits occupational functioning, contributes to disability, and reduces quality of life. Early detection of cognitive involvement in MS is critical for treatment planning and […]

Computerized neuropsychological assessment devices in multiple sclerosis: A systematic review

Authors: Curtis M Wojcik, Meghan Beier, Kathleen Costello, John DeLuca, Anthony Feinstein, Yael Goverover, Mark Gudesblatt, Michael Jaworski III, Rosalind Kalb, Lori Kostich, Nicholas G LaRocca, Jonathan D Rodgers, Ralph HB Benedict, National MS Society Cognition Work Team

Journal: Multiple Sclerosis: Clinical and Laboratory Research

Year Published: 2019

Background: The proliferation of computerized neuropsychological assessment devices (CNADs) for screening and monitoring cognitive impairment is increasing exponentially. Previous reviews of computerized tests for multiple sclerosis (MS) were primarily qualitative and did not rigorously compare CNADs […]

A Videogame-Based Digital Therapeutic to Improve Processing Speed in People with Multiple Sclerosis: A Feasibility Study

Authors: Riley M. Bove, Gillian Rush, Chao Zhao, William Rowles, Priya Garcha, John Morrissey, Adrian Schembri, Titi Alailima, Dawn Langdon, Katherine Possin, Adam Gazzaley, Anthony Feinstein & Joaquin Anguera

Journal: Neurology & Therapy

Year Published: 2019

Introduction: Self-administered in-home digital therapeutics could expand access to cognitive rehabilitation for individuals with multiple sclerosis (MS), over half of whom experience cognitive impairment (CI). However, feasibility in an MS population must be clarified. This study […]

Monitoring cognitive change in multiple sclerosis using a computerized cognitive battery

Authors: L De Meijer, D Merlo, O Skibina, E J Grobbee, J Gale, J Haartsen, P Maruff, D Darby, H Butzkueven, A Van der Walt

Journal: Multiple Sclerosis Journal - Experimental Translational and Clinical

Year Published: 2018

Background Cognitive monitoring that can detect short-term change in multiple sclerosis is challenging. Computerized cognitive batteries such as the CogState Brief Battery can rapidly assess commonly affected cognitive domains. Objectives The purpose of this study was […]

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