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Conversion Discriminative Analysis on Mild Cognitive Impairment Using Multiple Cortical Features from MR Images.

Authors: Cen G, Guo S, Lai C, Wu C

Journal: Frontiers in Aging Neuroscience

Volume & Issue: 9

Page No.: 146

DOI: 10.3389/fnagi.2017.00146

Year Published: 2017

Neuroimaging measurements derived from magnetic resonance imaging provide important information required for detecting changes related to the progression of mild cognitive impairment (MCI). Cortical features and changes play a crucial role in revealing unique anatomical patterns of brain regions, and further differentiate MCI patients from normal states. Four cortical features, namely, gray matter volume, cortical […]

Effect of APOE Genotype on Amyloid Deposition, Brain Volume, and Memory in Cognitively Normal Older Individuals.

Authors: Bourgeat P, Fowler C, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL, Williamson R

Journal: Journal of Alzheimer's Disease

Volume & Issue: 58 & 4

Page No.: 1293-1302

DOI: 10.3233/JAD-170072

Year Published: 2017

BACKGROUND: The association between the apolipoprotein E (APOE) ɛ4 allele and high risk of developing Alzheimer’s disease (AD) dementia before the age of 80 has been recognized for over 30 years. However, the timing and mode of action of APOE is not understood, nor has there been a detailed analysis of the effect of APOE […]

The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial.

Authors: Devenney KE, Lawlor B, Olde Rikkert MGM, Sanders ML, Schneider S

Journal: BMC Geriatrics

Volume & Issue: 17 & 1

Page No.: 75

DOI: 10.1186/s12877-017-0457-9

Year Published: 2017

BACKGROUND: Exercise interventions to prevent dementia and delay cognitive decline have gained considerable attention in recent years. Human and animal studies have demonstrated that regular physical activity targets brain function by increasing cognitive reserve. There is also evidence of structural changes caused by exercise in preventing or delaying the genesis of neurodegeneration. Although initial studies […]

Corrigendum: Corrigendum to ‘Self and informant memory concerns align in healthy memory complainers and in early stages of mild cognitive impairment but separate with increasing cognitive impairment’.

Authors: Ames D, Buckley R, Ellis K, Macaulay LS, Martins R, Maruff P, Masters C, Rainey-Smith S, Rembach A, Rowe C, Saling M, Savage G

Journal: Age and Ageing

Volume & Issue: 44 & 6

Page No.: 1012-9

DOI: 10.1093/ageing/afv136

Year Published: 2016

BACKGROUND: Information provided by an informant about a patient with cognitive change is an essential component of clinical history taking. How an informant’s report relates to the patient’s phenomenological experience of memory loss is yet to be understood. The aim was to examine patterns of relationships between self and informant reports from a phenomenological perspective. […]

Resting-State Cardiac Workload is Related to Both Increased Neocortical Aggregation of Amyloid-β and Relative Impairments in Spatial Working Memory in Pre-Clinical Alzheimer’s Disease.

Authors: Lim YY, Machan JT, Maruff P, Polynice S, Santos CY, Schindler R, Snyder PJ, Wu WC

Journal: Journal of Alzheimer's Disease

Year Published: 2015

We sought to determine whether there is any association between a cardiac workload marker, rate pressure product (RPP), working memory, and cortical amyloid-β (Aβ) burden in 63 cognitively normal midlife adults (Mage = 62.8 years; range = 55 to 75 years) at risk for Alzheimer’s disease (AD). The results show a small-to-moderate relationship between increasing cardiac workload (at rest) […]

Self and informant memory concerns align in healthy memory complainers and in early stages of mild cognitive impairment but separate with increasing cognitive impairment.

Authors: Ames D, Buckley R, Ellis K, Macaulay LS, Martins R, Maruff P, Masters C, Rainey-Smith S, Rembach A, Rowe C, Saling M, Savage G

Journal: Age and Ageing

Volume & Issue: 44 & 6

Page No.: 1012-9

DOI: 10.1093/ageing/afv136

Year Published: 2015

BACKGROUND: Information provided by an informant about a patient with cognitive change is an essential component of clinical history taking. How an informant’s report relates to the patient’s phenomenological experience of memory loss is yet to be understood. The aim was to examine patterns of relationships between self and informant reports from a phenomenological perspective. […]

Novel Statistically-Derived Composite Measures for Assessing the Efficacy of Disease-Modifying Therapies in Prodromal Alzheimer’s Disease Trials: An AIBL Study.

Authors: Ames D, Baker D, Burnham SC, Ellis K, Macaulay SL, Martins RN, Maruff P, Masters CL, Narayan VA, Novak G, Raghavan N, Romano G, Ropacki MT, Rowe CC, Savage G, Wilson W

Journal: Journal of Alzheimer's Disease

Volume & Issue: 46 & 4

Page No.: 1079-89

DOI: 10.3233/JAD-143015

Year Published: 2015

BACKGROUND: There is a growing consensus that disease-modifying therapies must be given at the prodromal or preclinical stages of Alzheimer’s disease (AD) to be effective. A major unmet need is to develop and validate sensitive measures to track disease progression in these populations. OBJECTIVE: To generate novel statistically-derived composites from standard scores, which have increased […]

Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures used Across 19 International Research Studies.

Authors: Amariglio RE, Berman LM, Boada M, Buckley RF, Chételat G, Crane PK, Dubois B, Ellis KA, Gifford KA, Jefferson AL, Jessen F, Katz MJ, Lipton RB, Luck T, Maruff P, Mielke MM, Molinuevo JL, Naeem F, Perrotin A, Petersen RC, Rabin LA, Rami L, Reisberg B, Rentz DM, Riedel-Heller SG, Risacher SL, Rodriguez O, Sachdev PS, Saykin AJ, Sikkes SA, Slavin MJ, Smart CM, Snitz BE, Sperling RA, Tandetnik C, van der Flier WM, Wagner M, Wolfsgruber S

Journal: Journal of Alzheimer's Disease

Year Published: 2015

Research increasingly suggests that subjective cognitive decline (SCD) in older adults, in the absence of objective cognitive dysfunction or depression, may be a harbinger of non-normative cognitive decline and eventual progression to dementia. Little is known, however, about the key features of self-report measures currently used to assess SCD. The Subjective Cognitive Decline Initiative (SCD-I) […]

Longitudinal cognitive decline in the AIBL cohort: The role of APOE ε4 status.

Authors: Albrecht MA, Ames D, Ellis KA, Foster JK, Lautenschlager NT, Martins R, Maruff P, Masters CL, Savage G, Szoeke C, Taddei K

Journal: Neuropsychologia

Volume & Issue: 75

Page No.: 411-419

DOI: 10.1016/j.neuropsychologia.2015.06.008

Year Published: 2015

The ε4 polymorphism of the APOE gene confers a substantially increased risk of developing Alzheimer’s disease. However, the influence of the ε4 allele on age-related cognitive functioning is more contentious. Previously, we demonstrated relatively little evidence for a role of the ε4 allele on baseline cognitive performance in older adults in the Australian Imaging, Biomarkers […]

Performance of the CogState computerized battery in the Mayo Clinic Study on Aging

Authors: Edwards KK, Hagen CE, Jack CR, Knopman DS, Machulda MM, Mielke MM, Pankratz VS, Petersen RC, Roberts RO

Journal: Alzheimer's and Dementia

DOI: 10.1016/j.jalz.2015.01.008

Year Published: 2015

BACKGROUND: The feasibility and validity of brief computerized cognitive batteries at the population-level are unknown. METHODS: Nondemented participants (n = 1660, age 50-97 years) in the Mayo Clinic Study on Aging completed the computerized CogState battery and standard neuropsychological battery. The correlation between tests was examined and comparisons between CogState performance on the personal computer (PC) and […]

Mild cognitive impairment can be detected by multiple assessments in a single day.

Authors: Collie A, Darby D, Maruff P, McStephen M

Journal: Neurology

Volume & Issue: 59 & 7

Page No.: 1042-6

Year Published: 2002

BACKGROUND: Reliable detection of mild cognitive impairment (MCI), in many cases preceding AD, is important in determining the efficacy of emerging treatments. The operational definition of MCI is currently imprecise and would be improved by objective criteria. Inherent in the transition from MCI to AD is cognitive decline, which can be detected using multiple assessments […]

Behavioral characterization of mild cognitive impairment.

Authors: Collie A, Currie J, Maruff P

Journal: Journal of Clinical and Experimental Neuropsychology

Volume & Issue: 24 & 6

Page No.: 720-33

Year Published: 2002

Results from recent investigations of behavioral and genetic outcomes in older people with mild cognitive impairment (MCI) have been inconsistent. These conflicting results may be attributed to between-study differences in the diagnostic systems employed, as well as the use of unreliable neuropsychological measures. We investigated behavioral and genetic outcomes in older people classified as having […]

Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort.

Authors: Craig DW, Dechairo BM, Foroud T, Huentelman MJ, Jack CR Jr, Kim S, Moore JH, Nho K, Pankratz N, Potkin SG, Risacher SL, Saykin AJ, Shen L, Sloan CD, Swaminathan S, Weiner MW, West JD

Journal: NeuroImage

Volume & Issue: 53 & 3

Page No.: 1051-63

DOI: 10.1016/j.neuroimage.2010.01.042

Year Published: 2010

A genome-wide, whole brain approach to investigate genetic effects on neuroimaging phenotypes for identifying quantitative trait loci is described. The Alzheimer’s Disease Neuroimaging Initiative 1.5 T MRI and genetic dataset was investigated using voxel-based morphometry (VBM) and FreeSurfer parcellation followed by genome-wide association studies (GWAS). One hundred forty-two measures of grey matter (GM) density, volume, […]

Voxelwise genome-wide association study (vGWAS).

Authors: Allen AN, Corneveaux JJ, Craig DW, Dechairo BM, Foroud T, Gerber JD, Ho AJ, Hua X, Huentelman MJ, Lee S, Leow AD, Pankratz N, Potkin SG, Saykin AJ, Shen L, Stein JL, Thompson P, Toga AW, Weiner MW

Journal: NeuroImage

Volume & Issue: 53 & 3

Page No.: 1160-74

DOI: 10.1016/j.neuroimage.2010.02.032

Year Published: 2010

The structure of the human brain is highly heritable, and is thought to be influenced by many common genetic variants, many of which are currently unknown. Recent advances in neuroimaging and genetics have allowed collection of both highly detailed structural brain scans and genome-wide genotype information. This wealth of information presents a new opportunity to […]

Effects of BDNF Val66Met polymorphism on brain metabolism in Alzheimer’s disease.

Authors: Fan M, Jiang T, Liu B, Song M, Wang Z, Xu C, Zhen X

Journal: Neuroreport

Volume & Issue: 21 & 12

Page No.: 802-7

DOI: 10.1097/WNR.0b013e32833ccaf4

Year Published: 2010

Earlier studies showed that the Val66Met polymorphisms of the brain-derived neurotrophic factor differentially affect gray matter volume and brain region activities. This study used resting positron emission tomography to investigate the relationship between the polymorphisms of Val66Met and the regional cerebral metabolic rate in the brain. We analyzed the positron emission tomography images of 215 […]

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