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Vortioxetine for major depressive disorder, vasomotor, and cognitive symptoms associated with the menopausal transition.

Authors: Cheng LJ, Cohen LS, Davies A, Freeman MP, Hogan C, Moustafa D, Petrillo LF, Sosinsky AZ, Wang B

Journal: Annals of Clinical Psychiatry

Volume & Issue: 29 & 4

Page No.: 249-257

Year Published: 2017

BACKGROUND: In a preliminary trial, we assessed the efficacy of vortioxetine for major depressive disorder (MDD) during the menopausal transition. Secondary outcomes included hot flashes (HFs), anxiety, and cognitive complaints. METHODS: Perimenopausal and early postmenopausal women with MDD (N = 27) received 8 weeks of open-label, flexible-dose treatment with vortioxetine. The Montgomery-Åsberg Depression Rating Scale […]

Testosterone improves verbal learning and memory in postmenopausal women: Results from a pilot study.

Authors: Adams J, Bell RJ, Davis SR, Davison SL, Egan GF, Gavrilescu M, Gogos A, Maruff P, Rossell SL, Searle K

Journal: Maturitas

Volume & Issue: 70 & 3

Page No.: 307-11

DOI: 10.1016/j.maturitas.2011.08.006

Year Published: 2011

OBJECTIVE: To explore the effects of testosterone on cognitive performance in healthy postmenopausal women. STUDY DESIGN: Open-label pilot study. Nine postmenopausal women on non-oral hormone replacement therapy, aged 47-60 years received transdermal testosterone spray for 26 weeks. A control group of 30 women provided normative data for comparison. MAIN OUTCOME MEASURES: Scores from a computerized […]

Continuous-combined oral estradiol/drospirenone has no detrimental effect on cognitive performance and improves estrogen deficiency symptoms in early postmenopausal women: a randomized placebo-controlled trial.

Authors: Bell RJ, Davis SR, Davison SL, Egan GF, Jane F, Leech J, Maruff P, Robinson PJ

Journal: Menopause

Volume & Issue: 20 & 10

Page No.: 1020-6

DOI: 10.1097/GME.0b013e318287474f

Year Published: 2013

OBJECTIVE: This study aimed to explore the effects of continuous-combined estradiol 1 mg/drospirenone 2 mg (E2D) on cognitive performance in healthy, recently postmenopausal women. METHODS: A 6-month randomized, double-blind, placebo-controlled study was carried out in a university research center. Participants were 23 healthy postmenopausal women aged 49 to 55 years. Cognitive performance was assessed with […]