major depressive disorder

Neurocognitive effects of repeated ketamine infusions in comorbid posttraumatic stress disorder and major depressive disorder

Authors: C Sophia Albott, Kelvin O Lim, Christopher Erbes, Paul Thuras, Joseph Wels, Susanna J Tye, Paulo R Shiroma

Journal: Journal of Affective Disorders

Year Published: 2022

Background: The glutamate N-methyl-d-aspartate (NMDA) receptor antagonist ketamine rapidly ameliorates posttraumatic stress disorder (PTSD) and depression symptoms in individuals with comorbid PTSD and major depressive disorder (MDD). However, concerns over ketamine’s potential neurocognitive side effects have […]

Preliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measures

Authors: Margaret T Davis, Nicole DellaGioia, David Matuskey, Brian Harel, Paul Maruff, Robert H Pietrzak, Irina Esterlis

Journal: Journal of Affective Disorders

Year Published: 2017

Background: Cognitive deficits are common in individuals with major depressive disorder (MDD), and are associated with treatment non-responsiveness and poorer functional outcomes. Characterization of the nature and magnitude of deficits in this population has been limited […]

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