Magnetic resonance spectroscopy

Does efavirenz replacement improve neurological function in treated HIV infection?

Authors: B Payne, T J Chadwick, A Blamire, K N Anderson, J Parikh, J Qian, A M Hynes, J Wilkinson, D A Price, Efficacy of Switch to Lopinavir/Ritonavir in Improving Cognitive Function in Efavirenz-treated Patients (SLICE) study team

Journal: HIV Medicine

Year Published: 2017

Objectives: The contribution of specific antiretroviral drugs to cognitive function in HIV-infected people remains poorly understood. Efavirenz (EFV) may plausibly cause cognitive impairment. The objective of this study was therefore to determine whether chronic EFV therapy […]

Cerebral function in perinatally HIV-infected young adults and their HIV-uninfected sibling controls

Authors: Jane Ashby, Caroline Foster, Lucy Garvey, Tania Wan, Joanna Allsop, Yasotharan Paramesparan, Simon D Taylor-Robinson, Sarah Fidler, Alan Winston

Journal: HIV Clinical Trials

Year Published: 2015

Background: Perinatally acquired HIV-infected (PaHIV) young adults undergo neurodevelopment in the presence of HIV infection and antiretroviral therapy, which may lead to neurocognitive (NC) impairment. Knowledge of NC function in this group is sparse and control […]

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