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Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults.

Authors: Bruce D, Burnham S, Dore V, Fraser PE, Gaskin S, Laws SM, Li QX, Martins RN, Maruff P, Masters CL, Newsholme P, Porter T, Rainey-Smith S, Rowe CC, Salvado O, Srikanth V, Verdile G, Villemagne VL, Wijesekara N, Woodfield A

Journal: Scientific Reports

Volume & Issue: 7 & 1

Page No.: 9766

DOI: 10.1038/s41598-017-09577-4

Year Published: 2017

Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of developing dementia. Experimental evidence from mouse models demonstrates that the induction of T2D/insulin resistance (IR) can promote the accumulation of Alzheimer’s disease (AD) pathological features. However, the association of T2D with pathological and clinical phenotypes in humans is unclear. Here we […]