Effect of hyperbilirubinaemia on neurocognitive, renal, bone and cardiovascular markers in HIV infection treated with boosted protease inhibitors

Authors: Tristan J Barber, Graeme Moyle, Andrew Hill, Gurmit Jagjit Singh, Marta Boffito, Mark Nelson

Journal: Journal of the International AIDS Society

Year Published: 2014

Introduction: Use of some protease inhibitors (PI) is associated with unconjugated hyperbilirubinaemia (HBR), due to inhibition of UGT1A1. As observed in Gilbert’s syndrome, HBR may have antioxidant and anti-inflammatory effects. Inflammation may be relevant to neurocognitive […]

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