Variable objective sleep quality is related to worse spatial learning and memory in young adults
Objective The majority of research on sleep and cognition has focused on mean markers of sleep across multiple nights; however, variable sleep patterns have become increasingly common in the modern era. The purpose of this study […]
Relationships Between Performance on the Cogstate Brief Battery, Neurodegeneration, and Aβ Accumulation in Cognitively Normal Older Adults and Adults With MCI
We investigated the extent to which decline in memory and working memory in beta-amyloid (Aβ) positive non-demented individuals was related to hippocampal atrophy and Aβ accumulation over 36 months. Cognitively normal older adults (CN) (n = […]
A randomized, double-blind, placebo-controlled, 16-week study of the H3 receptor antagonist, GSK239512 as a monotherapy in subjects with mild-to-moderate Alzheimer’s disease
Introduction: Histaminergic H3 receptors may play a role in modulating cholinergic and monoaminergic neurotransmission. This Phase II study evaluated the efficacy and safety of GSK239512, a highly potent, brain penetrant H3 receptor antagonist as monotherapy treatment […]
