episodic memory

Variable objective sleep quality is related to worse spatial learning and memory in young adults

Authors: Jordan Stiver, Benjamin Fusco-Gessick, Eileen Moran, Cara Crook, Molly E Zimmerman

Journal: Sleep Medicine

Year Published: 2021

Objective The majority of research on sleep and cognition has focused on mean markers of sleep across multiple nights; however, variable sleep patterns have become increasingly common in the modern era. The purpose of this study […]

Relationships Between Performance on the Cogstate Brief Battery, Neurodegeneration, and Aβ Accumulation in Cognitively Normal Older Adults and Adults With MCI

Authors: Yen Ying Lim, Robert H Pietrzak, Pierrick Bourgeat, David Ames, Kathryn A Ellis, Alan Rembach, Karra Harrington, Olivier Salvado, Ralph N Martins, Peter J Snyder, Colin L Masters, Christopher C Rowe, Victor L Villemagne, Paul Maruff

Journal: Archives of Clinical Neuropsychology

Year Published: 2015

We investigated the extent to which decline in memory and working memory in beta-amyloid (Aβ) positive non-demented individuals was related to hippocampal atrophy and Aβ accumulation over 36 months. Cognitively normal older adults (CN) (n = […]

A randomized, double-blind, placebo-controlled, 16-week study of the H3 receptor antagonist, GSK239512 as a monotherapy in subjects with mild-to-moderate Alzheimer’s disease

Authors: Richard A Grove, Conn M Harrington, Andreas Mahler, Isabel Beresford, Paul Maruff, Martin T Lowy, Andrew P Nicholls, Rebecca L Boardley, Alienor C Berges, Pradeep J Nathan, Joseph P Horrigan

Journal: Current Alzheimer Research

Year Published: 2014

Introduction: Histaminergic H3 receptors may play a role in modulating cholinergic and monoaminergic neurotransmission. This Phase II study evaluated the efficacy and safety of GSK239512, a highly potent, brain penetrant H3 receptor antagonist as monotherapy treatment […]

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