dual antigen targeting (3-10)

CD19/22 CAR T-cells in Children and Young Adults with B-ALL: Phase I Results and Development of a Novel Bicistronic CAR

Authors: Haneen Shalabi, Haiying Qin, Angela Su, Bonnie Yates, Pamela L. Wolters, Seth M Steinberg, John A Ligon, Sara Silbert, Kniya DéDé, Mehdi Benzaoui, Sophia Yael Goldberg, Sooraj Achar, Dina Schneider, Shilpa A Shahani, Lauren Little, Toni Foley, John C Molina, Sandhya Panch, Crystal L. Mackall, Daniel W. Lee, Christopher D Chien, Marie Pouzolles, Mark A Ahlman, Constance M Yuan, Hao-Wei Wang, Yanyu Wang, Jon Inglefield, Mary Anne Tamula, Staci Martin, Steven L Highfill, Gregoire Altan-Bonnet, David F Stroncek, Terry J Fry, Naomi Taylor, Nirali N Shah

Journal: Blood

Year Published: 2022

Remission durability following single-antigen targeted chimeric antigen receptor (CAR) T-cells is limited by antigen modulation, which may be overcome with combinatorial targeting. Building upon our experiences targeting CD19 and CD22 in B-cell acute lymphoblastic leukemia (B-ALL), […]

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