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Disrupted in schizophrenia 1 (DISC1): association with schizophrenia, schizoaffective disorder, and bipolar disorder.

Authors: Goldman D, Hodgkinson CA, Jaeger J, Kane JM, Lipsky RH, Malhotra AK, Persaud S

Journal: American Journal of Human Genetics

Volume & Issue: 75 & 5

Page No.: 862-72

Year Published: 2004

Schizophrenia, schizoaffective disorder, and bipolar disorder are common psychiatric disorders with high heritabilities and variable phenotypes. The Disrupted in Schizophrenia 1 (DISC1) gene, on chromosome 1q42, was originally discovered and linked to schizophrenia in a Scottish kindred carrying a balanced translocation that disrupts DISC1 and DISC2. More recently, DISC1 was linked to schizophrenia, broadly defined, […]