A phase 2, double-blind, placebo-controlled study of NSI-189 phosphate, a neurogenic compound, among outpatients with major depressive disorder

Authors: G. I. Papakostas, K. Johe, H. Hand, A. Drouillard, P. Russo, G. Kay, R. Kashambwa, B. Hoeppner, M. Flynn, A. Yeung, M. A. Martinson & M. Fava

Journal: Molecular Psychiatry

Year Published: 2019

NSI-189 is a novel neurogenic compound independent of monoamine reuptake pathways. This trial evaluated oral NSI-189 as monotherapy in major depressive disorder. To improve signal detection, the sequential-parallel comparison design (SPCD) was chosen. Two hundred and […]

The relationship between depression and cognitive function in adults with cardiovascular risk: Evidence from a randomised attention-controlled trial

Authors: Haley M LaMonica, Daniel J Biddle, Sharon L Naismith, Ian B Hickie, Paul Maruff, Nicholas Glozier

Journal: PloS One

Year Published: 2018

Background and Aim This study assessed the association between depressive symptom severity and cognition in middle-to-older aged adults with mild-to-moderate depression and cardiovascular risk factors using an online test battery (CogState) and whether changes in depressive […]

Impaired visual, working, and verbal memory in first-episode, drug-naive patients with major depressive disorder in a Chinese population

Authors: Ce Chen, Wen-Hui Jiang, Wei Wang, Xian-Cang Ma, Ye Li, Jin Wu, Kenji Hashimoto, Cheng-Ge Gao

Journal: Public Library of Science One

Year Published: 2018

Cognitive impairment has been observed in patients with major depressive disorder (MDD). However, it remains unclear whether the deficits in specific cognitive domains are present in first-episode, drug-naïve patients or medicated patients. In the present study, […]

The Beneficial Effects of Cognitive Training With Simple Calculation and Reading Aloud (SCRA) in the Elderly Postoperative Population: A Pilot Randomized Controlled Trial

Authors: Kay Kulason, Rui Nouchi, Yasushi Hoshikawa, Masafumi Noda, Yoshinori Okada, Ryuta Kawashima

Journal: Frontiers in Aging Neuroscience

Year Published: 2018

Background: There has been little research conducted regarding cognitive treatments for the elderly postsurgical population. Patients aged ≥60 years have an increased risk of postoperative cognitive decline, a condition in which cognitive functions are negatively affected. […]

Posttraumatic stress disorder symptoms and cognitive function in a large cohort of middle-aged women

Authors: Jennifer A Sumner, Kaitlin Hagan, Fran Grodstein, Andrea L Roberts, Brian Harel, Karestan C Koenen

Journal: Depression and Anxiety

Year Published: 2017

Background: Posttraumatic stress disorder (PTSD) has been linked to cognitive decline, but research in women is generally lacking. We examined whether trauma and elevated PTSD symptoms were associated with worse cognitive function in middle-aged civilian women. […]

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