Access hundreds of peer-reviewed cognitive research papers published by leading neuroscientists using Cogstate technology.



The Beneficial Effects of Cognitive Training With Simple Calculation and Reading Aloud (SCRA) in the Elderly Postoperative Population: A Pilot Randomized Controlled Trial.

Authors: Hoshikawa Y, Kawashima R, Kulason K, Noda M, Nouchi R, Okada Y

Journal: Frontiers in Aging Neuroscience

DOI: 10.3389/fnagi.2018.00068

Year Published: 2018

Background: There has been little research conducted regarding cognitive treatments for the elderly postsurgical population. Patients aged ≥60 years have an increased risk of postoperative cognitive decline, a condition in which cognitive functions are negatively affected. This cognitive decline can lead to a decline in quality of life. In order to maintain a high quality […]

Sleep and cognition in older adults: Does depression matter? An actigraphy and polysomnography study

Authors: Alix Mellor, Flavie Waters, Helen McGowan, Jennifer Maul, Katherine A. Sanders, Romola S. Bucks

Journal: Archives of Psychology

Volume & Issue: 2 & 1

Year Published: 2018

The impact of sleep on cognition is well recognised, although research in older adults is lacking, as are investigations into how depression might impact on this relationship. This study assessed the relationship between sleep (assessed with actigraphy and polysomnography) and cognitive performance in older adults (50–78 years) with (n = 10) and without (n = […]

Prevalence of cognitive impairment in major depression and bipolar disorder

Authors: Allan H Young, Christopher MA Frampton, I Nicol Ferrier, Janet D Carter, Katie M Douglas, Lucy J Robinson, Peter Gallagher, Richard J Porter, Stuart Watson, Virginia VW McIntosh

Journal: Bipolar Disorders

DOI: 10.1111/bdi.12602

Year Published: 2018

Objectives: The current study examines prevalence of cognitive impairment in four mood disorder samples, using four definitions of impairment. The impact of premorbid IQ on prevalence was examined, and the influence of treatment response. Methods: Samples were: (i) 58 inpatients in a current severe depressive episode (unipolar or bipolar), (ii) 69 unmedicated outpatients in a […]

Trajectories of depressive and anxiety symptoms in older adults: a 6-year prospective cohort study.

Authors: Ames D, Dore V, Ellis K, Esterlis I, Fowler C, Holmes SE, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Mazure CM, Pietrzak RH, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL

Journal: International Journal of Geriatric Psychiatry

DOI: 10.1002/gps.4761

Year Published: 2017

OBJECTIVE: Depressive and anxiety symptoms are common in older adults, significantly affect quality of life, and are risk factors for Alzheimer’s disease. We sought to identify the determinants of predominant trajectories of depressive and anxiety symptoms in cognitively normal older adults. METHOD: Four hundred twenty-three older adults recruited from the general community underwent Aβ positron […]

Posttraumatic stress disorder symptoms and cognitive function in a large cohort of middle-aged women.

Authors: Grodstein F, Hagan K, Harel B, Koenen KC, Roberts AL, Sumner JA

Journal: Depression and Anxiety

Volume & Issue: 34 & 4

Page No.: 356-366

DOI: 10.1002/da.22600

Year Published: 2017

BACKGROUND: Posttraumatic stress disorder (PTSD) has been linked to cognitive decline, but research in women is generally lacking. We examined whether trauma and elevated PTSD symptoms were associated with worse cognitive function in middle-aged civilian women. A secondary objective was to investigate the possible role of depression in the relation of PTSD symptoms to cognitive […]

Do Wellness Tourists Get Well? An Observational Study of Multiple Dimensions of Health and Well-Being After a Week-Long Retreat.

Authors: Cohen MM, Elliott F, Mantri N, Oates L, Schembri A

Journal: Journal of Alternative and Complementary Medicine

Volume & Issue: 23 & 2

Page No.: 140-148

DOI: 10.1089/acm.2016.0268

Year Published: 2017

BACKGROUND: Wellness retreats use many complementary and alternative therapies within a holistic residential setting, yet few studies have evaluated the effect of retreat experiences on multiple dimensions of health and well-being, and no published studies have reported health outcomes in wellness tourists. OBJECTIVES: To assess the effect of a week-long wellness-retreat experience in wellness tourists. […]

β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men.

Authors: Ames D, Dore V, Esterlis I, Holmes SE, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Mazure CM, Pietrzak RH, Rainey-Smith S, Rowe CC, Salvado O, Villemagne VL

Journal: The American Journal of Geriatric Psychiatry

Volume & Issue: 24 & 12

Page No.: 1191-1195

DOI: 10.1016/j.jagp.2016.08.007

Year Published: 2016

OBJECTIVE: To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. METHODS: Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol […]

Amyloid burden and incident depressive symptoms in cognitively normal older adults.

Authors: Ames D, Gould E, Harrington KD, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rainey-Smith S, Rembach A, Rowe CC, Salvado O, Villemagne VL

Journal: International Journal of Geriatric Psychiatry

DOI: 10.1002/gps.4489

Year Published: 2016

OBJECTIVE: Several studies have reported that non-demented older adults with clinical depression show changes in amyloid-β (Aβ) levels in blood, cerebrospinal fluid and on neuroimaging that are consistent with those observed in patients with Alzheimer’s disease. These findings suggest that Aβ may be one of the mechanisms underlying the relation between the two conditions. We […]

Ventilatory Response to Hypercapnia Predicts Dementia with Lewy Bodies in Late-Onset Major Depressive Disorder.

Authors: Arai T, Asada T, Darby D, Hattori S, Kikuchi N, Mizukami K, Ogawa R, Takahashi S

Year Published: 2016

BACKGROUND: Studies have shown that developing major depressive disorder (MDD) at 50 years of age or older can predict dementia. Depression is particularly common in dementia with Lewy bodies (DLB), and occasionally occurs before the onset of extrapyramidal symptoms. Moreover, systemic autonomic dysfunction, including an abnormal ventilatory response to hypercapnia (VRH), is common in patients […]

Phenomenological Characterization of Memory Complaints in Preclinical and Prodromal Alzheimer’s Disease

Authors: Ames D, Buckley RF, Ellis KA, Lautenschlager NT, Macaulay SL, Martins RN, Maruff P, Masters CL, Rainey-Smith SR, Rembach A, Rowe CC, Saling MM, Savage G, Szoeke C, Villemagne VL

Journal: Neuropsychology

Year Published: 2015

Objective: To explore the subjective experience of memory change in groups at risk of dementia (those with mild cognitive impairment MCI or high β-amyloid (Aβ+) burden) to determine the existence of potential phenomenological typologies. Method: We recruited 123 healthy controls (HC) and individuals with MCI from the Australian Imaging, Biomarker and Lifestyle (AIBL) study. Sixty-7 […]

Neuropsychological changes and treatment response in severe depression.

Authors: Douglas KM, Knight RG, Maruff P, Porter RJ

Journal: The British Journal of Psychiatry

Volume & Issue: 198 & 2

Page No.: 115-22

DOI: 10.1192/bjp.bp.110.080713

Year Published: 2011

BACKGROUND: Impaired neuropsychological function and differences in facial emotion processing are features of major depression. Some aspects of these functions may change during treatment and may be useful in assessing treatment response, even at an early stage of treatment. AIMS: To examine early and later changes in neuropsychological functioning and facial emotion processing as potential […]

Amyloid-beta and depression in healthy older adults: A systematic review

Authors: Gould E, Harrington KD, Lim YY, Maruff P

Journal: The Australian and New Zealand Journal of Psychiatry

Year Published: 2014

OBJECTIVE: Depression has been shown to be a risk factor for Alzheimer’s disease (AD), and in older adults may provide a marker for the beginning of the prodromal phase of AD. The purpose of this systematic review is to examine the relationship between amyloid-β (Aβ), a key biomarker of AD, and depression in older adults. […]

Amyloid-β Related Memory Decline is not Associated with Subjective or Informant Rated Cognitive Impairment in Healthy Adults.

Authors: Ames D, Buckley R, Ellis KA, Harrington K, Hollands S, Lautenschlager N, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rowe CC, Snyder PJ, Villemagne VL

Journal: Journal of Alzheimer's Disease

Year Published: 2014

BACKGROUND: The detection of early Alzheimer’s disease (AD) can rely on subjective and informant reports of cognitive impairment. However, relationships between subjective cognitive impairment, objectively measured cognitive function, and amyloid-β (Aβ) biomarkers remain unclear. Objective: To determine the extent to which impairment or decline in subjective and informant rated cognitive impairment was associated with memory […]

Development and reliability of the HAM-D/MADRS interview: An integrated depression symptom rating scale.

Authors: Goldberg JF, Iannuzzo RW, Jaeger J, Kafantaris V, Sublette ME

Journal: Psychiatry Research

Volume & Issue: 145 & 1

Page No.: 21-37

Year Published: 2006

The Hamilton Rating Scale for Depression (HAM-D) and the Montgomery-Asberg Depression Rating Scale (MADRS), two widely used depression scales, each have unique advantages and limitations for research. The HAM-D’s limited sensitivity and multidimensionality have been criticized, despite the scale’s popularity. The MADRS, designed to be sensitive to treatment changes, is briefer and more uniform. A […]

Quetiapine augmentation in depressed patients with partial response to antidepressants.

Authors: Burrows GD, Ignatiadis S, Maruff P, Norman TR, Olver JS

Journal: Human Psychopharmacology

Volume & Issue: 23 & 8

Page No.: 653-60

DOI: 10.1002/hup.970

Year Published: 2008

OBJECTIVE: Clinical trials suggest between 30-50% of depressed patients have an inadequate outcome to antidepressant pharmacotherapy. Among the approaches to improve outcome has been augmentation with antipsychotic medications. We aim to investigate the efficacy and tolerability of augmentation with quetiapine in depressed patients with a partial response to antidepressants. METHODS: Patients with a Major Depressive […]

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