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Cognitive Function Before and After Left Heart Catheterization.

Authors: Evered L, MacIsaac A, Maher S, Maruff P, Scott DA, Silbert BS

Journal: Journal of the American Heart Association

Volume & Issue: 7 & 6

DOI: 10.1161/JAHA.117.008004

Year Published: 2018

BACKGROUND: Hospital procedures have been associated with cognitive change in older patients. This study aimed to document the prevalence of mild cognitive impairment in individuals undergoing left heart catheterization (LHC) before the procedure and the incidence of cognitive decline to 3 months afterwards. METHODS AND RESULTS: We conducted a prospective, observational, clinical investigation of elderly […]

Prevalence of cognitive impairment in major depression and bipolar disorder

Authors: Allan H Young, Christopher MA Frampton, I Nicol Ferrier, Janet D Carter, Katie M Douglas, Lucy J Robinson, Peter Gallagher, Richard J Porter, Stuart Watson, Virginia VW McIntosh

Journal: Bipolar Disorders

DOI: 10.1111/bdi.12602

Year Published: 2018

Objectives: The current study examines prevalence of cognitive impairment in four mood disorder samples, using four definitions of impairment. The impact of premorbid IQ on prevalence was examined, and the influence of treatment response. Methods: Samples were: (i) 58 inpatients in a current severe depressive episode (unipolar or bipolar), (ii) 69 unmedicated outpatients in a […]

Recent and Long-Term Soccer Heading Exposure Is Differentially Associated With Neuropsychological Function in Amateur Players

Authors: Cara F. Levitch, Michael L. Lipton, Mimi Kim, Molly E. Zimmerman, Namhee Kim, Naomi Lubin, Richard B. Lipton, Walter F. Stewart

Journal: Journal of the International Neuropsychological Society

Volume & Issue: 24

Page No.: 147-155

DOI: 10.1017/S1355617717000790

Year Published: 2018

Objectives: The present study examined the relative contribution of recent or long-term heading to neuropsychological function in amateur adult soccer players. Participants and Methods: Soccer players completed a baseline questionnaire (HeadCount-12m) to ascertain heading during the prior 12 months (long-term heading, LTH) and an online questionnaire (HeadCount-2w) every 3 months to ascertain heading during the […]

Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment.

Authors: Anton S, Barrett-Connor E, Basaria S, Bhasin S, Cauley JA, Cella D, Cifelli D, Crandall JP, Cunningham GR, Diem SJ, Ellenberg SS, Ensrud KE, Farrar JT, Gill TM, Hou X, Lewis CE, Matsumoto AM, Molitch ME, Pahor M, Pleasants DD, Resnick SM, Shumaker SA, Snyder PJ, Stephens-Shields AJ, Swerdloff RS, Wang C

Journal: Journal of the American Medical Association

Volume & Issue: 317 & 7

Page No.: 717-727

DOI: 10.1001/jama.2016.21044

Year Published: 2017

Importance: Most cognitive functions decline with age. Prior studies suggest that testosterone treatment may improve these functions. Objective: To determine if testosterone treatment compared with placebo is associated with improved verbal memory and other cognitive functions in older men with low testosterone and age-associated memory impairment (AAMI). Design, Setting, and Participants: The Testosterone Trials (TTrials) […]

Recent and Long-Term Soccer Heading Exposure Is Differentially Associated With Neuropsychological Function in Amateur Players.

Authors: Kim M, Kim N, Levitch CF, Lipton ML, Lipton RB, Lubin N, Stewart WF, Zimmerman ME

Journal: Journal of the International Neuropsychological Society

Page No.: 1-9

DOI: 10.1017/S1355617717000790

Year Published: 2017

OBJECTIVES: The present study examined the relative contribution of recent or long-term heading to neuropsychological function in amateur adult soccer players. PARTICIPANTS AND METHODS: Soccer players completed a baseline questionnaire (HeadCount-12m) to ascertain heading during the prior 12 months (long-term heading, LTH) and an online questionnaire (HeadCount-2w) every 3 months to ascertain heading during the […]

Does efavirenz replacement improve neurological function in treated HIV infection?

Authors: Anderson KN, Blamire A, Chadwick TJ, Hynes AM, Parikh J, Payne B, Price DA, Qian J, Wilkinson J

Journal: HIV Medicine

Volume & Issue: 18 & 9

Page No.: 690-695

DOI: 10.1111/hiv.12503

Year Published: 2017

OBJECTIVES: The contribution of specific antiretroviral drugs to cognitive function in HIV-infected people remains poorly understood. Efavirenz (EFV) may plausibly cause cognitive impairment. The objective of this study was therefore to determine whether chronic EFV therapy is a modifier of neurocognitive and neurometabolic function in the setting of suppressive highly active antiretroviral therapy. METHODS: We […]

Associations between cognitive impairment and patient-reported measures of physical/mental functioning in older people living with HIV.

Authors: Anderson J, Boffito M, De Francesco D, Mallon PW, Post FA, Sabin C, Sachikonye M, Underwood J, Vera JH, Williams I, Winston A

Journal: HIV Medicine

DOI: 10.1111/hiv.12434

Year Published: 2016

OBJECTIVES: While cognitive impairment is frequently reported in HIV-positive individuals and has historically been associated with poorer functional outcomes, the associations between cognitive impairment and patient-reported outcome measures (PROMs) in contemporary cohorts are unclear. METHODS: We tested cognitive function using a computerized battery (CogState™ ) in 290 HIV-positive and 97 HIV-negative individuals aged ≥ 50 […]

Prevalence of Dementia 7.5 Years after Coronary Artery Bypass Graft Surgery.

Authors: Ames D, Evered LA, Maruff P, Scott DA, Silbert BS

Journal: Anesthesiology

Volume & Issue: 125

Page No.: 62-71

DOI: 10.1097/ALN.0000000000001143

Year Published: 2016

BACKGROUND: Although postoperative cognitive dysfunction (POCD) is well described after coronary artery bypass graft (CABG) surgery, a major concern has been that a progressive decline in cognition will ultimately lead to dementia. Since dementia interferes with the ability to carry out daily functions, the impact has far greater ramifications than cognitive decline defined purely by […]

Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer’s Disease.

Authors: Asthana S, Berman SE, Bilgel M, Blennow K, Carlsson CM, Christian BT, Clark LR, Jedynak B, Johnson SC, Koscik RL, Mueller KD, Nicholas CR, Norton D, Racine AM, Zetterberg H

Journal: Journal of Alzheimer's Disease

DOI: 10.3233/JAD-160528

Year Published: 2016

It is not known whether computerized cognitive assessments, like the CogState battery, are sensitive to preclinical cognitive changes or pathology in people at risk for Alzheimer’s disease(AD). In 469 late middle-aged participants from the Wisconsin Registry for Alzheimer’s Prevention(mean age 63.8±7 years at testing; 67% female; 39% APOE4+), we examined relationships between a CogState abbreviated […]

Neuropsychological Impairment and Its Association with Violence Risk in Japanese Forensic Psychiatric Patients: A Case-Control Study.

Authors: Hashimoto K, Hirabayashi N, Igarashi Y, Imai A, Kuroda O, Kuroki N, Nagata T, Nakane J, Nishinaka H, Omori M, Sakikawa N

Journal: Public Library of Science One

DOI: 10.1371/journal.pone.0148354

Year Published: 2016

BACKGROUND: In Japan, the legislation directing treatment of offenders with psychiatric disorders was enacted in 2005. Neuropsychological impairment is highly related to functional outcomes in patients with psychiatric disorders, and several studies have suggested an association between neuropsychological impairment and violent behaviors. However, there have been no studies of neuropsychological impairment in forensic patients covered […]

Neuropsychiatric symptoms among adult patients with aseptic meningitis: a prospective case series.

Authors: Age Lindberg J, Andersen H, Damsgaard J, Deutch S, Erlandsen M, Hagelskjaer Kristensen L, Hjerrild S, Leutscher PD, Marinovskij E, Schembri A, Tarp B

Journal: Acta Psychiatrica Scandinavica

DOI: 10.1111/acps.12539

Year Published: 2015

Alzheimer’s disease cerebrospinal fluid biomarkers are not influenced by gravity drip or aspiration extraction methodology.

Authors: Ames D, Collins S, Darby DG, Doecke JD, Evered LA, Farrow M, Fowler CJ, Laws SM, Li QX, Macaulay SL, Maher S, Martins RN, Masters CL, Mooney F, Nash T, Pertile KK, Rainey-Smith S, Rembach A, Rumble RL, Silbert B, Taddei K, Trounson BO, Vidaurre L, Wilson W

Journal: Alzheimer's Research & Therapy

Volume & Issue: 7 & 1

Page No.: 71

DOI: 10.1186/s13195-015-0157-7

Year Published: 2015

INTRODUCTION: Cerebrospinal fluid (CSF) biomarkers, although of established utility in the diagnostic evaluation of Alzheimer’s disease (AD), are known to be sensitive to variation based on pre-analytical sample processing. We assessed whether gravity droplet collection versus syringe aspiration was another factor influencing CSF biomarker analyte concentrations and reproducibility. METHODS: Standardized lumbar puncture using small calibre […]

Cerebrospinal Fluid Biomarker for Alzheimer Disease Predicts Postoperative Cognitive Dysfunction.

Authors: Ames D, Blennow K, Evered L, Maruff P, Scott DA, Silbert B

Journal: Anesthesiology

Year Published: 2015

BACKGROUND: Postoperative cognitive dysfunction (POCD) affects 16 to 21% of the elderly 3 months after anesthesia and surgery and is associated with adverse outcomes. The exact cause of POCD remains unknown. The authors hypothesized that elderly individuals with Alzheimer disease (AD) neuropathology, identified by cerebrospinal fluid (CSF) analysis, would have increased the risk for POCD. […]

A randomized controlled trial of light versus deep propofol sedation for elective outpatient colonoscopy: recall, procedural conditions, and recovery.

Authors: Allen M, Hebbard G, Jones I, Leslie K, Maruff P, Mettho T

Journal: Canadian Journal of Anaesthesia

DOI: 10.1007/s12630-015-0463-3

Year Published: 2015

PURPOSE: This study aimed to determine if the incidence of recall was equivalent between light and deep sedation for colonoscopy. Secondary analysis included complications, patient clinical recovery, and post-procedure cognitive impairment. METHODS: Two hundred patients undergoing elective outpatient colonoscopy were randomized to light (bispectral index [BIS] 70-80) or deep (BIS < 60) sedation with propofol […]

Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months.

Authors: Ames D, Ellis KA, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Rainey-Smith SR, Rowe CC, Thai C, Villemagne VL

Journal: PloS One

Volume & Issue: 10 & 10

DOI: 10.1371/journal.pone.0139082

Year Published: 2015

High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. However, the relationship between these two biomarkers and cognitive decline is unclear. The aim of this study was to investigate the relationship between cerebral Aβ level, APOE […]

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