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Computerized cognitive performance assessments in the Brooklyn Cognitive Impairments in Health Disparities Pilot Study.

Authors: Adler K, Apple S, Cheng F, Cohen C, Friedlander A, Gustafson D, Levine SR, Lucchesi M, Maruff P, Reinhardt M, Salmieri M, Stevens D, Weingast S

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2019.07.004

Year Published: 2019

INTRODUCTION: Detecting cognitive impairment in diverse, health disparities communities is an urgent health care priority. METHODS: The Brooklyn Cognitive Impairments in Health Disparities Pilot Study investigated quantitative aspects and liking of a computerized cognitive performance assessment, Cognigram, among individuals ≥ 40 years in traditional and nontraditional primary care settings. RESULTS: Cognigram was piloted in the […]

Associating Cognition With Amyloid Status Using Partially Ordered Set Analysis.

Authors: Bian S, Carr SJA, Chen Z, Enayetallah A, He P, Jaeger J, Lerner A, Maruff P, Maserejian N, Tatsuoka C, Wang W, Wang Y

Journal: Frontiers in Neurology

DOI: 10.3389/fneur.2019.00976

Year Published: 2019

Background: The presence of brain amyloid-beta positivity is associated with cognitive impairment and dementia, but whether there are specific aspects of cognition that are most linked to amyloid-beta is unclear. Analysis of neuropsychological test data presents challenges since a single test often requires drawing upon multiple cognitive functions to perform well. It can thus be […]

Protocol for a prospective cohort study of assessing postoperative cognitive changes after total hip and knee arthroplasty in the Greater Toronto area.

Authors: Au S, Avramescu S, Choi S, Orser BA

Journal: BMJ Open

DOI: 10.1136/bmjopen-2018-024259

Year Published: 2019

INTRODUCTION: Cognitive changes after anaesthesia and surgery, such as delirium and postoperative cognitive dysfunction (POCD), are common and lead to poor outcomes and increased healthcare costs. While several interventions for delirium exist, there are no effective treatment strategies for POCD. Understanding the risks and contributing factors may offer clinicians unique opportunities to better identify and […]

Comparing cognitive clusters across first- and multiple-episode of psychosis.

Authors: Brodeur MB, Joober R, Lepage M, Malla A, Sauvé G

Journal: Psychiatry Research

DOI: 10.1016/j.psychres.2018.08.119

Year Published: 2018

Cognitive impairments in psychotic disorders (PD) present heterogeneously across patients. Between 2 and 5 clusters have been identified in previous studies with first-episode (FEP) and multiple-episodes of psychosis (MEP) patients suggesting different profiles of impairment. Past findings suggest there are differences between FEP and MEP patients regarding severity and number of affected cognitive domains. Heterogeneity […]

Perioperative Research into Memory (PRiMe): Cognitive impairment following a severe burn injury and critical care admission, part 1.

Authors: Al-Hindawi A, Clancy OH, Edginton TL, Farag M, Mandalia S, Mehmet ART, Nenadlová K, Nilsen A, Nordin NA, Vizcaychipi MP, Watson EJR, Williams LM

Journal: Burns : journal of the International Society for Burn Injuries

DOI: 10.1016/j.burns.2018.04.011

Year Published: 2018

INTRODUCTION: An investigation into long-term cognitive impairment and Quality of Life (QoL) after severe burns. METHODS: A proof of principle, cohort design, prospective, observational clinical study. Patients with severe burns (>15% TBSA) admitted to Burns ICU for invasive ventilation were recruited for psychocognitive assessment with a convenience sample of age and sex-matched controls. Participants completed […]

Recent and Long-Term Soccer Heading Exposure Is Differentially Associated With Neuropsychological Function in Amateur Players.

Authors: Kim M, Kim N, Levitch CF, Lipton ML, Lipton RB, Lubin N, Stewart WF, Zimmerman ME

Journal: Journal of the International Neuropsychological Society

DOI: 10.1017/S1355617717000790

Year Published: 2017

OBJECTIVES: The present study examined the relative contribution of recent or long-term heading to neuropsychological function in amateur adult soccer players. PARTICIPANTS AND METHODS: Soccer players completed a baseline questionnaire (HeadCount-12m) to ascertain heading during the prior 12 months (long-term heading, LTH) and an online questionnaire (HeadCount-2w) every 3 months to ascertain heading during the […]

Does efavirenz replacement improve neurological function in treated HIV infection?

Authors: Anderson KN, Blamire A, Chadwick TJ, Hynes AM, Parikh J, Payne B, Price DA, Qian J, Wilkinson J

Journal: HIV Medicine

DOI: 10.1111/hiv.12503

Year Published: 2017

OBJECTIVES: The contribution of specific antiretroviral drugs to cognitive function in HIV-infected people remains poorly understood. Efavirenz (EFV) may plausibly cause cognitive impairment. The objective of this study was therefore to determine whether chronic EFV therapy is a modifier of neurocognitive and neurometabolic function in the setting of suppressive highly active antiretroviral therapy. METHODS: We […]

Associations between cognitive impairment and patient-reported measures of physical/mental functioning in older people living with HIV.

Authors: Anderson J, Boffito M, De Francesco D, Mallon PW, Post FA, Sabin C, Sachikonye M, Underwood J, Vera JH, Williams I, Winston A

Journal: HIV Medicine

DOI: 10.1111/hiv.12434

Year Published: 2016

OBJECTIVES: While cognitive impairment is frequently reported in HIV-positive individuals and has historically been associated with poorer functional outcomes, the associations between cognitive impairment and patient-reported outcome measures (PROMs) in contemporary cohorts are unclear. METHODS: We tested cognitive function using a computerized battery (CogState™ ) in 290 HIV-positive and 97 HIV-negative individuals aged ≥ 50 […]

Associations between Performance on an Abbreviated CogState Battery, Other Measures of Cognitive Function, and Biomarkers in People at Risk for Alzheimer’s Disease.

Authors: Asthana S, Berman SE, Bilgel M, Blennow K, Carlsson CM, Christian BT, Clark LR, Jedynak B, Johnson SC, Koscik RL, Mueller KD, Nicholas CR, Norton D, Racine AM, Zetterberg H

Journal: Journal of Alzheimer's Disease

DOI: 10.3233/JAD-160528

Year Published: 2016

It is not known whether computerized cognitive assessments, like the CogState battery, are sensitive to preclinical cognitive changes or pathology in people at risk for Alzheimer’s disease(AD). In 469 late middle-aged participants from the Wisconsin Registry for Alzheimer’s Prevention(mean age 63.8±7 years at testing; 67% female; 39% APOE4+), we examined relationships between a CogState abbreviated […]

Neuropsychological Impairment and Its Association with Violence Risk in Japanese Forensic Psychiatric Patients: A Case-Control Study.

Authors: Hashimoto K, Hirabayashi N, Igarashi Y, Imai A, Kuroda O, Kuroki N, Nagata T, Nakane J, Nishinaka H, Omori M, Sakikawa N

Journal: Public Library of Science One

DOI: 10.1371/journal.pone.0148354

Year Published: 2016

BACKGROUND: In Japan, the legislation directing treatment of offenders with psychiatric disorders was enacted in 2005. Neuropsychological impairment is highly related to functional outcomes in patients with psychiatric disorders, and several studies have suggested an association between neuropsychological impairment and violent behaviors. However, there have been no studies of neuropsychological impairment in forensic patients covered […]

Neuropsychiatric symptoms among adult patients with aseptic meningitis: a prospective case series.

Authors: Age Lindberg J, Andersen H, Damsgaard J, Deutch S, Erlandsen M, Hagelskjaer Kristensen L, Hjerrild S, Leutscher PD, Marinovskij E, Schembri A, Tarp B

Journal: Acta Psychiatrica Scandinavica

DOI: 10.1111/acps.12539

Year Published: 2015

A randomized controlled trial of light versus deep propofol sedation for elective outpatient colonoscopy: recall, procedural conditions, and recovery.

Authors: Allen M, Hebbard G, Jones I, Leslie K, Maruff P, Mettho T

Journal: Canadian Journal of Anaesthesia

DOI: 10.1007/s12630-015-0463-3

Year Published: 2015

PURPOSE: This study aimed to determine if the incidence of recall was equivalent between light and deep sedation for colonoscopy. Secondary analysis included complications, patient clinical recovery, and post-procedure cognitive impairment. METHODS: Two hundred patients undergoing elective outpatient colonoscopy were randomized to light (bispectral index [BIS] 70-80) or deep (BIS < 60) sedation with propofol […]

Amyloid-Related Memory Decline in Preclinical Alzheimer’s Disease Is Dependent on APOE ε4 and Is Detectable over 18-Months.

Authors: Ames D, Ellis KA, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Rainey-Smith SR, Rowe CC, Thai C, Villemagne VL

Journal: PloS One

DOI: 10.1371/journal.pone.0139082

Year Published: 2015

High levels of β-amyloid (Aβ) in the brain and carriage of the APOE ε4 allele have each been linked to cognitive impairment in cognitively normal (CN) older adults. However, the relationship between these two biomarkers and cognitive decline is unclear. The aim of this study was to investigate the relationship between cerebral Aβ level, APOE […]

Randomized, Double-Blind, Placebo-Controlled Study of Encenicline, an α7 Nicotinic Acetylcholine Receptor Agonist, as a Treatment for Cognitive Impairment in Schizophrenia.

Authors: Dgetluck N, Gawryl M, Hilt DC, Keefe RS, Koenig G, Lombardo I, Meltzer HA, Moebius HJ

Journal: Neuropsychopharmacology

DOI: 10.1038/npp.2015.176

Year Published: 2015

Encenicline is a novel, selective α7 nicotinic acetylcholine receptor agonist in development for treating cognitive impairment in schizophrenia and Alzheimer’s disease. A phase 2, double-blind, randomized, placebo-controlled, parallel-design, multinational study was conducted. Patients with schizophrenia on chronic stable atypical antipsychotics were randomized to encenicline 0.27 or 0.9 mg once daily or placebo for 12 weeks. The […]

Early cognitive impairment after sedation for colonoscopy: the effect of adding midazolam and/or fentanyl to propofol.

Authors: Eer AS, Leslie K, Maruff P, Padmanabhan U, Silbert BS

Journal: Anesthesia and Analgesia

DOI: 10.1213/ane.0b013e3181a6ad31

Year Published: 2009

BACKGROUND: The sedative drug combination that produces minimal cognitive impairment and optimal operating conditions during colonoscopy has not been determined. We sought to determine if the use of propofol alone results in less cognitive impairment at discharge than the use of propofol plus midazolam and/or fentanyl in patients presenting for elective outpatient colonoscopy. METHODS: Two […]

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2014 Report on the Milestones for the US National Plan to Address Alzheimer’s Disease.

Authors: Aisen P, Albert M, Au R, Bain LJ, Carrillo MC, Corrada MM, DeKosky S, Drachman D, Fargo KN, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, Klunk W, Knopman D, Kukull WA, Lamb B, Logsdon RG, Maruff P, Mesulam M, Mobley W, Mohs R, Morgan D, Nixon RA, Paul S, Petersen R, Plassman B, Potter W, Reiman E, Reisberg B, Sano M, Schindler R, Schneider LS, Snyder PJ, Sperling RA, Thies WH, Yaffe K

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2014.08.103

Year Published: 2014

With increasing numbers of people with Alzheimer’s and other dementias across the globe, many countries have developed national plans to deal with the resulting challenges. In the United States, the National Alzheimer’s Project Act, signed into law in 2011, required the creation of such a plan with annual updates thereafter. Pursuant to this, the US […]

A combination of physical activity and computerized brain training improves verbal memory and increases cerebral glucose metabolism in the elderly.

Authors: Campbell A, Cheetham C, Darby D, Dhaliwal S, Martins RN, Maruff P, Putland E, Shah T, Sohrabi H, Verdile G, Weinborn M

Journal: Translational Psychiatry

DOI: 10.1038/tp.2014.122

Year Published: 2014

Physical exercise interventions and cognitive training programs have individually been reported to improve cognition in the healthy elderly population; however, the clinical significance of using a combined approach is currently lacking. This study evaluated whether physical activity (PA), computerized cognitive training and/or a combination of both could improve cognition. In this nonrandomized study, 224 healthy […]

A comparative study of two acoustic measures of hypernasality.

Authors: Ibrahim HM, Kilpatrick N, Reilly S, Vogel AP

Journals: Journal of Speech, Language

DOI: 10.1044/1092-4388(2009/08-0161)

Year Published: 2009

PURPOSE: This study aimed to compare 2 quantitative acoustic measures of nasality in children with cleft lip and palate (CLP) and healthy controls using formalized perceptual assessment as a guide. METHOD: Fifty participants (23 children with CLP and 27 age- and gender-matched healthy controls) aged between 4 and 12 years produced a variety of high […]

A Comparison of Four Computerized Neurocognitive Assessment Tools to a Traditional Neuropsychological Test Battery in Service Members with and without Mild Traumatic Brain Injury.

Authors: Arrieux JP, Cole WR, Ivins BJ, Qashu FM, Schwab KA

Journal: Archives of Clinical Neuropsychology

DOI: 10.1093/arclin/acx036

Year Published: 2017

Objective: Computerized neurocognitive assessment tools (NCATS) are often used as a screening tool to identify cognitive deficits after mild traumatic brain injury (mTBI). However, differing methodology across studies renders it difficult to identify a consensus regarding the validity of NCATs. Thus, studies where multiple NCATs are administered in the same sample using the same methodology […]

A comparison of the CogState Schizophrenia Battery and the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) Battery in assessing cognitive impairment in chronic schizophrenia.

Authors: Maruff P, Norman T, Olver J, Pietrzak RH, Piskulić D, Snyder PJ

Journal: Journal of Clinical and Experimental Neuropsychology

DOI: 10.1080/13803390802592458

Year Published: 2009

This study examined the criterion and construct validity of a brief computerized cognitive test battery (CogState Schizophrenia Battery) compared to a conventional cognitive test battery recommended by the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) consensus. The CogState and MATRICS batteries yielded comparable effect sizes in comparing patients with schizophrenia to healthy […]

A Cross-Sectional Analysis of Students’ Intuitions When Interpreting CIs.

Authors: Cumming G, Kalinowski P, Lai J

Journal: Frontiers in Psychology

DOI: 10.3389/fpsyg.2018.00112

Year Published: 2018

We explored how students interpret the relative likelihood of capturing a population parameter at various points of a CI in two studies. First, an online survey of 101 students found that students’ beliefs about the probability curve within a CI take a variety of shapes, and that in fixed choice tasks, 39% CI [30, 48] […]

A cross-sectional study to evaluate the association of hyperbilirubinaemia on markers of cardiovascular disease, neurocognitive function, bone mineral density and renal markers in HIV-1 infected subjects on protease inhibitors.

Authors: Asboe D, Barber TJ, Boffito M, Hill A, Jagjit Singh G, Moyle G, Nelson M, Scourfield A, Waters L, Yapa HM

Journal: HIV Clinical Trials

DOI: 10.1080/15284336.2016.1176305

Year Published: 2016

BACKGROUND: Ongoing inflammation in controlled HIV infection contributes to non-AIDS comorbidities. High bilirubin appears to exhibit an anti-inflammatory effect in vivo. We therefore examined whether increased bilirubin in persons with HIV was associated with differences in markers of inflammation and cardiovascular, bone, renal disease, and neurocognitive (NC) impairment. METHODS: This cross-sectional study examined inflammatory markers […]

A Newly Designed Mobile-Based Computerized Cognitive Addiction Therapy App for the Improvement of Cognition Impairments and Risk Decision Making in Methamphetamine Use Disorder: Randomized Controlled Trial.

Authors: Chen T, Du J, Jiang H, Li R, Li X, Su H, Tan H, Xu D, Yan H, Zhao M., Zhong N, Zhu Y

Journal: JMIR mHealth and uHealth

DOI: 10.2196/10292

Year Published: 2018

BACKGROUND: Cognitive rehabilitation therapy has been found to improve cognitive deficits and impulse control problems in methamphetamine use disorder (MUD). However, there is limited research regarding this therapy’s feasibility when using mobile-based health technologies in supporting recovery from MUD in China. OBJECTIVE: The main aim of this study was to test whether 4 weeks of […]

A phase 2, double-blind, placebo-controlled study of NSI-189 phosphate, a neurogenic compound, among outpatients with major depressive disorder.

Authors: Drouillard A, Fava M, Flynn M, Hand H, Hoeppner B, Johe K, Kashambwa R, Kay G, Martinson MA, Papakostas GI, Russo P, Yeung A

Journal: Molecular Psychiatry

DOI: 10.1038/s41380-018-0334-8

Year Published: 2019

NSI-189 is a novel neurogenic compound independent of monoamine reuptake pathways. This trial evaluated oral NSI-189 as monotherapy in major depressive disorder. To improve signal detection, the sequential-parallel comparison design (SPCD) was chosen. Two hundred and twenty subjects were randomized to NSI-189 40 mg daily, 80 mg daily, or placebo for 12 weeks. The primary outcome measure […]

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A Phase II study of a histamine H3 receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy.

Authors: Ball MP, Breier A, Buchanan RW, Carter CS, Csernansky JG, Goff DC, Green MF, Grove RA, Horrigan JP, Jarskog LF, Kantrowitz JT, Keefe RS, Keshavan MS, Laurelle M, Lieberman JA, Lowy MT, Marder SR, Maruff P, McMahon RP, Peykamian MA, Seidman LJ

Journal: Schizophrenia Research

DOI: 10.1016/j.schres.2015.01.041.

Year Published: 2015

This Phase II exploratory study assessed GSK239512, a brain penetrant histamine H3 receptor antagonist, versus placebo on cognitive impairment in 50 stable outpatients with schizophrenia. Subjects were randomized to placebo or GSK239512 for 7weeks (4weeks titration). GSK239512 was associated with a small positive effect size (ES) on the CogState Schizophrenia Battery (CSSB) Composite Score (ES=0.29, […]

A pilot evaluation of a computer-based psychometric test battery designed to detect impairment in patients with cirrhosis.

Authors: Cook NA, Crossey MM, Harel BT, Kim JU, Kimhofer T, Pasha Y, Schembri AJ, Taylor-Robinson SD

Journal: International Journal of General Medicine

DOI: 10.2147/IJGM.S140197

Year Published: 2017

BACKGROUND: Psychometric testing is used to identify patients with cirrhosis who have developed hepatic encephalopathy (HE). Most batteries consist of a series of paper-and-pencil tests, which are cumbersome for most clinicians. A modern, easy-to-use, computer-based battery would be a helpful clinical tool, given that in its minimal form, HE has an impact on both patients’ […]

A pilot study of the neuropsychological benefits of computerized cognitive rehabilitation in Ugandan children with HIV.

Authors: Bangirana P, Boivin MJ, Busman RA, Giordani B, Opoka RO, Page CF, Parikh SM

Journal: Neuropsychology

DOI: 10.1037/a0019312

Year Published: 2010

OBJECTIVE: Because antiretroviral treatment (ART) fails to improve neurocognitive impairment in children with HIV, we completed a pilot study evaluating the feasibility and cognitive benefit of computerized cognitive rehabilitation therapy (CCRT) in Ugandan children with HIV. METHOD: Sixty Ugandan children with HIV (23 on ART) were randomly assigned to 10 sessions of Captain’s Log CCRT […]

A Placebo-Controlled Trial of AQW051 in Patients With Moderate to Severe Levodopa-Induced Dyskinesia.

Authors: Azulay JP, Berg D, Broussolle E, Ceballos-Baumann A, Corvol JC, Defebvre L, Derkinderen P, Di Paolo T, Durif F, Eggert K, Espay AJ, Feigin A, Feuerbach D, Geny C, Gomez-Mancilla B, Gostkowski M, Hockey HU, Houeto JL, Jaeger J, Jakab A, Johns D, Linazasoro G, Maruff P, Rascol O, Rozenberg I, Schwarz J, Sovago J, Stocchi F, Storch A, Tranchant C, Trenkwalder C, Weiss M, Zhang L

Journal: Movement Disorders

DOI: 10.1002/mds.26569.

Year Published: 2016

BACKGROUND: This phase 2 randomized, double-blind, placebo-controlled study evaluated the efficacy and safety of the nicotinic acetylcholine receptor α7 agonist AQW051 in patients with Parkinson’s disease and levodopa-induced dyskinesia. METHODS: Patients with idiopathic Parkinson’s disease and moderate to severe levodopa-induced dyskinesia were randomized to AQW051 10 mg (n = 24), AQW051 50 mg (n = […]

A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer’s Disease.

Authors: Ames D, Burnham SC, Groth D, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Milicic L, Peretti M, Porter T, Rainey-Smith S, Rowe CC, Salvado O, Savage G, Taddei K, Verdile G, Villemagne VL

Journal: Frontiers in Aging Neuroscience

DOI: 10.3389/fnagi.2018.00423

Year Published: 2018

Studies of Alzheimer’s disease risk-weighted polygenic risk scores (PRSs) for cognitive performance have reported inconsistent associations. This inconsistency is particularly evident when PRSs are assessed independent of APOE genotype. As such, the development and assessment of phenotype-specific weightings to derive PRSs for cognitive decline in preclinical AD is warranted. To this end a episodic memory-weighted […]

A proof-of-concept, randomized controlled trial of DAR-0100A, a dopamine-1 receptor agonist, for cognitive enhancement in schizophrenia.

Authors: Abi-Dargham A, Carter CS, Cho RY, Girgis RR, Glass A, Kegeles LS, Lieberman JA, Slifstein M, Thompson JL, Van Snellenberg JX, Wall M

Journal: Journal of Psychopharmacology

Year Published: 2016

BACKGROUND: Evidence from preclinical and human studies indicates the presence of reduced dopamine-1 receptor (D1R) signaling in the cortex, where D1Rs predominate, in patients with schizophrenia (SCZ), which may contribute to their cognitive deficits. Furthermore, studies in nonhuman primates (NHP) have suggested that intermittent administration of low doses of D1R agonists produce long-lasting reversals in […]