Access hundreds of peer-reviewed cognitive research papers published by leading neuroscientists using Cogstate technology.


The impact of chemotherapy on cognitive function: a multicentre prospective cohort study in testicular cancer.

Authors: Davis ID, Grimison P, Kalinowski P, Martin A, Maruff P, Olver IN, Schembri A, Stockler M, Toner GC, Whitford HS

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

DOI: 10.1007/s00520-019-05095-3

Year Published: 2019

PURPOSE: The causal link between chemotherapy and cognitive impairment is unclear. We studied testicular cancer patients’ objective and subjective cognitive function longitudinally, comparing a surgery group with a surgery + chemotherapy group, addressing prior methodological issues using a computerized test to limit assessment issues, and controlling for confounding variables. METHODS: Prospectively, of 145 patients from […]

Resistance training enhances delayed memory in healthy middle-aged and older adults: A randomised controlled trial.

Authors: Brown BM, Gordon N, Laws SM, Marston KJ, Martins RN, Peiffer JJ, Rainey-Smith SR, Sohrabi HR, Teo SY

Journal: Journal of Science and Medicine in Sport / Sports Medicine Australia

DOI: 10.1016/j.jsams.2019.06.013

Year Published: 2019

OBJECTIVES: High-intensity exercise is a potential therapeutic tool to postpone or prevent the onset of cognitive decline. However, there is a lack of sufficient evidence regarding the longitudinal effects of structured resistance training on cognitive function in healthy adults. The purpose of this study was to investigate the effect of two ecologically valid, intense 12-week […]

Migraine comorbidity and cognitive performance in patients with focal epilepsy.

Authors: Begasse de Dhaem OAJ, Cristofaro S, French J, Hesdorffer DC, Meador KJ, Minen MT, Morrison C

Journal: Epilepsy & behavior : E&B

DOI: 10.1016/j.yebeh.2019.05.008

Year Published: 2019

BACKGROUND: Migraine and epilepsy are comorbid conditions. While it is well known that epilepsy can have an impact on cognitive abilities, there is conflicting evidence in the literature on the relationship between migraine and cognitive function. The aim of this study was to assess whether migraine comorbidity in patients with newly diagnosed focal epilepsy is […]

Depression, lifestyle factors and cognitive function in people living with HIV and comparable HIV-negative controls.

Authors: Anderson J, Bagkeris E, Boffito M, De Francesco D, Johnson M, Mallon P, Post FA, Sabin CA, Underwood J, Vera JH, Williams I, Winston A

Journal: HIV Medicine

DOI: 10.1111/hiv.12714

Year Published: 2019

OBJECTIVES: We investigated whether differences in cognitive performance between people living with HIV (PLWH) and comparable HIV-negative people were mediated or moderated by depressive symptoms and lifestyle factors. METHODS: A cross-sectional study of 637 ‘older’ PLWH aged ≥ 50 years, 340 ‘younger’ PLWH aged < 50 years and 276 demographically matched HIV-negative controls aged ≥ […]

Cognition in breast cancer survivors: A pilot study of interval and continuous exercise.

Authors: Ikin A, Northey JM, Pumpa KL, Quinlan C, Rattray B, Smee DJ, Toohey K

Journal: Journal of Science and Medicine in Sport / Sports Medicine Australia

DOI: 10.1016/j.jsams.2018.11.026

Year Published: 2019

OBJECTIVES: The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors. DESIGN: Pilot randomised-controlled trial. METHODS: Seventeen female cancer survivors (mean: 62.9±7.8years) were randomised into three groups: high-intensity interval training (HIIT, n=6); moderate-intensity continuous training (MOD, n=5); or wait-list control (CON, n=6). The HIIT and MOD groups exercised […]

A Research of Methamphetamine Induced Psychosis in 1,430 Individuals With Methamphetamine Use Disorder: Clinical Features and Possible Risk Factors.

Authors: Chen T, Du J, Gan H, Jiang H, Tan H, Zhao M., Zhao Y, Zhong N, Zhu Y

Journal: Frontiers in psychiatry

DOI: 10.3389/fpsyt.2018.00551

Year Published: 2018

Background and Aims: Methamphetamine (MA) abuse is commonly associated with the development of psychotic symptoms. The predictors and related risk factors of MA induced psychosis (MIP) are poorly understood. We investigated the occurrence of MIP, and analyzed the clinical features and possible risk factors among individuals with MA use disorder. Method: One thousand four hundred […]

A Newly Designed Mobile-Based Computerized Cognitive Addiction Therapy App for the Improvement of Cognition Impairments and Risk Decision Making in Methamphetamine Use Disorder: Randomized Controlled Trial.

Authors: Chen T, Du J, Jiang H, Li R, Li X, Su H, Tan H, Xu D, Yan H, Zhao M., Zhong N, Zhu Y

Journal: JMIR mHealth and uHealth

DOI: 10.2196/10292

Year Published: 2018

BACKGROUND: Cognitive rehabilitation therapy has been found to improve cognitive deficits and impulse control problems in methamphetamine use disorder (MUD). However, there is limited research regarding this therapy’s feasibility when using mobile-based health technologies in supporting recovery from MUD in China. OBJECTIVE: The main aim of this study was to test whether 4 weeks of […]

Similar psychotic and cognitive profile between ketamine dependence with persistent psychosis and schizophrenia.

Authors: Chen CH, Chen CK, Cheng WJ, Huang MC, Krystal JH, Pietrzak RH, Xu K

Journal: Schizophrenia Research

DOI: 10.1016/j.schres.2018.02.049

Year Published: 2018

BACKGROUND: Ketamine has been used to probe the biology of psychosis and cognitive dysfunction in humans. High levels of ketamine abuse are associated with persisting psychosis (KPP) in a minority of users. However, relatively little is known about cognitive function among KPP patients and whether the cognitive impairments associated with KPP resemble those of schizophrenia […]

The association of total cholesterol with processing speed is moderated by age in mid- to late-age healthy adults.

Authors: Beeri MS, Dayman V, Elkana O, Franko M, Israel A, Segev S, Springer RR

Journal: Experimental Aging Research

DOI: 10.1080/0361073X.2017.1422585

Year Published: 2018

OBJECTIVES: To investigate the nature of the association of normal levels of total cholesterol with cognitive function and the contribution of age to this association. METHODS: A sample of 61 senior executives, who were summoned for an annual medical examination with approximately four measurements of total cholesterol during 4 years, were examined with a computerized […]

Water intake reverses dehydration associated impaired executive function in healthy young women.

Authors: Freese E, Harkness L, Leone CA, Mitchell ES, Stachenfeld NS

Journal: Physiology and Behavior

DOI: 10.1016/j.physbeh.2017.12.028

Year Published: 2018

Introduction Healthy women do not always consume Recommended Daily Levels of fluid intake ad libitum. We hypothesized that 1) women lose ≥ 1.0% BW during daily activities, 2) that mild body water loss impairs memory and executive function, 3) water intake to recommended daily levels will improve cognitive function. Methods We tested 12 women (26 […]

Reliability of Computerized Neurocognitive Tests for Concussion Assessment: A Meta-Analysis.

Authors: Dargo L, Farnsworth JL 2nd, Kang M, Ragan BG

Journal: Journal of Athletic Training

DOI: 10.4085/1062-6050-52.6.03

Year Published: 2017

OBJECTIVE: Although widely used, computerized neurocognitive tests (CNTs) have been criticized because of low reliability and poor sensitivity. A systematic review was published summarizing the reliability of Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT) scores; however, this was limited to a single CNT. Expansion of the previous review to include additional CNTs and a meta-analysis […]

Brain Network Activation Technology Does Not Assist with Concussion Diagnosis and Return to Play in Football Athletes.

Authors: Broglio SP, Eckner JT, Lapointe A, Meehan SK, Moore B, Rettmann A, Williams R

Journal: Frontiers in Neurology

DOI: 10.3389/fneur.2017.00252

Year Published: 2017

BACKGROUND: Concussion diagnosis and management remains a largely subjective process. This investigation sought to evaluate the utility of a novel neuroelectric measure for concussion diagnosis and return to play decision-making. HYPOTHESIS: Brain Network Activation (BNA) scores obtained within 72-h of injury will be lower than the athlete’s preseason evaluation and that of a matched control […]

The effects of an extensive exercise programme on the progression of Mild Cognitive Impairment (MCI): study protocol for a randomised controlled trial.

Authors: Devenney KE, Lawlor B, Olde Rikkert MGM, Sanders ML, Schneider S

Journal: BMC Geriatrics

DOI: 10.1186/s12877-017-0457-9

Year Published: 2017

BACKGROUND: Exercise interventions to prevent dementia and delay cognitive decline have gained considerable attention in recent years. Human and animal studies have demonstrated that regular physical activity targets brain function by increasing cognitive reserve. There is also evidence of structural changes caused by exercise in preventing or delaying the genesis of neurodegeneration. Although initial studies […]

Posttraumatic stress disorder symptoms and cognitive function in a large cohort of middle-aged women.

Authors: Grodstein F, Hagan K, Harel B, Koenen KC, Roberts AL, Sumner JA

Journal: Depression and Anxiety

DOI: 10.1002/da.22600

Year Published: 2017

BACKGROUND: Posttraumatic stress disorder (PTSD) has been linked to cognitive decline, but research in women is generally lacking. We examined whether trauma and elevated PTSD symptoms were associated with worse cognitive function in middle-aged civilian women. A secondary objective was to investigate the possible role of depression in the relation of PTSD symptoms to cognitive […]

Do Wellness Tourists Get Well? An Observational Study of Multiple Dimensions of Health and Well-Being After a Week-Long Retreat.

Authors: Cohen MM, Elliott F, Mantri N, Oates L, Schembri A

Journal: Journal of Alternative and Complementary Medicine

DOI: 10.1089/acm.2016.0268

Year Published: 2017

BACKGROUND: Wellness retreats use many complementary and alternative therapies within a holistic residential setting, yet few studies have evaluated the effect of retreat experiences on multiple dimensions of health and well-being, and no published studies have reported health outcomes in wellness tourists. OBJECTIVES: To assess the effect of a week-long wellness-retreat experience in wellness tourists. […]

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Use of an experimental language acquisition paradigm for standardized neuropsychological assessment of learning: A pilot study in young and older adults.

Authors: Baker JE, Bruns L Jr, Hassenstab J, Lim YY, Maruff P, Masters CL

Journal: Journal of Clinical and Experimental Neuropsychology

DOI: 10.1080/13803395.2019.1665626

Year Published: 2020

Introduction: Despite the numerous episodic memory tasks used in neuropsychological assessment, relatively few learning tasks are available, with methods lacking the complexity and sophistication to capture very subtle changes in information acquisition. Method: We adapted a previously validated associative learning task for use within an online framework, utilizing real-world stimuli, in which learning of audio-visual […]

Hippocampal segmentation for brains with extensive atrophy using three-dimensional convolutional neural networks.

Authors: Adamo S, Akhavein H, Black SE, Gao F, Goubran M, Holmes M, MacIntosh B, Martel A, Masellis M, Nestor S, Ntiri EE, Ozzoude M, Ramirez J, Scott C, Swardfager W, Swartz R

Journal: Human brain mapping

DOI: 10.1002/hbm.24811

Year Published: 2020

Hippocampal volumetry is a critical biomarker of aging and dementia, and it is widely used as a predictor of cognitive performance; however, automated hippocampal segmentation methods are limited because the algorithms are (a) not publicly available, (b) subject to error with significant brain atrophy, cerebrovascular disease and lesions, and/or (c) computationally expensive or require parameter […]

Identification of Pre-Clinical Alzheimer’s Disease in a Population of Elderly Cognitively Normal Participants.

Authors: Doecke JD, Maruff P, Mengersen K, Rousseau J, van Havre Z, Villemagne VL, White N

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191095

Year Published: 2020

Alzheimer’s disease (AD) has a long pathological process, with an approximate lead-time of 20 years. During the early stages of the disease process, little evidence of the building pathology is identifiable without cerebrospinal fluid and/or imaging analyses. Clinical manifestations of AD do not present until irreversible pathological changes have occurred. Given an opportunity to provide […]

The Effect of Hearing Aid Use on Cognition in Older Adults: Can We Delay Decline or Even Improve Cognitive Function?

Authors: Busby P, Harris D, Launer S, Lemke U, Maruff P, Sarant J, Schembri A

Journal: Journal of clinical medicine

DOI: 10.3390/jcm9010254

Year Published: 2020

Hearing loss is a modifiable risk factor for dementia in older adults. Whether hearing aid use can delay the onset of cognitive decline is unknown. Participants in this study (aged 62-82 years) were assessed before and 18 months after hearing aid fitting on hearing, cognitive function, speech perception, quality of life, physical activity, loneliness, isolation, […]

Associations of Apolipoprotein E ε4 Genotype and Ball Heading With Verbal Memory in Amateur Soccer Players.

Authors: Davies P, Freudenberg-Hua Y, Hu S, Hunter LE, Kim M, Lipton ML, Lipton RB, Srinivasan P, Stewart WF

Journal: JAMA Neurology

DOI: 10.1001/jamaneurol.2019.4828

Year Published: 2020

Importance: Emerging evidence suggests that long-term exposure to ball heading in soccer, the most popular sport in the world, confers risk for adverse cognitive outcomes. However, the extent to which the apolipoprotein E ε4 (APOE ε4) allele, a common risk factor for neurodegeneration, and ball heading are associated with cognition in soccer players remains unknown. […]


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Rates of age- and amyloid β-associated cortical atrophy in older adults with superior memory performance.

Authors: Ames D, Dang C, Doecke JD, Fripp J, Harrington KD, Hickey M, Laws SM, Lim YY, Maruff P, Masters CL, Rainey-Smith S, Rowe CC, Salvado O, Snyder PJ, Sohrabi HR, Villemagne VL, Weinborn M, Xia Y, Yassi N

Journal: Alzheimer's & dementia : diagnosis assessment & disease monitoring

DOI: 10.1016/j.dadm.2019.05.005

Year Published: 2019

Introduction: Superior cognitive performance in older adults may reflect underlying resistance to age-associated neurodegeneration. While elevated amyloid β (Aβ) deposition (Aβ+) has been associated with increased cortical atrophy, it remains unknown whether “SuperAgers” may be protected from Aβ-associated neurodegeneration. Methods: Neuropsychologically defined SuperAgers (n = 172) and cognitively normal for age (n = 172) older […]

SuperAging: Current findings yield future challenges-A response to Rogalski and Goldberg.

Authors: Dang C, Maruff P

Journal: Alzheimer's & dementia : diagnosis assessment & disease monitoring

DOI: 10.1016/j.dadm.2019.05.004

Year Published: 2019


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Influence of Comorbidity of Cerebrovascular Disease and Amyloid-β on Alzheimer’s Disease.

Authors: Ames D, Chen C, Desmond PM, Fowler C, Hilal S, Kuijf H, Lim YY, Martins R, Maruff P, Masters CL, Rowe C, Salvado O, Villemagne V, Watson R, Xia Y, Yassi N, Yates P

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191028

Year Published: 2019

BACKGROUND: Quantifying the contribution of cerebrovascular disease to the clinical and pathological profile of Alzheimer’s disease is challenging. OBJECTIVE: We aimed to determine the influence of cerebrovascular disease, amyloid-β (Aβ), and their comorbidity on cognitive decline, hippocampal atrophy, and Aβ deposition, by evaluating data from the Australian Imaging, Biomarker and Lifestyle Study of Ageing. METHODS: […]

Identification of Pre-Clinical Alzheimer’s Disease in a Population of Elderly Cognitively Normal Participants.

Authors: Doecke JD, Maruff P, Mengersen K, Rousseau J, van Havre Z, Villemagne V, White N

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-191095

Year Published: 2019

Alzheimer’s disease (AD) has a long pathological process, with an approximate lead-time of 20 years. During the early stages of the disease process, little evidence of the building pathology is identifiable without cerebrospinal fluid and/or imaging analyses. Clinical manifestations of AD do not present until irreversible pathological changes have occurred. Given an opportunity to provide […]

C-reactive protein and response to lurasidone treatment in children and adolescents with bipolar I depression: Results from a placebo-controlled trial.

Authors: Loebel A, Pikalov A, Raison CL, Siu C, Tocco M

Journal: Brain behavior and immunity

DOI: 10.1016/j.bbi.2019.12.010

Year Published: 2019

This study sought to investigate associations between levels of high-sensitivity c-reactive protein (hsCRP) prior to treatment and change in depressive symptoms and cognition in a short-term, double-blind, placebo-controlled study of lurasidone in children and adolescents with bipolar I depression. Patients 10-17 years of age with a DSM-5 diagnosis of bipolar I depression were randomized to […]


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Neuropsychological Trajectories Associated with Adolescent Alcohol and Cannabis Use: A Prospective 14-Year Study.

Authors: Coronado C, Courtney KE, Infante MA, Jacobus J, Nguyen-Louie TT, Worley M

Journal: Journal of the International Neuropsychological Society : JINS

DOI: 10.1017/S1355617719001395

Year Published: 2019

OBJECTIVES: Alcohol and cannabis remain the substances most widely used by adolescents. Better understanding of the dynamic relationship between trajectories of substance use in relation to neuropsychological functioning is needed. The aim of this study was to examine the different impacts of within- and between-person changes in alcohol and cannabis use on neuropsychological functioning over […]

Effects of transcranial direct current stimulation on cognition and symptoms in Chinese patients with schizophrenia✰.

Authors: Davis JM, Faull R, Jiang J, Jin H, Li C, Md WL, Smith RC, Szabo V, Wang J, Wang Y

Journal: Psychiatry Research

DOI: 10.1016/j.psychres.2019.112617

Year Published: 2019

There is preliminary evidence that transcranial direct current stimulation(tDCS) may improve symptoms and cognitive function in schizophrenia, but the generalizability of these results needs further investigation. We present a study of the effects of active vs. sham tDCS on cognition and symptoms in a sample of 45 Chinese patients with schizophrenia who showed significant cognitive […]

Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD.

Authors: Amariglio RE, Buckley R, Johnson KA, Maruff P, Masters CL, Mormino E, Papp KV, Rentz DM, Sperling RA, Villemagne VL

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2019.09.074

Year Published: 2019

INTRODUCTION: Demonstrating the “clinical meaningfulness” of slowing early cognitive decline in clinically normal (CN) older adults with elevated amyloid-β (Aβ+) is critical for Alzheimer’s disease secondary prevention trials and for understanding early cognitive progression. METHODS: Cox regression analyses were used to determine whether 3-year slopes on the preclinical Alzheimer’s cognitive composite predicted MCI diagnosis and […]

Computerized cognitive performance assessments in the Brooklyn Cognitive Impairments in Health Disparities Pilot Study.

Authors: Adler K, Apple S, Cheng F, Cohen C, Friedlander A, Gustafson D, Levine SR, Lucchesi M, Maruff P, Reinhardt M, Salmieri M, Stevens D, Weingast S

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2019.07.004

Year Published: 2019

INTRODUCTION: Detecting cognitive impairment in diverse, health disparities communities is an urgent health care priority. METHODS: The Brooklyn Cognitive Impairments in Health Disparities Pilot Study investigated quantitative aspects and liking of a computerized cognitive performance assessment, Cognigram, among individuals ≥ 40 years in traditional and nontraditional primary care settings. RESULTS: Cognigram was piloted in the […]

Health-related quality of life, emotional burden, and neurocognitive function in the first generation of metastatic melanoma survivors treated with pembrolizumab: a longitudinal pilot study.

Authors: Awada G, De Cremer J, De Ridder M, Leys C, Neyns B, Rogiers A, Schembri A, Theuns P

Journal: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

DOI: 10.1007/s00520-019-05168-3

Year Published: 2019

PURPOSE: The aim of this study was to assess the evolution of health-related quality of Life (HRQoL), emotional burden, and neurocognitive function in the first-generation metastatic melanoma survivors treated with pembrolizumab. METHODS: Survivors were defined as patients who achieved a durable remission for at least 6 months after initiating pembrolizumab in a single-center observational study […]