Cognitive deficits

Memantine for Prevention of Cognitive Late Effects in Children and Adolescents Receiving Radiation Therapy for Brain Tumors: A Randomized, Controlled, Pilot Trial

Authors: Heather M Conklin, Raja B Khan, Jason M Ashford, Christina Owens, Andrea Simmons, Christina Bosley, Chia-Wei Hsu, Haitao Pan, Amar Gajjar, Thomas E Merchant

Journal: International Journal of Radiation Oncology Biology Physics

Year Published: 2026

Purpose: Children receiving irradiation for brain tumors are at significant risk for cognitive deficits that notably impact quality of life. This is the first randomized, controlled investigation of the feasibility, acceptability, and preliminary efficacy of memantine […]

Preliminary evidence concerning the pattern and magnitude of cognitive dysfunction in major depressive disorder using cogstate measures

Authors: Margaret T Davis, Nicole DellaGioia, David Matuskey, Brian Harel, Paul Maruff, Robert H Pietrzak, Irina Esterlis

Journal: Journal of Affective Disorders

Year Published: 2017

Background: Cognitive deficits are common in individuals with major depressive disorder (MDD), and are associated with treatment non-responsiveness and poorer functional outcomes. Characterization of the nature and magnitude of deficits in this population has been limited […]

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