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The Effect of Cochlear Implants on Cognitive Function in Older Adults: Initial Baseline and 18-Month Follow Up Results for a Prospective International Longitudinal Study.

Authors: Briggs R, Busby P, Dowell R, Harris D, Maruff P, Sarant J, Schembri A

Journal: Frontiers in neuroscience

DOI: 10.3389/fnins.2019.00789

Year Published: 2019

In older adults, hearing loss is independently associated with an increased rate of cognitive decline, and has been identified to be a modifiable risk factor for dementia. The mechanism underlying the cognitive decline associated with hearing loss is not understood, but it is known that the greater the hearing loss, the faster the rate of […]

COMT val158met is not associated with Aβ-amyloid and APOE ε4 related cognitive decline in cognitively normal older adults.

Authors: Ames D, Burnham SC, Groth D, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Milicic L, Peretti M, Porter T, Rainey-Smith S, Rowe CC, Salvado O, Savage G, Sohrabi HR, Verdile G, Villemagne VL, Weinborn M

Journal: IBRO reports

DOI: 10.1016/j.ibror.2019.05.001

Year Published: 2019

The non-synonymous single nucleotide polymorphism (SNP), Val158Met within the Catechol-O-methyltransferase (COMT) gene has been associated with altered levels of cognition and memory performance in cognitively normal adults. This study aimed to investigate the independent and interactional effects of COMT Val158Met on cognitive performance. In particular, it was hypothesised that COMT Val158Met would modify the effect […]

Sensitivity of a Preclinical Alzheimer’s Cognitive Composite (PACC) to amyloid β load in preclinical Alzheimer’s disease.

Authors: Ames D, Bransby L, Fowler C, Harrington K, Lim YY, Maruff P, Masters CL, Roberston J, Salvado O, Snyder PJ, Villemagne VL

Journal: Journal of Clinical and Experimental Neuropsychology

DOI: 10.1080/13803395.2019.1593949

Year Published: 2019

Introduction: Preclinical Alzheimer’s disease (AD) is characterized by amyloid-related cognitive decline. Reduction in this decline is used to determine the efficacy of drug therapies designed to forestall the disease in preclinical AD clinical trials, measured by a Preclinical Alzheimer’s Cognitive Composite (PACC). Most studies estimate rates of cognitive change by comparing cognitively normal (CN) older […]

A Polygenic Risk Score Derived From Episodic Memory Weighted Genetic Variants Is Associated With Cognitive Decline in Preclinical Alzheimer’s Disease.

Authors: Ames D, Burnham SC, Groth D, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Milicic L, Peretti M, Porter T, Rainey-Smith S, Rowe CC, Salvado O, Savage G, Taddei K, Verdile G, Villemagne VL

Journal: Frontiers in Aging Neuroscience

DOI: 10.3389/fnagi.2018.00423

Year Published: 2018

Studies of Alzheimer’s disease risk-weighted polygenic risk scores (PRSs) for cognitive performance have reported inconsistent associations. This inconsistency is particularly evident when PRSs are assessed independent of APOE genotype. As such, the development and assessment of phenotype-specific weightings to derive PRSs for cognitive decline in preclinical AD is warranted. To this end a episodic memory-weighted […]

Utility of an Alzheimer’s Disease Risk-Weighted Polygenic Risk Score for Predicting Rates of Cognitive Decline in Preclinical Alzheimer’s Disease: A Prospective Longitudinal Study.

Authors: Ames D, Burnham SC, Groth D, Laws SM, Li QX, Lim YY, Maruff P, Masters CL, Milicic L, Porter T, Rainey-Smith S, Rowe CC, Salvado O, Savage G, Verdile G, Villemagne VL

Journal: Journal of Alzheimer's Disease

DOI: 10.3233/JAD-180713

Year Published: 2018

BACKGROUND: With the exception of APOE, genetic variants associated with increased Alzheimer’s disease (AD) risk are characterized by small effect sizes. Polygenic risk scores (PRS) have shown utility in predicting AD risk; however, their utility for predicting decline in cognition at preclinical stages of AD is poorly understood. OBJECTIVE: To validate associations of a 22-variant […]

Online study partner-reported cognitive decline in the Brain Health Registry.

Authors: Camacho MR, Finley S, Flenniken D, Fockler J, Insel PS, Mackin RS, Maruff P, Nosheny RL, Truran D, Ulbricht A, Weiner MW, Yaffe K

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.trci.2018.09.008

Year Published: 2018

Introduction: Methods for efficiently identifying cognitive decline and Alzheimer’s disease (AD) are a critical unmet need. The goal of this work was to validate novel online study partner (SP)-reported outcomes to identify cognitive decline in older adults. Methods: In older adults enrolled in the Brain Health Registry, we analyzed associations between SP-reported cognitive decline, measured […]

Episodic Memory and Learning Dysfunction Over an 18-Month Period in Preclinical and Prodromal Alzheimer’s Disease.

Authors: Ames D, Baker JE, Jaeger J, Lautenschlager NT, Lim YY, Maruff P, Masters CL, Pietrzak RH, Robertson J, Rowe CC, Snyder PJ, Villemagne VL

Journal: Journal of Alzheimer's disease : JAD

DOI: 10.3233/JAD-180344

Year Published: 2018

Recent meta-analyses suggest that episodic memory impairment associated with preclinical Alzheimer’s disease (AD) equates to 0.15-0.24 standard deviations below that of cognitively healthy older adults. The current study aimed to characterize impairments in verbal acquisition and recall detectable at a single assessment, and investigate how verbal learning and episodic memory deteriorates in preclinical AD. A […]

Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer’s disease: Findings from three well-characterized cohorts.

Authors: Amariglio RE, Buckley RF, Burnham S, Chhatwal J, Dobson A, Donohue MC, Dore V, Hanseeuw BJ, Hedden T, Jacobs HIL, Johnson KA, Kirn D, Lim YY, Maruff P, Masters CL, Mormino EC, Papp KV, Properzi MJ, Rabin JS, Rentz DM, Rowe CC, Schultz AP, Sperling RA, Villemagne VL, Waller M

Journal: Alzheimer's and Dementia

DOI: 10.1016/j.jalz.2018.04.010

Year Published: 2018

INTRODUCTION: Our objective was to investigate the effect of sex on cognitive decline within the context of amyloid β (Aβ) burden and apolipoprotein E genotype. METHODS: We analyzed sex-specific effects on Aβ-positron emission tomography, apolipoprotein, and rates of change on the Preclinical Alzheimer Cognitive Composite-5 across three cohorts, such as the Alzheimer’s Disease Neuroimaging Initiative, […]

Indication of Cognitive Change and Associated Risk Factor after Thoracic Surgery in the Elderly: A Pilot Study.

Authors: Hoshikawa Y, Kawashima R, Kulason K, Noda M, Nouchi R, Okada Y

Journal: Frontiers in Aging Neuroscience

DOI: 10.3389/fnagi.2017.00396

Year Published: 2018

Background: This pilot study investigated the effects of partial pulmonary lobectomy lung surgery on cognitive functions of elderly Japanese patients. It is recognized that elderly patients undergoing surgery have increased risk of Postoperative Cognitive Decline (POCD), a condition in which learning, memory, and processing speed is greatly reduced after surgery. Since elderly patients are more […]

Cerebral quantitative susceptibility mapping predicts amyloid-β-related cognitive decline.

Authors: Ames D, Ayton S, Bourgeat P, Bush AI, Desmond P, Diouf I, Doecke J, Farquharson S, Fazlollahi A, Fripp J, Lim YY, Maruff P, Masters CL, Ng A, Ordidge R, Raniga P, Rowe CC, Salvado O, Villemagne VL

Journal: Brain

DOI: 10.1093/brain/awx137

Year Published: 2017

See Derry and Kent (doi:10.1093/awx167) for a scientific commentary on this article.The large variance in cognitive deterioration in subjects who test positive for amyloid-β by positron emission tomography indicates that convergent pathologies, such as iron accumulation, might combine with amyloid-β to accelerate Alzheimer’s disease progression. Here, we applied quantitative susceptibility mapping, a relatively new magnetic […]

Sensitivity of composite scores to amyloid burden in preclinical Alzheimer’s disease: Introducing the Z-scores of Attention, Verbal fluency, and Episodic memory for Nondemented older adults composite score.

Authors: Ames D, Bourgeat P, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rowe CC, Salvado O, Snyder PJ, Ukiqi A, Villemagne VL

Journals: Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

DOI: 10.1016/j.dadm.2015.11.003

Year Published: 2016

INTRODUCTION: Cognitive composite scores developed for preclinical Alzheimer’s disease (AD) often consist of multiple cognitive domains as they may provide greater sensitivity to detect β-amyloid (Aβ)-related cognitive decline than episodic memory (EM) composite scores alone. However, this has never been empirically tested. We compared the rate of cognitive decline associated with high Aβ (Aβ+) and […]

APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer’s disease.

Authors: Ames D, Ellis KA, Harrington K, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rembach A, Rowe CC, Snyder PJ, Villemagne VL

Journal: Molecular Psychiatry

DOI: 10.1038/mp.2014.123

Year Published: 2014

Accumulation of β-amyloid (Aβ) in the brain is associated with memory decline in healthy individuals as a prelude to Alzheimer’s disease (AD). Genetic factors may moderate this decline. We examined the role of apolipoprotein E (ɛ4 carrier[ɛ4(+)], ɛ4 non-carrier[ɛ4(-)]) and brain-derived neurotrophic factor (BDNF(Val/Val), BDNF(Met)) in the extent to which they moderate Aβ-related memory decline. […]

Episodic memory decline predicts cortical amyloid status in community-dwelling older adults.

Authors: Brodtmann A, Darby DG, Fredrickson A, Fredrickson J, Maruff P, Pietrzak RH, Rowe C, Villemagne VL, Woodward M

Journal: Journal of Alzheimer's Disease

DOI: 10.3233/JAD-2011-110818

Year Published: 2011

Intra-individual decline in memory and cognition is characteristic of prodromal Alzheimer’s disease (AD) and may allow detection of very early AD pathology. Episodic memory task scores on a brief computerized cognitive battery (CogState) were prospectively evaluated at baseline, and 3-, 6-, 9-, 12-, and 24-months post-baseline. Linear mixed models were conducted to compute age-adjusted slopes. […]

Intraindividual cognitive decline using a brief computerized cognitive screening test.

Authors: Darby DG, Fredrickson A, Fredrickson J, Maruff P, Moore L, Pietrzak RH, Sach J, Woodward M

Journal: Alzheimer's & Dementia

DOI: 10.1016/j.jalz.2010.12.009

Year Published: 2012

BACKGROUND: Progressive intraindividual decline in memory and cognition is characteristic of dementia and may be useful in detecting very early Alzheimer’s disease pathology. METHODS: This study evaluated the slopes of cognitive performance over a 12-month period in 263 healthy, community-dwelling, adult volunteers aged ≥50 years. Participants completed a brief computerized battery of cognitive tests (CogState) […]