Cognitive aging

Amyloid β-associated cognitive decline in the absence of clinical disease progression and systemic illness.

Authors: Ames D, Dore V, Harrington KD, Hassenstab J, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Rainey-Smith S, Robertson J, Rowe CC, Salvado O, Snyder PJ, Villemagne VL

Journal: Alzheimer's & Dementia

INTRODUCTION: High levels of amyloid β (Aβ) are associated with cognitive decline in cognitively normal (CN) older adults. This study investigated the nature of cognitive decline in healthy individuals who did not progress to mild cognitive […]

Regular cognitive self-monitoring in community-dwelling older adults using an internet-based tool.

Authors: Andel R, Harrison Bush AL, Morgan D, Sadeq NA, Valdes EG

Journal: Journal of Clinical and Experimental Neuropsychology

INTRODUCTION: Monitoring for various health conditions (e.g., breast cancer, hypertension) has become common practice. However, there is still no established tool for regular monitoring of cognition. In this pilot longitudinal study, we examined the utility and […]

Influence of amyloid and apolipoprotein E on cognitive performance in a late middle-aged cohort.

Authors: Christianson TJ, Hagen CE, Jack CR Jr, Knopman DS, Kremers WK, Lowe VJ, Machulda MM, Mielke MM, Petersen RC, Roberts RO, Vemuri P

Journal: Alzheimer's & Dementia

INTRODUCTION: Few studies have examined the effects of amyloid and apolipoprotein E (APOE) genotype on cognition among middle-aged individuals. METHODS: We included 464 cognitively normal, test-naïve, participants with Pittsburgh compound B positron emission tomography amyloid imaging, […]

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