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Exercise effects on cognitive functioning in young adults with first-episode psychosis: FitForLife.

Authors: Ekblom Ö, Firth J, Forsell Y, Hallgren M, Schembri A, Skott M

Journal: Psychological Medicine

DOI: 10.1017/S0033291718001022

Year Published: 2018

BACKGROUND: Exercise has mood-enhancing effects and can improve cognitive functioning, but the effects in first-episode psychosis (FEP) remain understudied. We examined the feasibility and cognitive effects of exercise in FEP. METHOD: Multi-center, open-label intervention study. Ninety-one outpatients with FEP (mean age = 30 years, 65% male) received usual care plus a 12-week supervised circuit-training program, […]

Effect of Chlorogenic Acid Intake on Cognitive Function in the Elderly: A Pilot Study.

Authors: Kato M, Katsuragi Y, Kozuma K, Ochiai R, Sato H

Journal: Evidence-based complementary and alternative medicine

DOI: 10.1155/2018/8608497

Year Published: 2018

Objective: To evaluate the effect of chlorogenic acids (CGAs) intake on cognitive function. Methods: In this pilot study, the Cogstate and CNS Vital Signs test batteries were used to evaluate cognitive function in 8 healthy elderly men and women complaining of subjective memory loss after a 6-month intake of a test beverage containing 330 mg of […]

Impaired visual, working, and verbal memory in first-episode, drug-naive patients with major depressive disorder in a Chinese population.

Authors: Chen C, Gao CG, Hashimoto K, Jiang WH, Li Y, Ma XC, Wang W, Wu J

Journal: Public Library of Science One

Volume & Issue: 13 & 4

DOI: 10.1371/journal.pone.0196023

Year Published: 2018

Cognitive impairment has been observed in patients with major depressive disorder (MDD). However, it remains unclear whether the deficits in specific cognitive domains are present in first-episode, drug-naïve patients or medicated patients. In the present study, using the CogState battery (CSB) Chinese language version, we evaluated the visual, working, and verbal memory in first-episode drug-naive […]

Cognitive Function Before and After Left Heart Catheterization.

Authors: Evered L, MacIsaac A, Maher S, Maruff P, Scott DA, Silbert BS

Journal: Journal of the American Heart Association

Volume & Issue: 7 & 6

DOI: 10.1161/JAHA.117.008004

Year Published: 2018

BACKGROUND: Hospital procedures have been associated with cognitive change in older patients. This study aimed to document the prevalence of mild cognitive impairment in individuals undergoing left heart catheterization (LHC) before the procedure and the incidence of cognitive decline to 3 months afterwards. METHODS AND RESULTS: We conducted a prospective, observational, clinical investigation of elderly […]

Reverse and Forward Translational Neuropharmacology in Psychiatric Drug Discovery

Author: Christopher L. Shaffer

Journal: Clinical Pharmacology & Therapeutics

Volume & Issue: 103 & 2

Page No.: 193–195

DOI: 10.1002/cpt.901

Year Published: 2018

The probability of achieving marketing approval of a novel therapeutic for psychiatric indications is extremely low due largely to the inability to demonstrate durable and reproducible efficacy in phase II trials and beyond. These failures are often attributed to the lack of translation of the underlying neuropharmacology from animal model(s) to the disease population. However, […]

Effect of chlorogenic acid intake on cognitive function in the elderly: A pilot study

Authors: Hirotaka Sato, Kazuya Kozuma, Morimasa Kato, Ryuji Ochiai, Yoshihisa Katsuragi

Objective: To evaluate the effect of chlorogenic acids (CGAs) intake on cognitive function. Methods: In this pilot study, the Cogstate and CNS Vital Signs test batteries were used to evaluate cognitive function in 8 healthy elderly men and women complaining of subjective memory loss after a 6-month intake of a test beverage containing 330 mg […]

18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.

Authors: Berger M, Bisanar T, Borges-Neto S, Doraiswamy PM, James OG, Klinger RY, Li YJ, Mathew JP, Newman MF, Qi W, Terrando N

Journal: Anesthesiology

DOI: 10.1097/ALN.0000000000002103.

Year Published: 2018

BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and […]

Computerized Cognitive Testing for Use in Clinical Trials: A Comparison of the NIH Toolbox and Cogstate C3 Batteries.

Authors: Buckley RF, Burnham S, Dekhtyar M, Martin C, Papp KV, Rentz DM, Sparks KP, Sperling RA

Journal: The Journal of Prevention of Alzheimer's Disease

Volume & Issue: 4 & 1

Page No.: 3-11

DOI: 10.14283/jpad.2017.1.

Year Published: 2018

BACKGROUND As prevention trials for Alzheimer’s disease move into asymptomatic populations, identifying older individuals who manifest the earliest cognitive signs of Alzheimer’s disease is critical. Computerized cognitive testing has the potential to replace current gold standard paper and pencil measures and may be a more efficient means of assessing cognition. However, more empirical evidence about […]

Sleep and cognition in older adults: Does depression matter? An actigraphy and polysomnography study

Authors: Alix Mellor, Flavie Waters, Helen McGowan, Jennifer Maul, Katherine A. Sanders, Romola S. Bucks

Journal: Archives of Psychology

Volume & Issue: 2 & 1

Year Published: 2018

The impact of sleep on cognition is well recognised, although research in older adults is lacking, as are investigations into how depression might impact on this relationship. This study assessed the relationship between sleep (assessed with actigraphy and polysomnography) and cognitive performance in older adults (50–78 years) with (n = 10) and without (n = […]

A blood-based biomarker panel indicates IL-10 and IL-12/23p40 are jointly associated as predictors of β-amyloid load in an AD cohort.

Authors: Ames D, Bush AI, Doecke J, Gupta VB, Hone E, James I, Martins RN, Masters CL, O'Bryant S, Pedrini S, Rowe CC, Villemagne VL

Journal: Scientific Reports

Volume & Issue: 7 & 1

Page No.: 14057

DOI: 10.1038/s41598-017-14020-9

Year Published: 2017

Alzheimer’s Disease (AD) is the most common form of dementia, characterised by extracellular amyloid deposition as plaques and intracellular neurofibrillary tangles of tau protein. As no current clinical test can diagnose individuals at risk of developing AD, the aim of this project is to evaluate a blood-based biomarker panel to identify individuals who carry this […]

Vortioxetine for major depressive disorder, vasomotor, and cognitive symptoms associated with the menopausal transition.

Authors: Cheng LJ, Cohen LS, Davies A, Freeman MP, Hogan C, Moustafa D, Petrillo LF, Sosinsky AZ, Wang B

Journal: Annals of Clinical Psychiatry

Volume & Issue: 29 & 4

Page No.: 249-257

Year Published: 2017

BACKGROUND: In a preliminary trial, we assessed the efficacy of vortioxetine for major depressive disorder (MDD) during the menopausal transition. Secondary outcomes included hot flashes (HFs), anxiety, and cognitive complaints. METHODS: Perimenopausal and early postmenopausal women with MDD (N = 27) received 8 weeks of open-label, flexible-dose treatment with vortioxetine. The Montgomery-Åsberg Depression Rating Scale […]

Sensitivity of the Cogstate Test Battery for Detecting Prolonged Cognitive Alterations Stemming From Sport-Related Concussions.

Authors: Ellemberg D, Moore RD, Sicard V

Journal: Clinical Journal of Sport Medicine

DOI: 10.1097/JSM.0000000000000492

Year Published: 2017

OBJECTIVE: To determine if the Cogstate test battery contains the requisite sensitivity to detect prolonged cognitive alterations. METHODS: One hundred twenty collegiate athletes (71 with a history of concussion; 49 controls) completed the Cogstate test battery, to which we added a 2-back condition. In addition to the Cogstate clinical (transformed variables), we analyzed the raw […]

Insulin resistance is associated with reductions in specific cognitive domains and increases in CSF tau in cognitively normal adults.

Authors: Bruce D, Burnham S, Dore V, Fraser PE, Gaskin S, Laws SM, Li QX, Martins RN, Maruff P, Masters CL, Newsholme P, Porter T, Rainey-Smith S, Rowe CC, Salvado O, Srikanth V, Verdile G, Villemagne VL, Wijesekara N, Woodfield A

Journal: Scientific Reports

Volume & Issue: 7 & 1

Page No.: 9766

DOI: 10.1038/s41598-017-09577-4

Year Published: 2017

Growing evidence supports the hypothesis that type 2 diabetes (T2D) increases the risk of developing dementia. Experimental evidence from mouse models demonstrates that the induction of T2D/insulin resistance (IR) can promote the accumulation of Alzheimer’s disease (AD) pathological features. However, the association of T2D with pathological and clinical phenotypes in humans is unclear. Here we […]

No Seasonal Changes in Cognitive Functioning Among High School Football Athletes: Implementation of a Novel Electrophysiological Measure and Standard Clinical Measures.

Authors: Broglio SP, Eckner JT, Meehan S, Moore B, Rettmann A, Williams R

Journal: Clinical Journal of Sport Medicine

DOI: 10.1097/JSM.0000000000000420

Year Published: 2017

OBJECTIVE: To evaluate neuroelectric and cognitive function relative to a season of football participation. Cognitive and neuroelectric function declines are hypothesized to be present in football athletes. DESIGN: Observational. SETTING: Athletic fields and research laboratory. PATIENTS (OR PARTICIPANTS): Seventy-seven high school athletes (15.9 + 0.9 years, 178.6 + 7.2 cm, 74.4 + 14.7 kg, and […]

Lorazepam Challenge for Individuals at Varying Genetic Risk for Alzheimer Disease.

Authors: Caselli RJ, Harel B, Hentz JG, Locke DEC, Maruff P, Stonnington CM, Zhang N

Journal: Alzheimer Disease and Associated Disorders

DOI: 10.1097/WAD.0000000000000200

Year Published: 2017

INTRODUCTION: This study set out to clarify the differential acute cognitive impact of lorazepam based on varying genetic risk for Alzheimer disease. METHODS: Fifty-seven cognitively unimpaired individuals aged 51 to 88, genotyped according to apolipoprotein E (APOE) and translocase of outer mitochondrial membrane (40 homolog) poly-T lengths, completed cognitive testing before, 2.5 and 5 hours […]

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