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Access hundreds of peer-reviewed cognitive research papers published by leading neuroscientists using Cogstate technology.

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The relationship between peripheral hearing loss and higher order listening function on cognition in older Australians.

Authors: Dowell R, Nixon G, Sarant JZ, Tomlin D

Journal: International journal of audiology

DOI: 10.1080/14992027.2019.1641752

Year Published: 2019

Objective: Peripheral hearing, central auditory processing (CAP) and cognition are all important for comprehension of speech and deteriorate with increased age. This study aimed to examine the relation between hearing impairment and cognitive impairment by assessing both peripheral hearing impairment and CAP ability. Design: Cognition was measured using the CogState Brief Battery (CSBB). Peripheral hearing […]

The feasibility, reliability and concurrent validity of the MSReactor computerized cognitive screening tool in multiple sclerosis.

Authors: Butzkueven H, Darby D, Kalincik T, Merlo D, Van der Walt A

Journal: Therapeutic advances in neurological disorders

DOI: 10.1177/1756286419859183

Year Published: 2019

Background: Multiple sclerosis (MS) cognitive tests are resource intensive and limited by practice effects that prevent frequent retesting. Brief, reliable and valid monitoring tools are urgently needed to detect subtle, subclinical cognitive changes in people with MS. Cognitive monitoring over time could contribute to a new definition of disease progression, supplementing routine clinical monitoring. Methods: […]

Elements virtual rehabilitation improves motor, cognitive, and functional outcomes in adult stroke: evidence from a randomized controlled pilot study.

Authors: Duckworth J, Middleton S, Rogers JM, Steenbergen B, Wilson PH

Journal: Journal of neuroengineering and rehabilitation

DOI: 10.1186/s12984-019-0531-y

Year Published: 2019

BACKGROUND: Virtual reality technologies show potential as effective rehabilitation tools following neuro-trauma. In particular, the Elements system, involving customized surface computing and tangible interfaces, produces strong treatment effects for upper-limb and cognitive function following traumatic brain injury. The present study evaluated the efficacy of Elements as a virtual rehabilitation approach for stroke survivors. METHODS: Twenty-one […]

Protocol for a prospective cohort study of assessing postoperative cognitive changes after total hip and knee arthroplasty in the Greater Toronto area.

Authors: Au S, Avramescu S, Choi S, Orser BA

Journal: BMJ Open

DOI: 10.1136/bmjopen-2018-024259

Year Published: 2019

INTRODUCTION: Cognitive changes after anaesthesia and surgery, such as delirium and postoperative cognitive dysfunction (POCD), are common and lead to poor outcomes and increased healthcare costs. While several interventions for delirium exist, there are no effective treatment strategies for POCD. Understanding the risks and contributing factors may offer clinicians unique opportunities to better identify and […]

Klotho allele status is not associated with Aβ and APOE ε4-related cognitive decline in preclinical Alzheimer’s disease.

Authors: Ames D, Burnham SC, Groth D, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Milicic L, Porter T, Rainey-Smith S, Rowe CC, Salvado O, Savage G, Verdile G, Villemagne VL

Journal: Neurobiology of Aging

DOI: 10.1016/j.neurobiolaging.2018.12.014

Year Published: 2019

The longevity gene Klotho (KL), specifically the functional KL-VS variant, has previously been associated with cognition and rates of cognitive decline. This study aimed to determine whether KL-VS associations with cognition were observable in preclinical Alzheimer’s disease (AD). The study also aimed to determine whether there was a combined influence of KL-VS, neocortical amyloid-β (Aβ) […]

A Videogame-Based Digital Therapeutic to Improve Processing Speed in People with Multiple Sclerosis: A Feasibility Study.

Authors: Alailima T, Anguera J, Bove RM, Feinstein A, Garcha P, Gazzaley A, Langdon D, Morrissey J, Possin K, Rowles W, Rush G, Schembri A, Zhao C

Journal: Neurology & therapy

DOI: 10.1007/s40120-018-0121-0

Year Published: 2019

INTRODUCTION: Self-administered in-home digital therapeutics could expand access to cognitive rehabilitation for individuals with multiple sclerosis (MS), over half of whom experience cognitive impairment (CI). However, feasibility in an MS population must be clarified. This study was conducted to assess the feasibility of deploying a videogame-like digital treatment for CI in MS, including initial efficacy […]

Cognitive capacity similarly predicts insight into symptoms in first- and multiple-episode psychosis.

Authors: Brodeur MB, Joober R, Kline RB, Lepage M, Malla A, Sauvé G, Shah JL

Journal: Schizophrenia Research

DOI: 10.1016/j.schres.2018.11.013

Year Published: 2019

BACKGROUND: Lack of insight is a frequent characteristic of psychotic disorders, both in patients who recently experienced a first episode of psychosis (FEP) and those who experience recurrent multiple episodes (MEP). Insight is a multifaceted construct: its clinical form notably includes the unawareness of being ill, of symptoms, and of the need for treatment. Cognitive […]

Brief Computer-Based Information Processing Measures are Linked to White Matter Integrity in Pediatric-Onset Multiple Sclerosis.

Authors: Bartlett E, Charvet LE, DeLorenzo C, Feinberg C, Krupp LB, Schwarz C, Shaw M

Journal: Journal of neuroimaging : official journal of the American Society of Neuroimaging

DOI: 10.1111/jon.12566

Year Published: 2019

BACKGROUND AND PURPOSE: Pediatric-onset multiple sclerosis (POMS) is a demyelinating disorder with unique clinical challenges. A brief computer-administered cognitive screening battery measuring processing speed (Cogstate) and the Brief International Cognitive Assessment in MS (BICAMS) detect cognitive impairment in POMS. The neuroanatomic correlates of these deficits are incompletely understood. The purpose of this study is to […]

Exercise effects on cognitive functioning in young adults with first-episode psychosis: FitForLife.

Authors: Ekblom Ö, Firth J, Forsell Y, Hallgren M, Schembri A, Skott M

Journal: Psychological Medicine

DOI: 10.1017/S0033291718001022

Year Published: 2019

BACKGROUND: Exercise has mood-enhancing effects and can improve cognitive functioning, but the effects in first-episode psychosis (FEP) remain understudied. We examined the feasibility and cognitive effects of exercise in FEP. METHOD: Multi-center, open-label intervention study. Ninety-one outpatients with FEP (mean age = 30 years, 65% male) received usual care plus a 12-week supervised circuit-training program, […]

Monitoring cognitive change in multiple sclerosis using a computerized cognitive battery.

Authors: Butzkueven H, Darby D, De Meijer L, Gale J, Grobbee EJ, Haartsen J, Maruff P, Merlo D, Skibina O, Van der Walt A

Journal: Multiple sclerosis journal - experimental translational and clinical

DOI: 10.1177/2055217318815513

Year Published: 2018

Background: Cognitive monitoring that can detect short-term change in multiple sclerosis is challenging. Computerized cognitive batteries such as the CogState Brief Battery can rapidly assess commonly affected cognitive domains. Objectives: The purpose of this study was to establish the acceptability and sensitivity of the CogState Brief Battery in multiple sclerosis patients compared to controls. We […]

Selenium Status Is Not Associated with Cognitive Performance: A Cross-Sectional Study in 154 Older Australian Adults.

Authors: Cardoso BR, Daly RM, Formica M, Gianoudis J, Nowson CA, O'Connell S, Roberts BR, Szymlek-Gay EA

Journal: Nutrients

DOI: 10.3390/nu10121847

Year Published: 2018

Selenium was suggested to play a role in modulating cognitive performance and dementia risk. Thus, this study aimed to investigate the association between selenium status and cognitive performance, as well as inflammatory and neurotrophic markers in healthy older adults. This cross-sectional study included 154 older adults (≥60 years) from Victoria, Australia. Participants were assessed for […]

Necessity of technicians for computerized neuropsychological assessment devices in multiple sclerosis.

Authors: Alberts J, Benedict RH, Drake AS, Maruff P, Pol J, Rao SM, Schembri AJ, Schindler D, Weinstock-Guttman B, Wojcik CM, Yasin F

Journal: Multiple sclerosis : Clinical and Laboratory Research

DOI: 10.1177/1352458518813287

Year Published: 2018

OBJECTIVE: Determine the influence of technician supervision on computer-administered cognitive tests in multiple sclerosis (MS). METHODS: Eighty MS patients underwent assessment using the CogState Brief Battery (CSBB) and the Cleveland Clinic Cognitive Battery (C3B). Each was administered twice, once with a technician guiding assessment, and once with technician-absent. Twenty-eight healthy controls were also evaluated. RESULTS: […]

Association between cognitive ability and functional outcomes following traumatic brain injury- using a computer-based neurocognitive battery.

Authors: Cullen N, Zarshenas S

Journal: Brain Injury

DOI: 10.1080/02699052.2018.1517223

Year Published: 2018

OBJECTIVE: To investigate the contribution of the Cogstate Brief Battery (CBB TM) in the explanation of variation of functional outcomes. DESIGN: Secondary analysis of the practice-based evidence data set. SETTING: Inpatient rehabilitation setting. PARTICIPANTS: Patients (≥ 18 years of age) with traumatic brain injury who were consecutively admitted to the Toronto Rehabilitation Institute between 2008 and 2011 […]

Total Sleep Time Interacts With Age to Predict Cognitive Performance Among Adults.

Authors: Flenniken D, Insel PS, Mackin RS, Maruff P, Mohlenhoff BS, Neylan TC, Nosheny R, Richards A, Weiner MW

Journal: Journal of clinical sleep medicine

DOI: 10.5664/jcsm.7342

Year Published: 2018

STUDY OBJECTIVES: To investigate interactions between high and low amounts of sleep and other predictors of cognitive performance. METHODS: We used four cognitive tests to determine whether sleep time interacted with age, personal history of a memory problem, parental history of a memory problem, or personal concerns about memory and were associated with cognitive performance. […]

Estimates of age-related memory decline are inflated by unrecognized Alzheimer’s disease.

Authors: Ames D, Dang C, Harrington KD, Hassenstab J, Laws SM, Lim YY, Maruff P, Masters CL, Rainey-Smith S, Robertson J, Rowe CC, Salvado O, Schembri A, Sohrabi HR, Villemagne VL, Weinborn M

Journal: Neurobiology of Aging

DOI: 10.1016/j.neurobiolaging.2018.06.005

Year Published: 2018

Cognitive decline is considered an inevitable consequence of aging; however, estimates of cognitive aging may be influenced negatively by undetected preclinical Alzheimer’s disease (AD). This study aimed to determine the extent to which estimates of cognitive aging were biased by preclinical AD. Cognitively normal older adults (n = 494) with amyloid-β status determined from positron emission […]

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