A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M 1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer’s disease

Authors: Pradeep J Nathan, S Babli Millais, Alex Godwood, Odile Dewit, David M Cross, Janet Liptrot, Bharat Ruparelia, Stephen Paul Jones, Geor Bakker, Paul T Maruff, Gregory A Light, Alastair J H Brown, Malcolm Peter Weir, Miles Congreve, Tim Tasker

Journal: Alzheimer's & Dementia

Year Published: 2022

Introduction: This study examined the safety and pharmacodynamic effects of selective muscarinic M1 receptor orthosteric agonist HTL0018318 in 60 patients with mild-to-moderate Alzheimer’s disease (AD) on background donepezil 10 mg/day. Methods: A randomized, double-blind, placebo-controlled 4-week […]

Severe childhood trauma and emotion recognition in males and females with first-episode psychosis

Authors: Danielle Penney, Marita Pruessner, Ashok K Malla, Ridha Joober, Martin Lepage

Journal: Early Intervention in Psychiatry

Year Published: 2022

Aim: Childhood trauma increases social functioning deficits in first-episode psychosis (FEP) and is negatively associated with higher-order social cognitive processes such as emotion recognition (ER). We investigated the relationship between childhood trauma severity and ER capacity, […]

Neurocognitive effects of repeated ketamine infusions in comorbid posttraumatic stress disorder and major depressive disorder

Authors: C Sophia Albott, Kelvin O Lim, Christopher Erbes, Paul Thuras, Joseph Wels, Susanna J Tye, Paulo R Shiroma

Journal: Journal of Affective Disorders

Year Published: 2022

Background: The glutamate N-methyl-d-aspartate (NMDA) receptor antagonist ketamine rapidly ameliorates posttraumatic stress disorder (PTSD) and depression symptoms in individuals with comorbid PTSD and major depressive disorder (MDD). However, concerns over ketamine’s potential neurocognitive side effects have […]

Natural Pattern of Cognitive Aging

Authors: Jan S Novotný, Juan P Gonzalez-Rivas, Maria Vassilaki, Janina Krell-Roesch, Yonas E Geda, Gorazd B Stokin

Journal: Journal of Alzheimer's Disease

Year Published: 2022

Background: Considering the world’s rapidly increasing life expectancy, with people working and maintaining active lifestyles longer than ever before, addressing the effects of aging on cognition is of utmost importance. A greater understanding of cognitive aging […]

Effects of a 6-Month Multifaceted Diet and Exercise Intervention on Cognition in Older Adults at Risk of Cognitive Decline: The PONDER Double-Blind, Placebo-Controlled Randomized Trial

Authors: Helen Macpherson, Sarah Brownell, Elizabeth Harris, Rachel L Duckham, Stella O'Connell, Barbara J Meyer, Sam Mirzaee, Robin M Daly

Journal: Journal of Alzheimer's Disease

Year Published: 2022

Background: Multidomain interventions which incorporate exercise and dietary supplementation to target both cognitive and physical health domains may be an important approach to delay cognitive decline. Objective: The Protein Omega-3 aNd vitamin D Exercise Research (PONDER) […]

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