Neurocognitive effects of acute choline supplementation in low, medium and high performer healthy volunteers

Authors: Verner Knott, Sara de la Salle, Joelle Choueiry, Danielle Impey, Dylan Smith, Meaghan Smith, Elise Beaudry, Salman Saghir, Vadim Ilivitsky, Alain Labelle

Journal: Pharmacology Biochemistry and Behavior

Year Published: 2015

Novel pharmacological treatments targeting alpha 7 nicotinic acetylcholine receptor (α7 nAChR) hypofunction in schizophrenia have shown mixed success in ameliorating cognitive impairments associated with this disorder. Choline, a selective agonist at α7 receptors is increased with […]

CDP-choline: Effects of the procholine supplement on sensory gating and executive function in healthy volunteers stratified for low, medium and high P50 suppression

Authors: Verner Knott, Dylan Smith, Sara de la Salle, Danielle Impey, Joelle Choueiry, Elise Beaudry, Meaghan Smith, Salman Saghir, Vadim Ilivitsky, Alain Labelle

Journal: Journal of Psychopharmacology

Year Published: 2014

Diminished auditory sensory gating and associated neurocognitive deficits in schizophrenia have been linked to altered expression and function of the alpha-7 nicotinic acetycholinergic receptor (α7 nAChR), the targeting of which may have treatment potential. Choline is […]

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