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18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery.

Authors: Berger M, Bisanar T, Borges-Neto S, Doraiswamy PM, James OG, Klinger RY, Li YJ, Mathew JP, Newman MF, Qi W, Terrando N

Journal: Anesthesiology

DOI: 10.1097/ALN.0000000000002103.

Year Published: 2018

BACKGROUND: Amyloid deposition is a potential contributor to postoperative cognitive dysfunction. The authors hypothesized that 6-week global cortical amyloid burden, determined by F-florbetapir positron emission tomography, would be greater in those patients manifesting cognitive dysfunction at 6 weeks postoperatively. METHODS: Amyloid deposition was evaluated in cardiac surgical patients at 6 weeks (n = 40) and […]

Plasma amyloid beta42 and amyloid beta40 levels are associated with early cognitive dysfunction after cardiac surgery.

Authors: Cherny RA, Cowie T, Evered LA, Laughton KM, Li QX, Maruff P, Masters CL, Scott DA, Silbert BS, Volitakis I

Journal: The Annals of Thoracic Surgery

Volume & Issue: 88 & 5

Page No.: 1426-32

DOI: 10.1016/j.athoracsur.2009.07.003

Year Published: 2009

BACKGROUND: Decreased cognitive function associated with coronary artery bypass graft surgery is common. These deficits may be similar to the cognitive dysfunction seen in the spectrum of mild cognitive impairment to Alzheimer’s disease, which are believed to result from the accumulation of amyloid beta (Abeta) peptide in the brain. We measured cognition both before and […]