brain-derived neurotrophic factor

APOE and BDNF polymorphisms moderate amyloid β-related cognitive decline in preclinical Alzheimer’s disease.

Authors: Ames D, Ellis KA, Harrington K, Laws SM, Lim YY, Martins RN, Maruff P, Masters CL, Pietrzak RH, Rembach A, Rowe CC, Snyder PJ, Villemagne VL

Journal: Molecular Psychiatry

Accumulation of β-amyloid (Aβ) in the brain is associated with memory decline in healthy individuals as a prelude to Alzheimer’s disease (AD). Genetic factors may moderate this decline. We examined the role of apolipoprotein E (ɛ4 […]

Influence of BDNF Val66Met on the relationship between physical activity and brain volume.

Authors: Ames D, Bartrés-Faz D, Bourgeat P, Brown BM, Burnham S, Bush A, Ellis KA, Laws SM, Macaulay SL, Martins RN, Maruff P, Masters CL, Peiffer JJ, Rainey-Smith SR, Rembach A, Rowe CC, Taddei K, Villemagne VL

Journal: Neurology

OBJECTIVE: To investigate the association between habitual physical activity levels and brain temporal lobe volumes, and the interaction with the brain-derived neurotrophic factor (BDNF) Val66Met polymorphism. METHODS: This study is a cross-sectional analysis of 114 cognitively […]

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